A5030149147- Effects and risks of endocrine disrupting chemicals
- Carcinogens and Genotoxicity Assessment
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Toxic Organic Pollutants Impact
- Respiratory Support and Mechanisms
- Drug-Induced Adverse Reactions
- Computational Drug Discovery Methods
- Pesticide Exposure and Toxicity
- Intensive Care Unit Cognitive Disorders
- Pharmacy and Medical Practices
- Sulfur Compounds in Biology
- Metabolism and Genetic Disorders
- Pharmacological Effects and Toxicity Studies
- Tea Polyphenols and Effects
- Heavy Metal Exposure and Toxicity
- Pharmaceutical studies and practices
- Hormonal Regulation and Hypertension
- Peroxisome Proliferator-Activated Receptors
- Nosocomial Infections in ICU
- Musculoskeletal pain and rehabilitation
- Pharmacovigilance and Adverse Drug Reactions
- Balance, Gait, and Falls Prevention
- Water Treatment and Disinfection
- Stroke Rehabilitation and Recovery
Mitsubishi Chemical (Japan)
1996-2023
Chubu University
2014-2021
National Institute of Technology and Evaluation
2012-2018
National Hospital Organization Mito Medical Center
2015-2018
Chemicals Evaluation and Research Institute
2013-2017
University of Tsukuba
2016-2017
National Institute of Health Sciences
2005-2016
Tosei General Hospital
2006-2016
Mitsubishi Chemical Group Science and Technology Research Center (Japan)
2015
Biotest (United States)
2013
Introduction: Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening severe cutaneous adverse reactions. Recently, strong associations of HLA-B*1502 HLA-B*5801 with carbamazepine- allopurinol-induced reactions were found in Han Chinese patients, respectively, ethnic differences the have been reported. The objective this study is to clarify involvement Japanese SJS/TEN patients. Methods: HLA-B genotyping was performed on 58 patients between July 2006...
Summary Stevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life‐threatening severe cutaneous adverse reactions. Recently, strong associations of HLA‐B*1502 with carbamazepine‐induced SJS/TEN have been found in Han Chinese patients. These confirmed several Asian populations, excluding Japanese. SJS patients carrying HLA‐B*1508, HLA‐B*1511, or HLA‐B*1521, which members the HLA‐B75 type along HLA‐B*1502, were detected studies India Thailand. In current study, we...
Gemcitabine is rapidly metabolized to its inactive metabolite, 2',2'-difluorodeoxyuridine (dFdU), by cytidine deaminase (CDA). We previously reported that a patient with homozygous 208A alleles of CDA showed severe adverse reactions an increase in gemcitabine plasma level. This study extended the investigation effects genetic polymorphisms on pharmacokinetics and toxicities.Genotyping was performed direct sequencing DNA obtained from peripheral blood Japanese gemcitabine-naïve cancer...
The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016), a Japanese-specific set clinical practice guidelines sepsis septic shock created jointly by the Society Intensive Care Medicine Association Acute Medicine, was first released in February 2017 published Journal JSICM, [2017; Volume 24 (supplement 2)] https://doi.org/10.3918/jsicm.24S0001 28, 1)] http://onlinelibrary.wiley.com/doi/10.1002/jja2.2017.28.issue-S1/issuetoc . This abridged...
We investigate the dispersion of polymer-grafted particles suspended in a polymer matrix by viscoelastic measurements and electron microscopy. find that, when graft density is low, particle improves with an increase density, while becomes worse too high; i.e., there optimum for dispersing particles. explain phenomena showing that grafted polymers cause attraction high density.
Summary The effect of heat treatment on changing the color light-irradiated wood was investigated. change in lightness, ∆L*, with much greater than that unirradiated wood. chroma coordinates, ∆a*, irradiated increased temperature and time. ∆b* decreased after showing a sharp increase short period treatment. It is thought changes are related to chemical composition which accelerated by heat. With low treatment, changed remarkably high relative humidity. Little observed Therefore, presence...
Ethnic differences in genetic polymorphisms UDP-glucuronosyltransferase 1A1 (<i>UGT1A1</i>) were investigated among African-Americans, Caucasians, and Japanese using samples obtained from 150 individuals for each population. Genotyping of –3279T>G the phenobarbital-responsive enhancer module, TA repeats TATA box, 211G>A (G71R) 686C>A (P229Q) exon 1, three single nucleotide (SNPs) (1813C> T, 1941C>G, 2042C>G) 3′-untranslated region 5 was performed. Eight haplotypes block 1...
We performed comprehensive haplotyping of ABCB1/MDR1 gene blocks using 49 genetic polymorphisms, including seven novel ones, obtained from 145 Japanese subjects. The was divided into four (Blocks -1, 1, 2, and 3) based on linkage disequilibrium analysis polymorphisms. Using an expectation-maximization program, 8, 3 haplotype groups (3, 12, 32, 18 haplotypes) were identified in Blocks 3, respectively. Within Block *1, *2, *4, *6, *8 reported by Kim colleagues (Clin Pharmacol Ther 2001;...
