A5056651603- Tumors and Oncological Cases
- Gastrointestinal Tumor Research and Treatment
- Gastric Cancer Management and Outcomes
- Intracranial Aneurysms: Treatment and Complications
- Testicular diseases and treatments
- Teratomas and Epidermoid Cysts
- Assisted Reproductive Technology and Twin Pregnancy
- Neuroendocrine Tumor Research Advances
- Metastasis and carcinoma case studies
- Lung Cancer Research Studies
- Fungal Infections and Studies
- Pancreatic and Hepatic Oncology Research
- Cardiac Arrhythmias and Treatments
- Oral health in cancer treatment
- Genetic and Kidney Cyst Diseases
- Autoimmune Bullous Skin Diseases
- HER2/EGFR in Cancer Research
- Colorectal Cancer Treatments and Studies
- Breast Implant and Reconstruction
- Actinomycetales infections and treatment
- Fluid Dynamics and Mixing
- Genomics and Rare Diseases
- Toxoplasma gondii Research Studies
- Parasitic Infections and Diagnostics
- RNA regulation and disease
Kagawa Prefectural Central Hospital
2021-2024
Hamamatsu University School of Medicine
2024
Osaka Women's and Children's Hospital
2019-2024
Clinical Research Management
2020
National Institute of Infectious Diseases
2019
Kobe City Medical Center General Hospital
2014-2018
Tokyo University of Science
2015-2018
Shizuoka University
2008
Gifu University
1989
We assessed the effects of ATRA and retinol on melanogenesis in murine B16 melanoma cells. In present study, inhibited melanin synthesis cells stimulated by alpha-melanocyte stimulating hormone (alpha-MSH) or 3-isobutyl-1-methylxanthine (IBMX). To elucidate target points melanogenesis, we performed western blotting for melanogenic proteins, such as tyrosinase, tyrosinase-related protein (TRP)-1, TRP-2. expression tyrosinase TRP-1, a dose-dependent manner. Neither nor TRP-2 expression. There...
BackgroundThe prognosis of locally advanced gastric cancer, such as clinical T4 disease, bulky nodal involvement, type 4 and large 3 remains unsatisfactory, even with D2 gastrectomy followed by adjuvant chemotherapy. One promising approach is neoadjuvant Combination chemotherapy S-1 oxaliplatin (SOX) recognised a potentially regimen for cancer. However, the use consisting SOX cancer has not been reported. The aim this study was to determine maximum tolerated dose (MTD) recommended...
Abstract Infantile liver failure syndrome type 1 (ILFS1) is a recently recognized autosomal recessive disorder caused by deleterious mutations in the leucyl‐tRNA synthetase gene ( LARS1 ). The enzyme responsible for incorporation of amino acid leucine during protein polypeptide synthesis. Individuals with typically show from infancy to early childhood periods illness or other physiological stress. While 25 patients 15 families ILFS1 have been reported literature, histological reports autopsy...
Lymphoproliferative disorders may occur in patients with rheumatoid arthritis (RA) who are treated methotrexate. However, follicular thymic hyperplasia (FTH) associated RA (FTH-RA) is generally not considered a lymphoproliferative disorder. To investigate the pathogenesis of FTH-RA, we examined 12 cases FTH involving enlargement, four and eight myasthenia gravis (MG). Increased numbers larger germinal center (GC) size were observed FTH-RA group. The percentage distorted GCs was 13.3% group...
Aim: To determine the recommended dose of neoadjuvant chemotherapy combined capecitabine and oxalipatin (G-XELOX) for locally advanced gastric cancer. Patients Methods: received two cycles with oxaliplatin on day 1 (2,000 mg/m<sup>2</sup>/day, b.i.d.) days 1-14, repeated every 3 weeks. They then underwent gastrectomy curative D2/3 lymph-node dissection followed by adjuvant therapy S-1 year. De-escalation was planned (starting at level 1, 130 mg/m<sup>2</sup>). Results: Six patients were...
