A5031494774- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Neuroblastoma Research and Treatments
- T-cell and Retrovirus Studies
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
- Vector-Borne Animal Diseases
- Inflammatory Biomarkers in Disease Prognosis
- Animal Disease Management and Epidemiology
- Cancer, Lipids, and Metabolism
- Macrophage Migration Inhibitory Factor
- Cancer, Stress, Anesthesia, and Immune Response
- Endoplasmic Reticulum Stress and Disease
- Lung Cancer Treatments and Mutations
- Cancer Research and Treatments
- Cholesterol and Lipid Metabolism
- Glioma Diagnosis and Treatment
- Bone and Dental Protein Studies
- Neuroendocrine Tumor Research Advances
- Neuroinflammation and Neurodegeneration Mechanisms
- CAR-T cell therapy research
Kumamoto University
2016-2025
Kumamoto Health Science University
2025
Nagasaki University
2011
Kurume University
1990-2001
Kyushu University
1959-2000
Jikei University Kashiwa hospital
1998
Jikei University School of Medicine
1998
Saga Medical School Hospital
1994
Immune escape and tolerance in the tumor microenvironment are closely involved progression, caused by T‐cell exhaustion mediated inhibitory signaling of immune checkpoint molecules including programmed death‐1 ( PD ‐1), cytotoxic T‐lymphocyte associated protein 4, immunoglobulin mucin domaincontaining molecule‐3. In present study, we investigated expression ‐1 ligand 1 ‐L1) a lymphoma using paraffin‐embedded tissue samples, subsequently studied detailed mechanism upregulation ‐L1 on...
Recent studies have indicated the clinical significance of tumor‐associated macrophages ( TAM ) in several malignant tumors including breast cancer. Although recent focused on CD 68‐positive or 163‐positive cancer, no study has investigated 204‐positive We found that 204 expression was evaluated following stimulation with conditioned medium CM cancer cell lines. Paraffin sections 149 samples which were diagnosed as invasive ductal carcinoma immunohistochemically analyzed for 68, 163 and...
Osteopontin, also called secreted phosphoprotein 1 (SPP1), is a multifunctional phosphorylated glycoprotein. SPP1 expressed in tumor cells, and many studies demonstrated that high level of circulating correlated with poor prognosis various cancers. not only by cells but stromal such as macrophages. However, there have been no distinguishing the expression cancer tumor-associated macrophages (TAMs). Thus, this study, we tried to accurately evaluate status on TAMs separately patients non-small...
Clinical success of immune-checkpoint blockade (ICB) cancer immunotherapy is compromised by increased risk immune-related adverse events (irAEs). However, mechanistic action(s) immune responses underlying development irAE remain not fully explored. Here, we found that in tumor-bearing aged, but young, mice, antiprogrammed death receptor (PD)-1 therapy elicited irAE-like multiorgan dysfunctions with ectopic accumulation T and B cells damaged organs. In this preclinical model, the organ...
Glioblastoma (GBM) involves disruptions in the blood-brain barrier (BBB) and alterations immune microenvironment, including activation of glioma-associated macrophages (GAMs). Vascular endothelial growth factor inhibitors, commonly used recurrent GBM treatment, can influence these processes. This study investigates relationship between BBB disruption GAM activation, focusing on plasmalemma vesicle-associated protein (PLVAP), a marker disruption, α1-acid glycoprotein (AGP), an inflammatory...
The CD169+ macrophages in lymph nodes are implicated cytotoxic T lymphocyte (CTL) activation and associated with improved prognosis several malignancies. Here, we investigated the significance of oral squamous cell carcinoma (OSCC). Further, tested anti-tumor effects naringenin, which has been previously shown to activate macrophages, a murine OSCC model. Immunohistochemical analysis for CD169 CD8 was performed on node primary tumor specimens from 89 patients OSCC. We also evaluated...
Recent progress in anti-tumor immunotherapy has focused on the significance of tumor microenvironment progression and resistance to chemo/radio-therapy. Myeloid cells such as macrophages are predominant stromal components hematological malignancies. In present study, we investigated regulation programmed death-1 (PD-1) ligand expression primary central nervous system lymphoma (PCNSL) using PCNSL cell lines human monocyte-derived macrophages. TK line-derived soluble factors induced...
Abstract Ever since immune checkpoint inhibitors have been approved for anti-cancer therapy in several cancers, including triple-negative breast cancer, the significance of programmed death-1 ligand 1 (PD-L1) expression tumor microenvironment has a topic interest. In present study, we investigated detailed mechanisms PD-L1 overexpression on tumor-associated macrophages (TAMs) cancer. vitro culture studies using human monocyte-derived macrophages, lymphocytes, and cancer cell lines, was...
There are numerous macrophages and dendritic cells in lymph nodes (LNs). Recent studies have highlighted that sinus (SMs) LNs possess antigen-presenting capabilities related to anti-cancer immune responses. In this study, we assessed the distribution of SMs mesenteric removed during surgery for colorectal cancer. A marked reduction was noted elderly patients, particularly those over 80 years old. We observed a disappearance CD169-positive where were reduced. silico analysis publicly...
The tumor suppressor TP53 gene, the most frequently mutated gene in human cancers, produces product protein p53, which plays an essential role DNA damage. p53 mutations may contribute to tumorigenesis by loss of suppressive functions and malignancy cancer cells via gain-of-oncogenic functions. We previously reported that mutant proteins form aggregates cytoplasmic were associated with poor prognosis ovarian cancer. However, prognostic impact aggregation other tumors including lung squamous...