Background and Objective The outcome of acute exacerbation idiopathic pulmonary fibrosis (AE-IPF) is usually very poor, it has been suggested that mechanical ventilation does not benefit AE-IPF patients. Noninvasive (NIV) attracted attention as a means to avoid intubation in respiratory failure, including distress syndrome (ARDS). This study describes the patients with who were treated NIV. Methods Patients included those fulfilled criteria for during periods between April 1998 June 2004 at...
Objective: To determine the thresholds of lower extremity muscle strength below which performing activities daily living (ADL) is impaired in older adults. Design: Cross-sectional. Setting: Community. Subjects: Forty-nine adults (81—89 years) were divided into an independent group (n = 25) who needed no assistance and a dependent 24) to perform ADL. Interventions: Not applicable. Main measures: Functional independence measures level disability muscular hip flexors, extensors, knee extensors...
Background and Purpose The Japanese Clinical Practice Guidelines for Management of Sepsis Septic Shock 2016 (J‐ SSCG 2016), a Japanese‐specific set clinical practice guidelines sepsis septic shock created jointly by the Society Intensive Care Medicine Association Acute Medicine, was first released in February 2017 Japanese. An English‐language version these based on contents original Japanese‐language version. Methods Members were selected organized into 19 committee members 52 working group...
Metabolism of administered drugs is determined by expression and activity many drug-metabolizing enzymes, such as the cytochrome P450 (P450s) family members. Pregnane X receptor (PXR) a master transcriptional regulator drug/xenobiotic-metabolizing including P450s drug transporters. In this study, we describe functional analysis four naturally occurring human PXR (hPXR) variants (R98C, R148Q, R381W, I403V) that have recently identified. By reporter gene assay using <i>CYP3A4</i>...
8-Hydroxydeoxyguanosine (8-OH-dG) levels were examined in liver and kidney DNA after di(2-ethylhexyl)phthalate (DEHP), di(2-ethylhexyl)adipate (DEHA) phthalic anhydride administration to male 6-week-old F-344 rats the diet at concentrations of 1.2, 2.5 1.5%, respectively. Significant increases 8-OH-dG observed only (target organ DEHP DEHA carcinogenesis) 1 2 weeks treatment with DEHA, The results suggest involvement oxidative damage hepatocarcinogenesis by peroxisome proliferators.
Aim: This preliminary study investigated genomic biomarkers for Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), related to three antiepileptic drugs, zonisamide, phenobarbital phenytoin. Patients & methods:HLA class I HLA-DRB1 loci were genotyped Japanese patients with zonisamide-, phenobarbital- or phenytoin-induced SJS/TEN (n = 12, 8 9, respectively) healthy volunteers 2878). Results: Carrier frequencies of HLA-A*02:07 in zonisamide-induced the general population 41.7...
Much evidence has been documented supporting the hypothesis that down-regulation of gap junctional intercellular communication (GJIC) is a cellular event underlying tumor promotion process and treatment to prevent or up-regulate GJIC important in preventing promotion. We explored potential preventive effects green tea against promoting action pentachlorophenol (PCP) mouse hepatocarcinogenesis, examining whether drinking prevents inhibition liver caused by tumorigenic doses PCP. used modified...
An expert meeting was organized by the World Health Organization (WHO) and held in Stockholm on 15-18 June 1997. The objective of this to derive consensus toxic equivalency factors (TEFs) for polychlorinated dibenzo-p-dioxins (PCDDs) dibenzofurans (PCDFs) dioxinlike biphenyls (PCBs) both human, fish, wildlife risk assessment. Based existing literature data, TEFs were (re)evaluated either revised (mammals) or established (fish birds). A few mammalian WHO-TEFs revised, including...
The roles of glutathione (GSH), cysteine, vitamin C., liposome‐encapsulated superoxide dismutase (L‐SOD) and E in preventing oxidative DNA damage cytotoxicity the rat kidney after administration potassium bromate (KBrO 3 ) to male F344 rats were investigated by measuring 8‐hydroxydeoxyguanosine (8‐OH‐dG), an product, lipid peroxidation (LPO) levels relative weight (RKW). Combined pre‐ posttreatment animals with 2 × 800 mg/kg GSH i.p. inhibited increase 8‐OH‐dG, LPO RKW caused 80 KBrO...
We investigated single-nucleotide polymorphisms of the cytidine deaminase gene (CDA), which encodes an enzyme that metabolizes gemcitabine, to clarify relationship between polymorphism 208G>A and pharmacokinetics toxicity gemcitabine in cancer patients treated with plus cisplatin.Six Japanese cisplatin were examined. Plasma its metabolite 2',2'-difluorodeoxyuridine measured using high-performance liquid chromatography method, CDA genotypes determined DNA sequencing.One patient, a 45-year-old...
We propose a new simulation scheme to describe polymer dynamics at interfaces. Using this scheme, we studied adsorption in solution. calculated the evolution of density profiles and conformation. The numerical results are qualitatively consistent with recent experimental observations.