A5028248498- Diabetes Treatment and Management
- Diabetes Management and Research
- Bone health and treatments
- Metabolism, Diabetes, and Cancer
- Bone Metabolism and Diseases
- Pancreatic function and diabetes
- Parathyroid Disorders and Treatments
- Diabetes and associated disorders
- Hematopoietic Stem Cell Transplantation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Disease Prevention
- Inflammatory mediators and NSAID effects
- Chronic Myeloid Leukemia Treatments
- Bone health and osteoporosis research
- Pharmacology and Obesity Treatment
- Cardiovascular Function and Risk Factors
- Pituitary Gland Disorders and Treatments
- Cell Adhesion Molecules Research
- Acute Myeloid Leukemia Research
- Blood Pressure and Hypertension Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Medical Imaging and Pathology Studies
- Vitamin D Research Studies
- Neuroendocrine Tumor Research Advances
University of Occupational and Environmental Health Japan
2016-2025
Jichi Medical University
2022-2025
Jichi Medical University Saitama Medical Center
2022-2025
Palmetto Hematology Oncology
2024
University of Oxford
2023
Kyushu Rosai Hospital
2023
Osaka University
2023
The Institute of Statistical Mathematics
2023
The University of Tokyo
2023
RIKEN Center for Integrative Medical Sciences
2023
Basic fibroblast growth factor (FGF-2), an important modulator of cartilage and bone differentiation, is expressed regulated in osteoblastic cells. To investigate the role FGF-2 bone, we examined mice with a disruption Fgf2 gene. Measurement trabecular architecture femoral metaphysis Fgf2+/+ Fgf2–/– adult by micro-CT revealed that platelike structures were markedly reduced many connecting rods lost mice. Dynamic histomorphometry confirmed significant decrease volume, mineral apposition,...
Abstract Background Fluctuations in blood glucose level cause endothelial dysfunction and play a critical role onset and/or progression of atherosclerosis. We hypothesized that fluctuation levels correlate with vascular this relationship can be assessed using common bedside medical devices. Methods were measured over 24 hours by continuous monitoring (CGM) on admission day 2 57 patients type diabetes mellitus. The reactive hyperemia index (RHI), an function, was peripheral arterial tonometry...
We examined the effect on osteoclast formation of disrupting prostaglandin G/H synthase genes PGHS-1 and-2. Prostaglandin E2 (PGE2) production was significantly reduced in marrow cultures from mice lacking PGHS-2 (PGHS-2–/–) compared with wild-type (PGHS-2+/+) cultures. Osteoclast formation, whether stimulated by 1,25-dihydroxyvitamin D3 (1,25-D) or parathyroid hormone (PTH), 60–70% PGHS-2–/– relative to cultures, an that could be reversed providing exogenous PGE2. Cultures heterozygous...
<i>Background:</i> Mönckeberg’s calcification in diabetes, known as medial artery calcification, is an independent predictor of cardiovascular mortality. However, the mechanism underlying this phenomenon remains to be elucidated. We demonstrate that advanced glycation end products (AGEs) induce vascular smooth muscle cells through receptor for AGE (RAGE)/p38 mitogen-activated protein kinase (MAPK) signaling pathway. <i>Methods:</i> detected by von Kossa staining....
Abstract Objective Mesenchymal stem cells (MSCs) are considered to be a novel tool for the treatment of rheumatoid arthritis (RA) because their multipotency differentiate into osteoblasts and chondrocytes, immunosuppressive effects, availability. The aim this study was assess mechanisms human MSC differentiation under inflammatory conditions. Methods Human MSCs were cultured in commercialized osteogenic induction medium with cytokines up 10 days. Osteoblast detected by alkaline phosphatase...
Abstract Background Few prospective studies have compared the cardiovascular benefits of sodium-glucose cotransporter-2 (SGLT2) inhibitors and dipeptidyl peptidase 4 (DPP-4) inhibitors. We aimed to clarify efficacy dapagliflozin versus sitagliptin for modulating cardiometabolic risk factors including high glycated hemoglobin (HbA1c) levels, hypoglycemia, body weight. Methods This prospective, randomized, open-label, blinded-endpoint, parallel-group trial enrolled 340 Japanese patients with...
Abstract Objective To assess whether eldecalcitol, an active vitamin D analogue 2 , can reduce the development of type diabetes among adults with impaired glucose tolerance. Design Double blinded, multicentre, randomised, placebo controlled trial. Setting Three hospitals in Japan, between June 2013 and August 2019. Participants People aged 30 years older who had tolerance defined by using a 75 g oral test glycated haemoglobin level. Interventions were randomised to receive (eldecalcitol 0.75...
