A5030817537- CNS Lymphoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Lymphoma Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Axon Guidance and Neuronal Signaling
- Cancer Immunotherapy and Biomarkers
- 14-3-3 protein interactions
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Virus-based gene therapy research
- Brain Metastases and Treatment
- Hippo pathway signaling and YAP/TAZ
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Ubiquitin and proteasome pathways
- Cytokine Signaling Pathways and Interactions
- vaccines and immunoinformatics approaches
- Ferroptosis and cancer prognosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Head and Neck Surgical Oncology
- Meningioma and schwannoma management
- Neurosurgical Procedures and Complications
- Neurofibromatosis and Schwannoma Cases
- Neuroblastoma Research and Treatments
Kyoto Prefectural University of Medicine
2015-2025
Kindai University
2025
Target (United States)
2016-2019
Niigata University
1995-2016
Kurume University
2006-2013
Kumamoto University
2012
Chiba University
2012
Toyama Prefectural Central Hospital
2012
Yamaguchi University
2012
Brain (Germany)
2005
Polymorphonuclear leukocytes are essential for host defense to infectious diseases. CCAAT/enhancer binding protein epsilon (C/EBP epsilon) is preferentially expressed in granulocytes and lymphoid cells. Mice with a null mutation C/EBP develop normally fertile but fail generate functional neutrophils eosinophils. Opportunistic infections tissue destruction lead death by 3-5 months of age. Furthermore, end-stage mice myelodysplasia, characterized proliferation atypical that efface the bone...
Abstract Purpose: To investigate the safety and immunologic clinical responses of dendritic cell therapy for patients with recurrent malignant glioma. Experimental Design: Twenty-four glioma (6 grade 3 18 4 patients) were evaluated in a phase I/II study therapy. All resistant to standard maximum The patient's peripheral blood cells generated granulocyte macrophage colony-stimulating factor, plus interleukin or without OK-432, pulsed an autologous tumor lysate. Dendritic injected...
In this Phase I/II trial, the patient's peripheral blood dendritic cells were pulsed with an autologous tumour lysate of glioma. Seven patients glioblastoma and three anaplastic glioma, ranging in age from 20 to 69 years, participated study. The mean numbers vaccinations lysate-pulsed 3.7 times intradermally close a cervical lymph node, 3.2 intratumorally via Ommaya reservoir. percentage CD56-positive lymphocytes increased after immunisation. There two minor responses four no-change cases...
CCAAT/enhancer binding protein (C/EBP) ɛ is a recently cloned member of the C/EBP family transcription factors and expressed exclusively in cells hematopoietic origin. The human C/EBPɛ gene transcribed by two alternative promoters, Pα Pβ. A combination differential splicing use promoters generates four mRNA isoforms, 2.6 kb 1.3–1.5 size. These transcripts can encode three proteins calculated molecular mass 32.2 kDa, 27.8 14.3 kDa. Accordingly, Western blots with antibodies specific for...
Abstract The Eph receptor tyrosine kinases and their ephrin ligands form a unique cell-cell contact-mediated bidirectional signaling mechanism for regulating cell localization organization. High expression of receptors in wide variety human tumors indicates some roles tumor progression, which makes these proteins potential targets anticancer therapy. For this purpose, we did gene profiling 47 surgical specimens brain including 32 high-grade glioma using microarray technique. analysis,...
Abstract Purpose: The primary goal of this phase I study was to assess the safety and immunologic responses personalized peptide vaccination for patients with advanced malignant glioma. Experimental Design: Twenty-five glioma (8 grade 3 17 4 gliomas) were evaluated in a clinical vaccination. For vaccination, prevaccination peripheral blood mononuclear cells plasma provided examine cellular humoral 25 or 23 peptides HLA-A24+ HLA-A2+ patients, respectively; then, only reactive (maximum four)...
The present study aimed to identify genes associated with patient survival improve our understanding of the underlying biology gliomas. We investigated whether expression selected using random forests models could be used define glioma subgroups more objectively than standard pathology. RNA from 32 non-treated grade 4 gliomas were analyzed GeneChip Human Genome U133 Plus 2.0 Expression array (which contains approximately 47 000 genes). Twenty-five whose expressions strongly and consistently...
Primary central nervous system lymphoma (PCNSL) is one of the most aggressive malignant lymphomas with a median survival less than 20~40 months. Interest in signal transducer and activator transcription 3 (Stat3) has increased during past decade because Stat3 activation was found to contribute tumor progression by inducing angiogenesis, immunosuppression, metastasis. We previously demonstrated significant correlation between cells infiltrating anti-inflammatory (M2) macrophages. Here, we...
Common cancer treatments include radiation therapy, chemotherapy including molecular targeted drugs and anticancer drugs, surgical treatment. Recent studies have focused on investigating the mechanisms by which immune cells attack produce tolerance-suppressing cytokines, as well their potential application in immunotherapy. We conducted expression profiling of CD274 (PD-L1), GATA3, IFNG, IL12R, IL12RB2, IL4, PDCD1 (PD-1), PDCD1LG2 (PD-L2), TBX21 (T-bet) using data 158 glioblastoma multiforme...
Recent progress in anti-tumor immunotherapy has focused on the significance of tumor microenvironment progression and resistance to chemo/radio-therapy. Myeloid cells such as macrophages are predominant stromal components hematological malignancies. In present study, we investigated regulation programmed death-1 (PD-1) ligand expression primary central nervous system lymphoma (PCNSL) using PCNSL cell lines human monocyte-derived macrophages. TK line-derived soluble factors induced...
Multivariable analyses of global expression profiling are valid indicators the prognosis various diseases including brain cancers. To identify candidates for markers glioblastoma, we performed multivariable on status epithelial (EPI)–mesenchymal (MES) transition (EMT), glioma (GLI) stem cells (GSCs), molecular target therapy (MTT), and potential biomarkers (PGBs) using data clinical information from patients. Random forest survival Cox proportional hazards regression indicated significant...
Metabolome analysis is an emerging method that provides insight into intracellular and physiologic responses. Methotrexate (MTX) antifolate suppresses DNA syntheses by inhibiting dihydrofolate reductase. High-dose methotrexate treatment with deferred radiotherapy a standard protocol in primary central nervous system lymphoma (PCNSL) treatments. However, most cases come to relapse-acquired resistance, which the role of metabolic pathways largely unknown.Metabolome methotrexate-resistant...
Glioma is the most common type of primary brain tumor, accounting for 40% malignant tumors. Although a single gene may not be marker, an expression profiling and multivariate analyses cancer immunotherapy must estimate survival patients. In this study, we conducted immunotherapy-related genes, including those in Th1/2 helper T regulatory cells, stimulatory inhibitory checkpoint molecules associated with prediction 571 patients aggressive form gliomas, glioblastoma multiforme (GBM)....
To investigate immunological biomarkers to predict overall survival of advanced cancer patients under treatment with personalized peptide vaccination, correlations between and biomarkers, including cytotoxic T lymphocyte (CTL) immunoglobulin G (IgG) responses the vaccinated peptides, were investigated in 500 who received vaccination from October 2000 2008. The best clinical response was assessed for 436 patients, 43 (10%) had partial response, 144 (33%) stable disease 249 (57%) progressive,...