A5041401659- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Soft tissue tumor case studies
- Chromatin Remodeling and Cancer
- Vascular Tumors and Angiosarcomas
- Pancreatic and Hepatic Oncology Research
- Renal cell carcinoma treatment
- Tumors and Oncological Cases
- Cancer-related gene regulation
- Neurofibromatosis and Schwannoma Cases
- Neuroendocrine Tumor Research Advances
- Oral and Maxillofacial Pathology
- Cancer and Skin Lesions
- Cancer Genomics and Diagnostics
- Ear and Head Tumors
- IgG4-Related and Inflammatory Diseases
- Gastric Cancer Management and Outcomes
- Cardiac tumors and thrombi
- Salivary Gland Tumors Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Renal and related cancers
- Cancer-related Molecular Pathways
- Cancer Mechanisms and Therapy
- Cell Adhesion Molecules Research
- Lymphoma Diagnosis and Treatment
Kitakyushu Municipal Medical Center
2015-2024
Kyushu University
2005-2014
National Hospital Organization Kyushu Cancer Center
2004-2011
Pathological Society
2006
Fukuoka University
2003-2004
Aso Iizuka Hospital
2002
Kumamoto University
2001-2002
Job Performance Systems (United States)
2002
Matsuyama Red Cross Hospital
2001
Matsuyama University
2001
Extragastrointestinal stromal tumor (EGIST) is a unique that occurs outside the gastrointestinal tract. EGIST shows c-kit expression and histologic appearance similar to those of (GIST). Most GISTs have gain-of-functional mutation gene, some platelet-derived growth factor receptor-alpha (PDGFRA) gene. However, frequency genes in EGISTs remains unclear. We examined clinicopathologic features, prognostic factors, PDGFRA 39 cases EGIST. Tumors with high mitotic counts (>or=5/50 power fields) or...
Several previous studies have demonstrated the lack of SMARCB1/INI1 protein expression in only malignant rhabdoid tumor (MRT). sarcoma groups are associated with a tumor-specific translocation involving EWS. Moreover, EWS and genes located on same 22q chromosome. We analyzed status 93 cases sarcomas chromosomal EWS, comprising 52 Ewing's sarcoma/primitive neuroectodermal tumors, 24 extraskeletal myxoid chondrosarcomas (EMCS), 14 clear cell soft tissue, 2 desmoplastic small round 1...
Pleomorphic leiomyosarcoma (PLMS) was recently described as a morphologic variant of leiomyosarcoma; however, its diagnostic criteria, shown by features and biologic behavior, remain controversial. We describe 28 cases pleomorphic sarcoma with areas in more than two thirds the tumor an ordinary leiomyosarcomatous fascicular area covering less one third PLMS. PLMS comprised 8.6% all leiomyosarcomas (322 cases) registered our institute. Patients ranged age from 31 to 89 years (average, 57.9...
This study addresses the immunohistochemical expression of E-cadherin and catenin families mutations beta-catenin gene detected by PCR-SSCP in synovial sarcoma. Immunohistochemical analysis was performed for 72 cases, with follow-up data available on 62. The prognostic value these proteins evaluated. Reduced immunoreactivity alpha-catenin significantly correlated a poor survival rate (p=0.0040 0.0053, respectively). According to multivariate analysis, low AJC stage (stages I II: p<0.0001),...
We report a case of renal angiomyolipoma (AML) with malignant transformation. A 28-year-old woman developed large bilateral masses 5 months before admission to our hospital. She was diagnosed tuberous sclerosis when she 4 years old. Total nephrectomy the left kidney performed, but died during operation. Although focal region resected tumor had appearance classic AML, most lesion showed diffuse proliferation atypical epithelioid cells resembling that in cell carcinoma. The extremely...
The immunohistochemical expression of β-catenin, cyclin D1, Ki-67 and PCNA was Examined in 38 cases sporadic extra-abdominal or abdominal-wall desmoid tumours without familial adenomatous polyposis (FAP), to evaluate the hypothesis that accumulated β-catenin within nuclei could affect regulation D1 gene. There a statistically significant correlation between accumulation overexpression (p=0.029). Each group with showed higher PCNA-LI than those without, difference being (p=0.007, p=0.004,...
Clinicopathological prognostic factors in soft tissue leiomyosarcoma: a multivariate analysis Aims: Prognostic affecting survival cases of leiomyosarcoma parts were investigated this study. Methods and results: A retrospective study 267 patients was carried out. This group comprised 142 females (53%) 125 males (47%), whose ages ranged from 7 to 95 years (median 58 years). One hundred five superficially situated (arising the skin or subcutis), while remaining 162 deeply (subfacial). Nineteen...
Recently, the category of malignant fibrous histiocytoma (MFH) has been under discussion and new entities resembling MFH have appeared. To clarify recent situation regarding MFH, we reassessed previously diagnosed cases in accordance with most up-to-date diagnostic criteria, which included allied tumors. We carefully 428 that had our institute during past 28 years. Moreover, searched for clinicopathological prognostic factors among were finally as MFH. Among cases, 138 their diagnoses...