The 2004 edition of guidelines on the management and treatment glucocorticoid-induced osteoporosis Japanese Society for Bone Mineral Research had been developed based results a longitudinal study by subcommittee members an analysis patients collected Subcommittee to Study Diagnostic Criteria Corticosteroid-Induced Osteoporosis, together with evidence obtained overseas in Japan at 2004. This guideline is now going be revised. In this review, I want introduce history American College...
BackgroundObservational studies show inverse associations between serum 25-hydroxyvitamin D concentrations and sarcopenia incidence; however, it remains unclear whether treatment with vitamin prevents its development. We aimed to assess active (eldecalcitol [0·75 μg per day]) can reduce the development of among adults prediabetes.MethodsThis randomised, double-blind, placebo-controlled, multicenter trial as an ancillary study was conducted at 32 clinics hospital sites in Japan. Participants...
Abstract Prostaglandin E2 (PGE2) stimulates the formation of osteoclast-like tartrate-resistant acid phosphatase-positive multinucleated cells (TRAP + MNC) in vitro. This effect likely results from stimulation adenylyl cyclase, which is mediated by two PGE2 receptors, designated EP2 and EP4. We used mice receptor had been disrupted to test its role TRAP MNC. heterozygous (±) a C57BL/6 x 129/SvEv background were bred produce homozygous null (EP2 −/−) wild-type +/+) mice. PGE2, PTH, or 1,25...
MINT‐7301204, MINT‐7301186: RhoA (uniprotkb:P61586) physically interacts (MI:0915) with RAGE (uniprotkb:Q15109) by anti bait coimmunoprecipitation (MI:0006)
Abstract Introduction The aim of the present study was to determine effect sitagliptin on microalbuminuria in patients with type 2 diabetes mellitus. Materials and Methods A total 85 mellitus (age >20 years, <80 hemoglobin 1c [ H bA1c] <8.4%) were randomized taking 50 mg or other oral glucose‐lowering agents. following parameters evaluated at 0, 3 6 months after treatment: bodyweight, blood pressure, b 1c, fasting plasma glucose, insulin, low‐density lipoprotein cholesterol,...
Mesenchymal stem cells (MSCs) have been proposed to be a useful tool for treatment of rheumatoid arthritis (RA), not only because their multipotency but also immunosuppressive effect on lymphocytes, dendritic cells, and other proinflammatory cells. Since bone destruction caused by activated osteoclasts occurs in RA, we undertook the present study investigate MSCs osteoclast function differentiation order evaluate potential use RA therapy.Human peripheral blood mononuclear were cultured under...
Abstract Background Previous studies have suggested that high mean glucose levels and glycemic abnormalities such as fluctuation hypoglycemia accelerate the progression of atherosclerosis in patients with type 2 diabetes. Although continuous monitoring (CGM) could evaluate has been rapidly adopted, associations between CGM-derived metrics arterial stiffness are not entirely clear. Methods This exploratory cross-sectional study used baseline data from an ongoing prospective, multicenter,...
Abstract The two major processes of bone metabolism—bone formation and resorption—are regulated by cellular interactions. Osteoblasts osteoclasts play a significant role in metabolism, which is known to be local soluble factors systemic hormones. Although heterogeneous tissue comprised osteogenic hematopoietic cells, adhesion osteoblasts its regulation remains understood. We first demonstrate that communicate with opposing cells milieu involved the osteoblast activation: (a) purified human...
The mechanisms of ectopic calcification in inflammatory diseases are poorly understood. We investigated the effects cytokines on human adipose tissue-derived mesenchymal stem cells (hADSCs).The were evaluated using hADSCs cultured osteoblast induction medium. mRNA expression was measured by real-time PCR and protein levels western blotting. Cell mineralization Alizarin Red S staining.In hADSCs, administration IL-6/soluble IL-6 receptor (sIL-6R), TNF or IL-1β accelerated through enhanced an...
The rate of recurrence subacute thyroiditis (SAT) during prednisolone (PSL) therapy is approximately 10 to 20%. However, there little or no information on the time period relapse following administration a tapered dose PSL and factors associated with such relapse. aim this study was determine correlation between SAT tapering regimen used in treatment SAT. This medical record-based retrospective involved 26 patients (3 men, 23 women) who received for primary endpoint association number days...
This study aimed to investigate the preventive effects of tofogliflozin, a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor, on atherosclerosis progression in type diabetes (T2DM) patients without apparent cardiovascular disease (CVD) by monitoring carotid intima-media thickness (IMT).
Introduction Preventing the development and progression of diabetic microvascular complications through optimal blood glucose control remains an important challenge. Whether metrics based on continuous monitoring are useful for management is not entirely clear. Research design methods This exploratory analysis ongoing prospective, multicenter, 5-year follow-up observational study. Study participants included 999 outpatients with type 2 diabetes who underwent at baseline. Associations between...