A5072568326- Venomous Animal Envenomation and Studies
- Neonatal Respiratory Health Research
- Marine Invertebrate Physiology and Ecology
- Congenital Diaphragmatic Hernia Studies
- Respiratory Support and Mechanisms
- Marine Toxins and Detection Methods
- Ion channel regulation and function
- Healthcare and Venom Research
- Neonatal and fetal brain pathology
- Infant Development and Preterm Care
- Pregnancy and preeclampsia studies
- Insect and Pesticide Research
- Neuroscience of respiration and sleep
- Neurogenetic and Muscular Disorders Research
- Cell death mechanisms and regulation
- Bacterial Infections and Vaccines
- Corporate Social Responsibility Reporting
- Vector-borne infectious diseases
- Tracheal and airway disorders
- Birth, Development, and Health
- Genomics and Rare Diseases
- Metabolism and Genetic Disorders
- Respiratory viral infections research
- Neonatal Health and Biochemistry
- COVID-19 Clinical Research Studies
Osaka Women's and Children's Hospital
2018-2025
Mitsubishi Group (Japan)
2020
Osaka International Cancer Institute
2010-2017
Okinawa Prefectural Institute of Health and Environment
1988-2008
National Defense Medical College
2004-2008
Meiji Pharmaceutical University
2008
Osaka University
1991-1996
In newborn screening (NBS), it is important to consider the availability of multiplex assays or other tests that can be integrated into existing systems when attempting implement NBS for new target diseases. Recent developments in innovative testing technology have made possible simultaneously screen severe primary immunodeficiency (PID) and spinal muscular atrophy (SMA) using quantitative real-time polymerase chain reaction (qPCR) assays. We describe our experience optional PID SMA Osaka,...
<title>Abstract</title> Objective A reliable method for verifying the position of a nasogastric tube (NGT) or an orogastric (OGT) does not exist. This study determined whether using light-emitting diode source and fiber (LED-SF) can accurately confirm tip NGT/OGT in neonates. Study Design prospective multicenter was conducted at five tertiary NICUs. inserted LED-SF. Cross-tabulation test Bland-Altman analysis were performed to evaluate correctly inserted. Results total 101 neonates with...
ObjectiveTo delineate the diagnostic efficacy of medical exome, whole and genome sequencing according to primary symptoms, contribution small copy number variations, impact molecular diagnosis on clinical management.Study designThis was a prospective study 17 tertiary care centers in Japan, conducted between April 2019 March 2021. Critically ill neonates infants less than 6 months age were recruited neonatal intensive units outpatient clinics. The patients underwent or as first tier testing....
The venomous sea anemone Phyllodiscus semoni causes cases of severe stinging. We isolated toxin 20A (PsTX-20A), a hemolytic and lethal polypeptide (20 kDa), from the nematocyst venom this species for first time. Furthermore, we sequenced cDNA encoding PsTX-20A. deduced amino acid sequence PsTX-20A showed that was new member actinoporin family, which consists several cytolytic polypeptides originating anemones. toxicity to shrimp Palaemon paucidens when administered via intraperitoneal...
Journal Article Structural Divergence of Cysteine-Rich Secretory Proteins in Snake Venoms Get access Yukiko Matsunaga, Matsunaga 1Department Biochemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588; and 2Okinawa Prefectural Institute Health Environment, 2003 Ozato, Nanjo, Okinawa 901-1202, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Yasuo Yamazaki, Yamazaki Fumiko Hyodo, Hyodo Yusuke Sugiyama, Sugiyama Masatoshi Nozaki,...
Mouse cytokeratin EndoA is an intermediate filament subunit of the type II class which initiates expression in trophectoderm cells blastocyst during embryogenesis. To identify regulatory elements endo A gene, we constructed a series CAT vectors and transfected them into PYS-2 cells. We found enhancer element locating 1 kb downstream from gene acts on both SV40 promoters. This consists six direct repeated sequences with homology to PEA3 motif polyoma virus alpha core. In undifferentiated F9...
Abstract Infantile liver failure syndrome type 1 (ILFS1) is a recently recognized autosomal recessive disorder caused by deleterious mutations in the leucyl‐tRNA synthetase gene ( LARS1 ). The enzyme responsible for incorporation of amino acid leucine during protein polypeptide synthesis. Individuals with typically show from infancy to early childhood periods illness or other physiological stress. While 25 patients 15 families ILFS1 have been reported literature, histological reports autopsy...