A5014449911- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- Advanced Breast Cancer Therapies
- Cancer Immunotherapy and Biomarkers
- HER2/EGFR in Cancer Research
- Renal cell carcinoma treatment
- Gastric Cancer Management and Outcomes
- Renal Transplantation Outcomes and Treatments
- Multiple and Secondary Primary Cancers
- Monoclonal and Polyclonal Antibodies Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects and Toxicity Studies
- Lung Cancer Treatments and Mutations
- Bladder and Urothelial Cancer Treatments
- Analytical Methods in Pharmaceuticals
- Pharmaceutical studies and practices
- Parathyroid Disorders and Treatments
- Gastrointestinal Tumor Research and Treatment
- Transplantation: Methods and Outcomes
- Pancreatic and Hepatic Oncology Research
- Breast Cancer Treatment Studies
- Testicular diseases and treatments
- Epilepsy research and treatment
- Cardiac Valve Diseases and Treatments
Kindai University
2015-2024
Tenri Hospital
2024
Kansai Electric Power Hospital
2020-2023
Kyoto University
2017-2023
Kyoto University of Education
2023
Kobe City Medical Center General Hospital
2013-2022
Kyoto University Hospital
2017-2021
Toyonaka Municipal Hospital
2010-2015
Yao Tokushukai General Hospital
2015
National Cerebral and Cardiovascular Center
2005-2009
Abstract Chemotherapy-induced peripheral neuropathy (CIPN) is a severe dose-limiting side effect of taxanes such as paclitaxel and docetaxel. Despite the high medical needs, insufficient understanding complex mechanism underlying CIPN pathogenesis precludes any endorsed causal therapy to prevent or relieve CIPN. In this study, we report that elevation plasma galectin-3 level pathologic change common both patients with taxane-treated breast cancer mouse model taxane-related Following multiple...
We report a 39-year-old man with intravascular large B-cell lymphoma (IVLBCL) who had been treated as case pulmonary arterial hypertension (PAH) for one year. After he became worse, diffuse 18F-fluorodeoxyglucose (FDG) uptake in positron emission tomography (PET) suggested the existence of IVLBCL lung showing normal CT images. The diagnosis was confirmed random transbronchial biopsy, and then successfully treated. Since presenting PAH has rare is difficult to diagnose, early application...
BackgroundThe prognosis of locally advanced gastric cancer, such as clinical T4 disease, bulky nodal involvement, type 4 and large 3 remains unsatisfactory, even with D2 gastrectomy followed by adjuvant chemotherapy. One promising approach is neoadjuvant Combination chemotherapy S-1 oxaliplatin (SOX) recognised a potentially regimen for cancer. However, the use consisting SOX cancer has not been reported. The aim this study was to determine maximum tolerated dose (MTD) recommended...
In a phase III study of gemcitabine plus erlotinib for advanced pancreatic cancer conducted in Canada, the incidence interstitial lung disease (ILD) was 3.5 %. However, ILD reported as high 8.5 % Japanese II study. These results suggest influence ethnic factors association use with ILD. Here, we prospective to analyze relationship between human leukocyte antigen (HLA) alleles and patients receiving erlotinib. Patients were treated (1000 mg/m2; administered by intravenous infusion on days 1,...
Abstract Radiation therapy (RT) can enhance the abscopal effect of immune checkpoint blockade. This phase I/II study investigated efficacy and safety nivolumab plus RT in HER2-negative metastatic breast cancer requiring palliative for bone metastases. Cohort A included luminal-like disease, cohort B both triple-negative disease refractory to standard systemic therapy. Patients received 8 Gy single fraction metastasis on day 0. Nivolumab was administered 1 each 14-day cycle. In A, endocrine...
Summary As functional ABCB1 haplotypes were recently reported in the promoter region of gene, we resequenced distal region, along with other regions (the enhancer and proximal regions, all 28 exons), a total 533 Japanese subjects. Linkage disequilibrium (LD) analysis based on 92 genetic variations revealed 4 LD blocks same make up as previously described (Blocks −1, 1, 2 3), except that Block 1 was expanded to include new linkage between polymorphisms −1789G>A IVS5 + 123A>G intron 5...
Background The purpose of the study was to characterize pharmacokinetics mycophenolic acid (MPA) in Japanese heart transplant recipients and find time point that has best correlation with MPA area under plasma concentration curve (AUC). Methods Results Twenty-two treated mycophenolate mofetil were evaluated study. Approximately 9 months after transplantation, serum concentration-time from 0 12 h (AUC0-12 h) evaluated. AUC0-12 values cyclosporine (CsA) tacrolimus (FK) groups ranged 13.11...
Abstract Background Reports of hepatitis B virus (HBV) reactivation in solid tumors are very limited, and their frequencies risk factors were previously unknown. Aim To evaluate the prevalence HBV patients with resolved infection. Methods All 1088 assessed for eligibility; 251 had infection (negative HBs antigen positive anti‐HBc antibody and/or anti‐HBs antibody), HBV‐DNA was 243 these whom we analyzed reactivation. Risk exploratorily evaluated by analysis a case–control study. Results The...
On-site disinfection techniques are beneficial during a pandemic when there is marked shortage of personal protective equipment (PPE), as experienced the coronavirus disease 2019 outbreak. Ozone gas has been considered an alternative on-site disinfectant because it antimicrobial activities, can be produced from air by electricity without need for storage, and easily deactivated after use. However, ozone might become distributed at lower layer larger molecular weight than air. This study...
In general, drugs are used in accordance with an approved dosage regimen expectation of appropriate balance between efficacy and toxicity. However, dose control a narrow therapeutic range marked intersubject variability pharmacokinetics should be established through individualization dosing based on drug monitoring (TDM). The purpose this study was to examine differences the doses antiarrhythmic digoxin clinical practice influence TDM dosing.Prescription research performed at five national...
Hospitalized patients unable to ingest anything by mouth require nutritional support enteral feeding and administration of drugs through a nasogastric tube inserted into the digestive tract. Nasogastric amiodarone may not always be equivalent oral amiodarone.We collected 162 observations serum desethylamiodarone metabolite concentrations from 93 within 60 days starting treatment with amiodarone. Eight were given drug nasogastrically 85 patients, orally. The two groups, compared in terms...
The purpose of the study was to demonstrate how interaction between phenytoin and tacrolimus (FK 506) can be managed clinically characterize change in FK 506 levels after discontinuation two Japanese heart transplant recipients with different dosing periods ofphenytoin.A drug investigated 2 patients. concentration-dose ratios (CDR: trough blood level (ng/ml)/FK dose (mg/day) on previous day) were calculated as an index induction CYP3A4 enzyme during therapy.About 2- 3-fold dosages required...
While survival outcomes of early breast cancer cases have been improved remarkably in recent years, still many patients develop metastases and require the treatment against relapsed disease. The 10-year rate with advanced or metastatic cancer(A/MBC)is yet low level around 5%, despite probability disease silencing differs depending upon tumor subtype