Abstract Recent advances in anti-cancer therapy have indicated the significance of tumour immune microenvironment progression and resistance to therapy. This study investigated primary colorectal cancer (CRC) tissues resected from 180 cases a single institute region highly endemic for human T-cell leukaemia virus type 1 (HTLV-1) carriers. Among those cases, 35 HTLV-1 carriers were identified. CRC patients who significantly older (mean age: 76.9 vs. 72.7 years, P = 0.0341), with lower...
Managing immune-related adverse events (irAEs) caused by cancer immunotherapy is essential for developing effective and safer therapies. However, cellular mechanism(s) underlying organ toxicity during anti-PD-(L)1 therapy remain unclear. Here, we investigated the effect of chronological aging on therapy-induced irAE-like lung toxicity, utilizing tumor-bearing aged mice. Anti-PD-(L)1 facilitated ectopic infiltration T B cells, antibody deposition in but not young Adoptive transfer...
Oral squamous cell carcinoma (OSCC) is one of the most common head and neck cancers, immunotherapy targeting programmed death 1 (PD-1) has become a treatment option for recurrent OSCC after surgery radiation therapy. However, few studies have identified definitive biomarkers predicting patient response to anti-PD1 therapy in OSCC. In present study, biopsy specimens were obtained from 23 patients with who subsequently treated Immunohistochemical examinations CD3, CD8, FOXP3, CD103, CD163,...
<title>Abstract</title> <italic><bold>Background:</bold></italic><italic> </italic>Immunotherapies targeting the programmed cell death-1 (PD-1) pathway have been adopted in lung adenocarcinoma (LUAD) treatment. Expression of death-ligand 1 (PD-L1) and PD-L2 is observed both cancer cells tumor-associated macrophages (TAMs). PD-L1/L2 expression TAMs thought to be induced by inflammatory cytokines, such as interferon (IFN)-g. Thyroid transcription factor-1 (TTF-1) a common diagnostic marker for...
Abstract Background CD169 + macrophages in lymph nodes (LNs) activate cytotoxic T lymphocytes (CTLs), which play a crucial role anticancer immunity, through antigen presentation and co-stimulation by CD169. Interferon alpha (IFNα) is capable of inducing the phenotype macrophages; however, its clinical applications have been hindered pharmacokinetic limitations—low LN distribution an inability to target macrophages. To overcome these issues, this study genetically fused mouse IFNα (mIFNα)...
Recent studies have indicated the significance of immune checkpoint molecules including programmed death-1 (PD-1), cytotoxic T-lymphocyte associated protein 4, and T-cell immunoglobulin mucin domain-containing molecule-3 for anti-tumor responses. We previously investigated PD-1 ligand 1/2 (PD-L1/2) expression in lymphoma cell lines, found that PD-L1/2 is expressed on adult leukemia/lymphoma (ATL-T) B-cell (SLVL) lines. In present study, we whether Stat3 inhibitor WP1066 abrogated Incubation...
Accumulating evidence suggests that high levels of Fusobacterium nucleatum in colorectal tumor tissues can be associated with poor prognosis patients cancer (CRC); however, data regarding distinct prognostic subgroups F. nucleatum–positive CRC remain limited. Herein, we demonstrate high-iron status was a worse nucleatum. Patients presenting elevated serum transferrin saturation exhibited preferential iron deposition macrophages the microenvironment. In addition, induced CCL8 expression via...
Cholesterol is an essential plasma membrane lipid for the maintenance of cellular homeostasis and cancer cell proliferation. Free cholesterol harmful to cells; therefore, excessive free must be quickly esterified by acetyl-coenzyme A:cholesterol acetyltransferase (ACAT) exported scavenger receptor class B member I (SR-BI) or ATP-binding cassette protein A1 from specific cells such as macrophage foam cells, which contain cholesteryl ester-derived vacuoles. Many vacuoles are present in...
The role of sinus macrophages (SMs) in anticancer immune responses has received considerable interest recent years, but the types molecules that are expressed human SMs have not yet been clarified detail. We therefore sought to identify dendritic cell (DC)- or macrophage-related lymph nodes (LNs). strongly positive for Iba-1, CD163, CD169, and CD209. CD169 (clone SP216) reacted with almost all SMs, mainly surface membrane, while HSn 7D2) a subpopulation cytoplasm, significant increase...
The prognosis of mediastinal neuroblastoma has been reported to be better than for other neuroblastomas. reason this is however not clear. Furthermore, a comparison between and the neuroblastomas rarely so far. In study, characteristics (84 cases) are investigated compared with those (440 cases). Regarding clinical factors, age distribution rate cases detected at mass screening were similar in both groups. According Evan's staging system, rates early stage (I, II) 62% 38% (p<0.001)....
Cholesterol uptake via LDL receptor (LDLR) is increased in some malignant tumors, and incorporated contribute to lipid droplet formation. Burkitt's lymphoma known have a large number of vacuoles the cytoplasm, however, intracellular are also seen high-grade lymphomas such as adult T-cell leukemia/lymphoma, diffuse B-cell primary central nervous system lymphoma. Recent studies shown that esterified cholesterol main component these expression metabolism-related molecules LDLR, acetyl-CoA...