A5042739835- Head and Neck Cancer Studies
- Immunotherapy and Immune Responses
- Oral and Maxillofacial Pathology
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- vaccines and immunoinformatics approaches
- Cancer Immunotherapy and Biomarkers
- Salivary Gland Tumors Diagnosis and Treatment
- Multimodal Machine Learning Applications
- Head and Neck Surgical Oncology
- NF-κB Signaling Pathways
- Ear and Head Tumors
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer Diagnosis and Treatment
- Topic Modeling
- Cancer-related gene regulation
- Oral health in cancer treatment
- Immune Cell Function and Interaction
- Neonatal Respiratory Health Research
- Cytokine Signaling Pathways and Interactions
- Salivary Gland Disorders and Functions
- Advanced Radiotherapy Techniques
- Peptidase Inhibition and Analysis
- Bone Tumor Diagnosis and Treatments
Kumamoto University
2016-2025
The University of Tokyo
1994-2024
Ochanomizu University
2023
Tokyo Institute of Technology
2022
University of California, Los Angeles
2022
Kumamoto University Hospital
2009-2021
National Hospital Organization Kyushu Cancer Center
1995-2020
Japan Clinical Cancer Research Organization
2020
Fukuoka Children's Hospital and Medical Center for Infectious Diseases
2007-2008
Konan University
2007
Rationale: Respiratory syncytial virus (RSV) induces not only infantile recurrent wheezing but also potentially atopic asthma.Objectives: To test the effect of RSV infection on development subsequent asthma, we evaluated whether palivizumab, an anti-RSV monoclonal antibody, by preventing severe disease in first year life, could impact and asthma at 6 years age.Methods: During 2007 to 2008 season, decision administer palivizumab was made based standard medical practice observational...
The biological effect of interleukin-6 (IL-6) signaling in oral squamous cell carcinoma (OSCC) and whether IL-6 receptor (IL-6R)-mediated can be a therapeutic target for OSCC are unclear. aim this study was to investigate the effects inhibition IL-6R-mediated on progression evaluate availability tocilizumab, humanized antihuman IL-6R antibody, as agent OSCC.We evaluated expression levels 58 tissues 4 lines by real-time quantitative reverse transcription-PCR and/or immunohistochemstry. We...
The peptides derived from ideal cancer-testis antigens, including LY6K, CDCA1, and IMP3 (identified using genome-wide cDNA microarray analyses), were used in immunotherapy for head neck squamous cell cancer (HNSCC). In this trial, we analyzed the immune response to safety efficacy of vaccine therapy.A total 37 patients with advanced HNSCC enrolled trial peptide therapy, OS, PFS, immunologic evaluated enzyme-linked ImmunoSpot (ELISPOT) pentamer assays. subcutaneously administered weekly IFA....
In promoting tumour malignancy IL-6 signalling is considered to have an important role. However, the biological roles of on radiosensitivity in oral squamous cell carcinoma (OSCC) remain largely unclear. The objective this study determine effects and molecular mechanisms OSCC.Two OSCC lines, tissue samples with radioresistant cells were used. We examined IL-6, or tocilizumab, a humanised anti-human receptor antibody, both DNA damage after X-ray irradiation vitro. addition, we investigated...
N6-Methyladenosine (m6A) modification is the major chemical in mRNA that controls fundamental biological processes, including cell proliferation. Herein, we demonstrate fat mass and obesity-associated (FTO) demethylates m6A of cyclin D1, key regulator for G1 phase progression proliferation vitro vivo. FTO depletion upregulates D1 modification, which turn accelerates degradation mRNA, leading to impairment progression. oscillates a cell-cycle-dependent manner; levels are suppressed during...
BACKGROUND It has been reported that the transcription factor nuclear κB (NF-κB) is involved in growth, invasion, and antiapoptotic activity of cultured tumor cells. METHODS The authors used immunohistochemistry to examine expression NF-κB signaling molecules leading activation 36 untreated biopsy specimens from patients with squamous cell carcinoma (SCC) 15 epithelial dysplasia oral cavity. RESULTS Among examined, p65 subunit (p65) IκB kinase α (IKKα) were expressed...
It has been reported that the transcription factor nuclear kappaB (NF-kappaB) is involved in growth, invasion, and antiapoptotic activity of cultured tumor cells.The authors used immunohistochemistry to examine expression NF-kappaB signaling molecules leading activation 36 untreated biopsy specimens from patients with squamous cell carcinoma (SCC) 15 epithelial dysplasia oral cavity.Among examined, p65 subunit (p65) IkappaB kinase alpha (IKKalpha) were expressed highly almost all SCC whereas...
