A5001744143- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- Epilepsy research and treatment
- Genetics and Neurodevelopmental Disorders
- Metabolism and Genetic Disorders
- Radiomics and Machine Learning in Medical Imaging
- Diet and metabolism studies
- Cancer Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Cancer and Skin Lesions
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Breast Implant and Reconstruction
- HER2/EGFR in Cancer Research
- Autoimmune Neurological Disorders and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Infectious Encephalopathies and Encephalitis
- Hedgehog Signaling Pathway Studies
- Medical Imaging Techniques and Applications
- Peripheral Neuropathies and Disorders
- Neurological disorders and treatments
- Lysosomal Storage Disorders Research
- Glycogen Storage Diseases and Myoclonus
- Parkinson's Disease and Spinal Disorders
Osaka Women's and Children's Hospital
2018-2025
Nippon Medical School
2012-2025
Nippon Medical School Hospital
2015-2021
European Neuroendocrine Tumor Society
2019
Hospices Civils de Lyon
2018
Centre de Recherche en Neurosciences de Lyon
2018
Hôpital Femme Mère Enfant
2018
Osaka International Cancer Institute
1999-2016
Chiba Cancer Center
2014
Kyoto University Hospital
2007
V-type proton (H+) ATPase (v-ATPase) is a multi-subunit pump that regulates pH homeostasis in all eukaryotic cells; neurons, v-ATPase plays additional and unique roles synapse function. Through whole exome sequencing, we identified de novo heterozygous mutations (p.Pro27Arg, p.Asp100Tyr, p.Asp349Asn, p.Asp371Gly) ATP6V1A, encoding the A subunit of v-ATPase, four patients with developmental encephalopathy epilepsy. Early manifestations, observed patients, were delay febrile seizures, evolving...
Abstract Background Sentinel lymph node biopsy is a standard staging procedure for early axillary node‐negative breast cancer. As an alternative to the currently used radioactive tracers sentinel (SLN) detection during surgical procedure, number of studies have shown promising results using superparamagnetic iron oxide (SPIO) nanoparticles. Here, we developed new handheld, cordless, and lightweight magnetic probe SPIO detection. Methods Resovist (SPIO nanoparticles) were detected by newly...
Background An advantage of PET/CT has been demonstrated for diagnosis several tumor entities. In patients with breast cancer, early and accurate restaging recurrence after surgery is important selection the most appropriate therapeutic strategy. Purpose To evaluate accuracy integrated positron emission tomography computed (PET/CT) using 18F-fluorodeoxyglucose (FDG), follow-up suspected recurrent cancer. Material Methods Forty-seven cancer underwent PET/CT. The PET images were interpreted...
Use of radiocolloids for sentinel lymph node (SLN) detection in breast cancer (BC) offers the advantage utilizing single-photon emission computed tomography/computed tomography (SPECT/CT). This study explored whether SPECT/CT findings can predict pathological axillary (ALN) metastasis. A consecutive series patients with invasive BC (clinical stage, T1-3, N0, and M0) who underwent SLN biopsy (SLNB) using between January 2011 December 2016 were included. detection, location, number on...
Although advances in neoadjuvant chemotherapy (NAC) are improving the rate of pathological complete response (pCR) and outcomes for triple-negative breast cancer (TNBC) patients, prognosis remains poor. Insulin-like growth factor II mRNA-binding protein 3 (IMP3) expression was recently reported to be associated with resistance poor TNBC. We evaluated IMP3 40 female TNBC patients assess its association NAC sensitivity outcome. Among cohort, 11 (27.5%) had IMP3-positive TNBC, which a higher...
Summary: Purpose: In infants, benign convulsions can be triggered by febrile illness or mild diarrhea such as Rotavirus gastroenteritis. The triggering mechanism of these is still unknown. spite several reports concerning clinical features, the ictal EEG recordings were rarely analyzed a video‐EEG monitoring system. To reveal clue for convulsions, we correlation manifestations and discharges during events compared with previous reports. Methods: cluster three afebrile associated...
To evaluate the gamma-band activity related to somatosensory processing, we recorded neuromagnetic signals from seven healthy subjects. The source power changes evoked by electrical stimulation of median nerve were estimated with synthetic aperture magnetometry (SAM). Source in low gamma band (40 Hz) decreased contralateral primary cortex (SI) for a few hundred milliseconds (i.e. middle and long latency) then increased inversely. high (70-90 simultaneously both SI contra/ipsilateral...
PIK3CA is associated with tumor progression, and the prevalence of mutation high in breast cancer. Liquid biopsy offers convenient, noninvasive, real-time insight into genetic alteration. In this study, we used liquid to detect mutations patients cancer.We recruited histologically confirmed cancer distant metastases between April 2020 September 2020. Circulating DNA was extracted from plasma (ctDNA) exosomes (exoDNA). (exons 9 20) were analyzed by droplet digital PCR.Of 52 recruited, 16 had...
Objective Pleomorphic lobular carcinoma ( PLC ) is a subtype of breast cancer with unique morphological features, but it remains controversial whether should be considered an independent disease entity. The aim this study was to illustrate cytopathological characteristics in comparison other variants. Methods We investigated clinicopathological features n = 11) compared those variants invasive (ILC, non‐ 32). Histological the group consisted classic 25), solid 2), alveolar 1) and...
We have analyzed proteins produced in Various human gastric carcinoma cell lines and normal mucosa. The production of HSP90 increased eight lines. Gelsolin content was down-regulated seven Furthermore, the GST-pi a poorly differentiated adenocarcinoma line two scirrhous These results suggest that down-regulation gelsolin play an important role carcinogenesis, abundant is related to unique behavior some carcinomas.