A5054549197- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Urinary Tract Infections Management
- Thyroid Cancer Diagnosis and Treatment
- Receptor Mechanisms and Signaling
- Sarcoma Diagnosis and Treatment
- Nephrotoxicity and Medicinal Plants
- Cancer-related Molecular Pathways
- Genetic factors in colorectal cancer
- Neuroscience and Neuropharmacology Research
- Cervical Cancer and HPV Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Endometriosis Research and Treatment
- Gastric Cancer Management and Outcomes
- Peptidase Inhibition and Analysis
- Colorectal Cancer Treatments and Studies
- Cancer-related molecular mechanisms research
- Pediatric Urology and Nephrology Studies
- Neuroendocrine Tumor Research Advances
- Neuropeptides and Animal Physiology
- Cancer Cells and Metastasis
- Colorectal Cancer Screening and Detection
- HER2/EGFR in Cancer Research
Tokyo National Hospital
2016-2025
Nippon Medical School
2019-2025
Municipal Tsuruga Hospital
1998-2025
National Cancer Center
2011-2025
Tokai University
2020-2024
Shionogi (Japan)
1993-2024
National Cancer Center Hospital East
2016-2024
National Cancer Centre Japan
2024
Futaba (Japan)
2005-2024
Yokohama Municipal Citizen's Hospital
2015-2023
Next-generation sequencing (NGS) of tumor tissue (ie, clinical sequencing) can guide management by providing information about actionable gene aberrations that have diagnostic and therapeutic significance. Here, we undertook a hospital-based prospective study (TOP-GEAR project, 2nd stage) to investigate the feasibility utility NGS-based analysis 114 cancer-associated genes (the NCC Oncopanel test). We examined 230 cases (comprising more than 30 types) advanced solid tumors, all which were...
Foxp3-expressing CD25+CD4+ regulatory T cells (Tregs) are abundant in tumor tissues. Here, hypothesizing that Tregs would clonally expand after they activated by tumor-associated antigens to suppress antitumor immune responses, we performed single-cell analysis on characterize them cell receptor clonotype and gene-expression profiles. We found multiclonal present tissues predominantly expressed the chemokine CCR8. In mice humans, CCR8+ constituted 30 80% of various cancers less than 10%...
4006 Background: BTCs have an aggressive tumor biology with limited treatment options. With a HER2-positivity rate of 5–20% in BTCs, case series and small clinical trials shown signs activity for HER2 blockade these pts. T-DXd is antibody-drug conjugate composed humanized monoclonal anti-HER2 antibody, cleavable linker, topoisomerase I inhibitor. The HERB trial investigator-initiated, multicenter, single-arm phase 2 pts HER2-expressing BTCs. Methods: Centrally confirmed (HER2-positive: IHC3+...
PURPOSE To investigate the efficacy and safety of trastuzumab deruxtecan, an antibody-drug conjugate targeting human epidermal growth factor receptor 2 (HER2) with a topoisomerase I inhibitor payload, in patients uterine carcinosarcoma (UCS) expressing HER2. PATIENTS AND METHODS Patients recurrent UCS HER2 immunohistochemistry scores ≥1+ previously treated chemotherapy were included. assigned to HER2-high (immunohistochemistry score ≥2+; n = 22) or low 1+; 10) groups for primary exploratory...
Journal Article Association of Serum Antithyroid Antibodies with Lymphocytic Infiltration the Thyroid Gland: Studies Seventy Autopsied Cases Get access HIROSHI YOSHIDA, YOSHIDA 1Department Pathology I, School Medicine, Iwate Medical University, Morioka; and Central Laboratory for Clinical Investigation, Osaka University Hospital Osaka, Japan Search other works by this author on: Oxford Academic Google Scholar NOBUYUKI AMINO, AMINO KANICHI YAGAWA, YAGAWA KUNINORI UEMURA, UEMURA MASANOBU...
Recent studies have demonstrated that BRAFV600E mutation is a common event in papillary thyroid carcinoma and majority of these lesions shown direct relationship between aggressive characteristics, including worse patient prognosis. However, there are no from Japan regarding this issue large series with adequate postoperative follow-up periods. We investigated 631 patients having median periods 83 months. The prevalence was 38.4%, the rate higher larger than 1.0 cm but did not successively...
Abstract We analyzed the bilirubin uridine diphosphate‐glucuronosyltransferase (B‐UGT) gene in 42 Japanese newborns with hyperbilirubinemia and determined that 21 infants were heterozygous while 3 was homozygous for Gly71Arg. Allele frequency of Gly71Arg 0.32 hyperbilirubinemia, which significantly higher than 0.13 healthy controls. This mutant allele is also prevalent among Korean Chinese controls a 0.23 both populations. However, this mutation not detected 50 German These data suggest high...