Abstract Targeting the function of membrane transporters in cancer stemlike cells is a potential new therapeutic approach. Cystine‐glutamate antiporter xCT expressed CD44 variant (CD44v)‐expressing contributes to resistance oxidative stress as well therapy through promoting glutathione (GSH)‐mediated antioxidant defense. Amino acid transport by might, thus, be promising target for treatment, whereas determination factors cell sensitivity xCT‐targeted remain unclear. Here, we demonstrate that...
Abstract Lymph node metastasis is associated with resistance to conventional therapy and poor survival of patients oral squamous cell carcinoma (OSCC). Although lymphangiogenesis well known be the occurrence lymph in various cancers, precise mechanisms OSCC are largely unknown. IL‐6, a potent pro‐inflammatory cytokine, has been shown play active roles including OSCC. This study aimed investigate involvement IL‐6 signalling lymphatic evaluate efficacy tocilizumab, humanized anti‐human...
Resistance to 5-fluorouracil (5-FU) is a major obstacle in treating oral squamous cell carcinoma (OSCC). However, little known about apoptosis resistance, which contributes 5-FU resistance OSCC.We focussed on the cellular inhibitor of protein 2 (cIAP2) basis DNA microarray data using parental and 5-FU-resistant OSCC lines. The effects cIAP2 downregulation sensitivity were evaluated. An immunohistochemical analysis related proteins, cIAP1 X-linked IAP, was performed 54 patients who treated...
The Neutrophil to lymphocyte ratio (NLR) has prognostic value in patients with a variety of cancers. However, its significance oral squamous cell carcinoma (OSCC) not been fully explored. purpose this study was determine the clinical NLR OSCC. OSCC who underwent surgery following 5-fluorouracil (5-FU)-based chemoradiotherapy were enrolled study. associations between status and various clinicopathological features examined, effects on prognosis evaluated. Analysis circulating interleukin-6...
The tumor-associated microenvironment has been shown to protect tumor cells from treatment, and the extracellular matrix (ECM) is known affect drug resistance as a key regulator of microenvironment. However, little about cell adhesion-mediated (CAM‑DR) due cell-ECM contact in patients with oral squamous carcinoma (OSCC). In present study, we evaluated ECM molecule fibronectin (FN) using DNA microarray data obtained parental 5-FU-resistant OSCC lines. We investigated effects adhesion FN on...
IL6 produced by tumor cells promotes their survival, conferring a poor prognosis in patients with cancer. also contributes to immunosuppression of CD4+ T cell-mediated antitumor effects. In this study, we focused on the impact trans-signaling mediated soluble receptors (sIL6R) expressed tumor-bearing hosts. Higher levels sIL6R circulating blood were observed mice, whereas systemic increase was not prominent mice myeloid cell-specific conditional deletion IL6R even when sIL6R. Abundant...
The CD169+ macrophages in lymph nodes are implicated cytotoxic T lymphocyte (CTL) activation and associated with improved prognosis several malignancies. Here, we investigated the significance of oral squamous cell carcinoma (OSCC). Further, tested anti-tumor effects naringenin, which has been previously shown to activate macrophages, a murine OSCC model. Immunohistochemical analysis for CD169 CD8 was performed on node primary tumor specimens from 89 patients OSCC. We also evaluated...
Nuclear factor erythroid 2-related 2 (Nrf2), which regulates the expression of critical antioxidant proteins, was recently demonstrated to play a key role in cancer progression. Resistance radiotherapy is major obstacle treating oral squamous cell carcinoma (OSCC). However, little known about association between Nrf2 and radioresistance OSCC. Two OSCC lines (SAS HSC-2) their clinically relevant radioresistant (CRR) clones (SAS-R, HSC-2-R) were used. The effects downregulation on...
The highly malignant phenotype of oral squamous cell carcinoma (OSCC), including the presence nodal and distant metastasis, reduces patient survival. High-mobility group A protein 2 (HMGA2) is a non-histone chromatin factor that involved in advanced phenotypes poor prognosis several human cancers. However, its biological role OSCC remains to be elucidated. purpose this study was determine clinical significance HMGA2 potential OSCC. We first investigated expression pattern relevance 110...