Aims: The pathogenic mechanism and predictive indicators of biological behaviour inflammatory myofibroblastic tumour are poorly understood. We investigated molecular abnormalities p53 MDM2 in order to assess whether these play an important role pathogenesis, they also contribute clinicopathological aggressive phenotype tumour. Methods results: compared the immunohistochemical expression calponin, h‐caldesmon, ALK, gene mutation amplification with findings 15 cases Histologically, cellular...
In myxoid/round cell liposarcoma (MLS/RCLS), the presence of a round (RC) component has been reported to correlate with worse prognosis for patients. However, little is known about molecular genetic differences between conventional myxoid (MX) components and RC in this tumour. The aim study was investigate possible implications alterations G1 S-phase check-point genes, especially component. We evaluated immunohistochemical expression p53, MDM2, p14 p16 protein assessed proliferative...
Aims: Low‐grade fibromyxoid sarcoma (LGFMS) is a distinctive variant of fibrosarcoma and has been reported to have metastatic potential despite its low‐grade histological findings. myxofibrosarcoma (MFS) an important differential diagnosis LGMFS, because it shows different biological behaviour. Of 75 MFSs in the extremities trunk, we defined 22 grade 1 tumours as MFS according French Federation Cancer Centres grading system compared clinicopathological factors immunohistochemical expression...
The aim of this study was to investigate the potential role HER-2/neu in stepwise progression carcinoma ex pleomorphic adenoma (CXPA) and evaluate its prognostic significance CXPA. We examined HER2 overexpression amplification by immunohistochemistry chromogenic in-situ hybridization 31 cases CXPA with ductal differentiation (eight intraductal, five intracapsular, 18 extracapsular) seven atypical (PA). were found 17 (54.8%) 12 (38.7%) cases, respectively. more prevalent extracapsular CXPAs...
In this study, we aimed to investigate the molecular mechanisms underlying development of mucoepidermoid carcinoma (MEC).In 31 cases, examined MAML2 fusion status using reverse transcriptase-polymerase chain reaction, and HER2 EGFR immunohistochemistry chromogenic in-situ hybridization. fusions were detected in 15 (57.7%) 26 MECs analysed, including 11 16 (68.8%) low-grade, two four (50%) intermediate-grade six (33.3%) high-grade MECs. gene amplification an increased copy number (with...
p14(ARF), p15(INK4b), and p16(INK4a) are tumor suppressor genes that located closely at 9p21 often coinactivated by genetic or epigenetic alterations. Malignant peripheral nerve sheath (MPNST) is a rare sarcoma with poor prognosis. However, the prognostic implications of inactivation in MPNSTs have not been adequately investigated. Here we carried out genetic, epigenetic, expression analysis p16(INK4a), clarified significance their MPNSTs.p14(ARF), protein expressions were assessed...
Aims: Only a few reports on renal cell carcinoma with rhabdoid features have been published. This study was performed to investigate the clinicopathological characteristics of carcinomas features. Methods and results: Among 253 cases in adults, eight were detected. Rhabdoid areas ranged from 10% 90% each cases. Seven TNM stage III or IV, four died within 8 months surgery. Immunohistochemically, positive for CAM 5.2 (4/8), AE1/AE3 (6/8), epithelial membrane antigen (6/8) vimentin (8/8),...
Rhabdomyosarcoma is the most commonly occurring soft-tissue sarcoma in children. Some reports have discussed altered expression and molecular abnormalities of cell-cycle-regulatory proteins rhabdomyosarcoma; however, variable frequencies occurrence been noted. In current study, among 72 cases rhabdomyosarcoma, authors evaluated for p53, MDM2, p16, p21/WAF1, p27, cyclin D1, E, pRb E2F-1 protein immunohistochemically assessed proliferative activities using MIB-1. We also analyzed mutation p53...
Abstract The p16 INK4a tumour suppressor gene, encoding protein, plays a crucial role in regulation of the G1 cell‐cycle phase. To investigate potential soft tissue leiomyosarcoma (LMS), an immunohistochemical analysis was performed 77 LMSs for expression. Decreased expression protein identified 25 (32%). correlated significantly with large size ( p = 0.0038). In univariate analysis, and decreased were statistically significant adverse prognostic factors 0.025 0.0021, respectively)....
The expression of basic fibroblast growth factor (bFGF) and receptor (FGFR) mRNA was examined in gastric carcinomas by immunohistochemistry situ hybridization, respectively. In the 20 advanced examined, bFGF found 14 (70.0 per cent) confined to tumour cells, whereas FGFR demonstrated 12 (60.0 seen both cells endothelial cells. mRNA-positive were larger, more frequently classified as undifferentiated adenocarcinoma, invaded serosal layer, had a higher rate lymph node metastases than...