We report herein the discovery of human immunodeficiency virus type-1 (HIV-1) integrase inhibitors dolutegravir (S/GSK1349572) (3) and S/GSK1265744 (4). These drugs stem from a series carbamoyl pyridone analogues designed using two-metal chelation model catalytic active site. Structure-activity studies evolved tricyclic pyridines that demonstrated properties indicative once-daily dosing superior potency against resistant viral strains. An inherent hemiaminal ring fusion stereocenter within...
Rationale: Respiratory syncytial virus (RSV) induces not only infantile recurrent wheezing but also potentially atopic asthma.Objectives: To test the effect of RSV infection on development subsequent asthma, we evaluated whether palivizumab, an anti-RSV monoclonal antibody, by preventing severe disease in first year life, could impact and asthma at 6 years age.Methods: During 2007 to 2008 season, decision administer palivizumab was made based standard medical practice observational...
The aim of this study was to clarify the prognostic factors intrahepatic cholangiocarcinoma (ICC) following hepatectomy and examine impact lymph node metastasis on survival. This therefore carried out as a Project Study Japanese Society Hepato-Biliary-Pancreatic Surgery.Three hundred forty-one patients who underwent for ICC between 1995 2004 at 9 institutions Medical University Hospitals were analyzed retrospectively. Multivariate regression analyses Kaplan-Meyer analysis performed identify...
The molecular mechanisms underlying the serrated pathway of colorectal tumourigenesis, particularly those related to traditional adenomas (TSAs), are still poorly understood. In this study, we analysed genetic alterations in 188 polyps, including hyperplastic sessile adenomas/polyps (SSA/Ps), TSAs, tubular adenomas, and tubulovillous by using targeted next-generation sequencing reverse transcription-PCR. Our analyses showed that most TSAs (71%) contained WNT components. particular,...
Phyllodes tumours are rare fibroepithelial of the breast, that include benign, borderline, and malignant lesions. Although molecular basis phyllodes largely remains unknown, a recent exome study identified MED12 mutations as sole recurrent genetic alteration in fibroadenoma, common benign tumour shares some histological features with tumour. Forty-six 58 fibroadenomas breast were analysed for by using Sanger sequencing. 37 out 46 (80%). The prevalence was similar among (15/18, 83%),...
Trastuzumab deruxtecan (DS-8201) is an antibody–drug conjugate composed of a humanized monoclonal anti-HER2 antibody, cleavable tetrapeptide-based linker and potent topoisomerase I inhibitor. The drug's efficacy has been proven in HER2-positive breast gastric cancers. rate HER2 positivity biliary tract cancer (BTC) reported to be 5–20%, case reports clinical trials have suggested that inhibitors might active BTC. Here we describe the rationale design phase II HERB trial will evaluate safety...
Abstract Regulatory T cells (Tregs) suppress the host immune response and maintain homeostasis. Tregs also promote cancer progression are involved in resistance to checkpoint inhibitor treatments. Recent studies identified selective CCR8 expression on tumor-infiltrating Tregs; CCR8+ have been indicated as a possible new target of immunotherapy. Here, we investigated features lung patients. were highly activated infiltration tumors was associated with poor prognosis We their suppressive...
PURPOSE Treatment options for patients with unresectable or recurrent biliary tract cancer (BTC) who progress on a gemcitabine-containing regimen are limited. In addition, the significance of anti–human epidermal growth factor receptor 2 (HER2) therapy in HER2-expressing BTC has not been sufficiently investigated. METHODS this phase II trial, participants from five institutions Japan were enrolled. Eligible had pathologically confirmed centrally HER2-positive (immunohistochemistry [IHC]3+...
Ovarian clear cell carcinoma (OCCC) is a gynecological cancer with dismal prognosis; however, the mechanism underlying OCCC chemoresistance not well understood. To explore intracellular networks associated chemoresistance, we analyze surgical specimens by performing integrative analyses that combine single-cell and spatial transcriptomics. We find chemoresistant subpopulation elevated HIF activity localizes mainly in areas populated cancer-associated fibroblasts (CAFs) myofibroblastic...
Optimal management of postoperative radiotherapy for patients with completely resected thymoma remains controversial. This study was conducted to assess the efficacy mediastinal irradiation in thymoma.The records 103 who received during period between 1979 and 1998 were reviewed. The distribution according Masaoka stage Stage I 17 patients, II 61 III 25 patients. Fifty-two treated involved field (IF) irradiation, 51 whole or without boost (WM irradiation). total radiation dose primary tumor...
This work is a continuation of our initial discovery potent monocyclic carbamoyl pyridone human immunodeficiency virus type-1 (HIV-1) integrase inhibitor that displayed favorable antiviral and pharmacokinetic properties. We report herein series bicyclic analogues to address conformational issues from SAR studies. modification the core unit succeeded deliver low nanomolar potency in standard assays. An additional hydroxyl substituent on scaffold provides remarkable improvement efficacies...