Mizuno, Yasushi MD; Imoto, Hiroharu Takahashi, Natsuko Ichikawa, Chihiro Nishioka, Hiroaki MD, PhD Author Information
A short-coupled variant of torsade de pointes (ScTdP) is rare and resistant to medical treatment. There has not been a reported catheter ablation (CA) premature ventricular contraction (PVC) triggering ScTdP in an infant.A neonate was referred our hospital on the day birth for Wolff-Parkinson-White syndrome, repeated episodes supraventricular tachycardia, left non-compaction. She underwent CA accessory pathway at 72 days age. On 5th after ablation, she had recurrent TdP various...
The pathogenesis of gonadotropin-independent precocious puberty (PP) includes both congenital and acquired forms, the latter which may be associated with neoplasms, such as sex-steroid hormone-producing tumors. Beta-human chorionic gonadotropin (β-hCG)-producing tumors also cause PP by stimulating production testosterone in Leydig cells. Germ cell hepatoblastoma produce β-hCG; however, there is limited evidence to show that caused other β-hCG-producing We herein report first case...
An atrioventricular node (AVN) ablation and permanent pacing have been previously reported as effective treatments for patients with atrial tachyarrhythmias. However single-ventricle requiring chronic ventricular are at a higher risk of developing dysfunction valve regurgitation. We report case successful AVN in 3-month-old infant hypoplastic left heart syndrome ectopic tachycardia (EAT).
We report the case of a 76-year-old man who presented with pain in right upper abdomen. Laboratory and radiological examinations revealed cholangitis, cholelithiasis, gallbladder tumor adhering to transverse colon. After receiving conservative therapy for patient underwent surgery disease. On surgery, cholecysto-colonic fistula communicating colon was revealed, combined resection partial performed. The resected sample an intracholecystic papillary neoplasm focal invasive component,...
Abstract Background The pathological evaluation of cancellous bone at resection margins mandibular osteoradionecrosis (ORN) has not been well elucidated. Here, we developed a unique classification system for evaluating the degree marrow fibrosis, one most common features, in patients with ORN, based on which investigated its relationship treatment outcome. Methods This study included 15 who underwent mandibulectomy and free fibula osteocutaneous flap reconstruction. extent was determined,...
Hemodynamic analysis of cerebral aneurysms has been widely carried out to clarify the mechanisms their growth and rupture. In several cases, patient-specific aneurysm models made transparent polymers have used. Even though periodic changes in due pulsation blood flow could be important, deformation model geometry its effect on hemodynamic evaluation not fully investigated. addition, fabrication accuracy evaluated even it may affect parameters analyzed. this study, a silicone was...
症例は67歳，女性．黄疸を主訴に近医受診，磁気共鳴胆道膵管造影にて下部胆管閉塞を認め当院消化器内科に紹介．CTで下部胆管に20mm大の腫瘍を認め，胆管は閉塞していた．膵頭部背側に腫大したリンパ節を認めた．内視鏡的逆行性胆道膵管造影では胆管内に突出する内部不均一，境界明瞭な腫瘤を認めた．ポジトロンCTでは下部胆管の腫瘤にSUVmax=5.6の集積を認め，CTで指摘されたリンパ節も軽度集積を認めた．下部胆管癌の診断で亜全胃温存膵頭十二指腸切除術を施行したところ，膵頭部に白色腫瘤を認め，その上流の胆管は著明に拡張していた．またリンパ節#13に転移を認めた．組織像では腫瘍細胞は胞巣状～シート状に配列し，周囲組織に浸潤していた．免疫染色に加え，MIB-1 indexおよび核分裂像から，2010年WHO分類においてNET G2に相当する胆管原発の神経内分泌腫瘍と診断した．
Hemodynamic researches about cerebral aneurysm have been widely performed to estimate or predict the danger of growth and rupture in patients. In this study, we developed an automated vitro measurement system flow fields models based on scanning stereoscopic particle image velocimetry. The method vessel wall estimation by using PIV data, which is quite essential carry out a hemodynamic evaluation, was investigated; extrapolation velocity-gradient superposition were tested. As result,...