Tetsuya Ueda
A5101963805- COVID-19 Clinical Research Studies
- Asthma and respiratory diseases
- Long-Term Effects of COVID-19
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac Imaging and Diagnostics
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and healthcare impacts
- Nanofabrication and Lithography Techniques
- Advancements in Photolithography Techniques
- Respiratory Support and Mechanisms
- Cardiac Ischemia and Reperfusion
- Inflammatory mediators and NSAID effects
- Dementia and Cognitive Impairment Research
- Gallbladder and Bile Duct Disorders
- Force Microscopy Techniques and Applications
- Cardiovascular Function and Risk Factors
- Peptidase Inhibition and Analysis
- Gout, Hyperuricemia, Uric Acid
- Allergic Rhinitis and Sensitization
- Cardiac Arrest and Resuscitation
- Gastric Cancer Management and Outcomes
- Neonatal Respiratory Health Research
- Pediatric Hepatobiliary Diseases and Treatments
Kyoto University
2003-2025
National Institute of Advanced Industrial Science and Technology
2024-2025
Saiseikai Nakatsu Hospital
2010-2025
Osaka Metropolitan University
2025
Tokyo Metropolitan University
2025
Osaka Institute of Technology
2024
Chiba University
2015-2022
Kyushu University
2007-2019
Kindai University
2018
Dai Nippon Printing (Japan)
2016
Airway wall thickening has been assumed to cause airway hyperresponsiveness, but a protective effect against narrowing also suggested. We investigated the relationship between thickness as assessed by helical computed tomography and two components of responsiveness, sensitivity reactivity, in patients with stable asthma (n = 23) without 22) inhaled steroid treatment. A cross-section apical bronchus right upper lobe was obtained. area corrected body surface measured an index thickness....
Asthma is characterised by chronic inflammation of the airways, but relevance high-sensitivity assays for C-reactive protein (hs-CRP), which are known to be a sensitive marker low-grade systemic inflammation, has not been fully studied in asthma. The objective was examine serum hs-CRP levels patients with asthma and their relationship clinical characteristics degree airway inflammation. Serum were cross-sectionally examined steroid-naive (n = 22) steroid-inhaling 23) adult healthy controls...
Oxidative stress is a critical mediator in liver injury of steatohepatitis. The transcription factor Nrf2 serves as cellular sensor and key regulator for induction hepatic detoxification antioxidative systems. involvement defense against the development steatohepatitis remains unknown. We aimed to investigate protective roles nutritional using wild-type (WT) gene-null ( Nrf2-null) mice. WT Nrf2-null mice were fed methionine- choline-deficient (MCD) diet 3 6 wk, tissues analyzed pathology...
Mechanisms underpinning the dysfunctional immune response in severe acute respiratory syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T B cell receptors (BCR) of >895,000 peripheral blood mononuclear cells from 73 disease 2019 (COVID-19) patients 75 healthy controls Japanese ancestry with host genetic data. COVID-19 showed a low fraction nonclassical monocytes (ncMono). report downregulated transitions classical to ncMono reduced CXCL10 expression...
A large cross sectional survey was carried out using a self administered questionnaire to examine the prevalence of laboratory animal allergy (LAA) and factors associated with its development. Out 5641 workers who were exposed animals at 137 facilities in Japan, 23.1% had one or more allergic symptoms related animals. The commonest symptom as rhinitis. About 70% LAA subjects developed during their first three years exposure. Atopy (past family history), number species handled, time spent...
Adherence to inhalation therapy is a critical determinant of the success chronic obstructive pulmonary disease (COPD) management. However, in practice, nonadherence very common COPD patients. The effects adherence have not been fully studied, and less known about relationship between medication quality life COPD. Our aim assess factors that contribute examine their correlation with life.A cross-sectional analysis 88 patients was performed using self-reported questionnaire responses on...
Adherence to inhalation therapy is a critical determinant of the success asthma management. Reasons for nonadherence have been well studied, but reasons good adherence are poorly understood. Understanding mechanisms important in developing strategies promote adherence. The objective this study was assess factors and that contribute clinical outcomes relating therapy.The related were examined cross-sectionally 176 adults with using self-reported questionnaire consisted four items dealing use...
Dyspnea on exertion (DOE) is a major symptom of chronic obstructive pulmonary disease (COPD) and difficult to control. This study was performed determine whether acupuncture superior placebo needling in improving DOE patients with COPD who are receiving standard medication.Sixty-eight 111 from the Kansai region Japan were diagnosed as having medication participated randomized, parallel-group, placebo-controlled trial (July 1, 2006, through March 31, 2009) which patients, evaluators,...
We aimed to elucidate differences in the characteristics of patients with coronavirus disease 2019 (COVID-19) requiring hospitalization Japan, by COVID-19 waves, from conventional strains Delta variant.We used secondary data a database and performed retrospective cohort study that included 3261 aged ≥ 18 years enrolled 78 hospitals participated Japan Task Force between February 2020 September 2021.Patients hospitalized during second (mean age, 53.2 [standard deviation {SD}, ± 18.9]) fifth...
<i>Background:</i> Cough variant asthma (CVA) is a phenotype of presenting solely with coughing, characterized by airway hyperresponsiveness, eosinophilic inflammation and cough response to bronchodilators. Leukotriene receptor antagonists (LTRAs) are antiasthma medications anti-inflammatory bronchodilatory properties. Although LTRAs exert antitussive effects in CVA, the mechanisms involved unknown. <i>Objectives:</i> This study aimed clarify CVA patients....
Abstract Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious that has caused millions of deaths, where comprehensive understanding mechanisms still unestablished. In particular, studies gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on thorough analysis whole blood RNA-seq data from 465 genotyped samples the Japan Task Force, including 359 severe 106 non-severe cases. We discover 1169 putative causal...
Cerebrospinal fluid (CSF) amyloid-β (Aβ)42 and tau are biomarkers for Alzheimer's disease (AD); however, the effects of other neurodegenerative processes on these remain unclear. We measured Aβ40, Aβ42, total tau, phosphorylated-tau, α-synuclein in CSF plasma using matched samples from various diseases to expand our basic knowledge their practical applications. A 213 183 were analyzed cognitively unimpaired subjects, patients with dementia (ADD), mild cognitive impairment (MCI), non-AD...
The coronavirus disease (COVID-19) pandemic is having a devastating effect worldwide. Host genome differences between populations may influence the severity of COVID-19. Japan COVID-19 Task Force conducting host analysis hospitalized patients with from more than 70 institutions nationwide in Japan. This report describes clinical characteristics enrolled to date. median (interquartile range) age 1674 included was 59 (45-71) years, and half (66.2%) were male. Less (41.2%) had severe disease....
Abstract Background Respiratory symptoms are associated with coronavirus disease 2019 (COVID-19) outcomes. However, the impacts of upper and lower respiratory on COVID-19 outcomes in same population have not been compared. The objective this study was to characterize compare their hospitalized patients. Methods This a multicenter, retrospective cohort study; database from Japan Task Force used. A total 3314 patients were included study, data collected. participants classified according...
Patients with cough variant asthma, a common cause of chronic cough, may develop wheezing. We examined the determinants this phenomenon and achievement remission in 42 patients. During 4 years after diagnosis, wheezing developed 13 Early inhaled corticosteroid treatment was inhibitory against development by univariate analysis multivariate an odds ratio 0.12 (95% confidence interval, 0.02 to 0.87, p = 0.037). Remission achieved 7 patients, who were younger than those without (p 0.048)....