A5020422690- Peripheral Neuropathies and Disorders
- Myasthenia Gravis and Thymoma
- Dental Erosion and Treatment
- Dental materials and restorations
- Autoimmune Neurological Disorders and Treatments
- Hereditary Neurological Disorders
- Inflammatory Myopathies and Dermatomyositis
- Bone Tissue Engineering Materials
- Amyotrophic Lateral Sclerosis Research
- Muscle Physiology and Disorders
- Dental Research and COVID-19
- Multiple Sclerosis Research Studies
- Neurogenetic and Muscular Disorders Research
- Adipose Tissue and Metabolism
- Adrenal Hormones and Disorders
- Prion Diseases and Protein Misfolding
- Hematopoietic Stem Cell Transplantation
- Genetic Neurodegenerative Diseases
- Neurological diseases and metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Chemical Synthesis and Characterization
- Genetics and Neurodevelopmental Disorders
- Nanoplatforms for cancer theranostics
- Parkinson's Disease and Spinal Disorders
Tokushima University
2016-2025
Fukushima Medical University
2023
Kyoto Prefectural University of Medicine
2023
Chiba University
2023
Niigata University
2023
Kanazawa Medical University
2023
Morinaga Institute of Biological Science
2021-2023
University Medical Centre Mannheim
2022
Heidelberg University
2022
Tokushima University Hospital
2015-2022
Proteasome inhibitors are used to treat blood cancers such as multiple myeloma (MM) and mantle cell lymphoma. The efficacy of these drugs is frequently undermined by acquired resistance. One mechanism proteasome inhibitor resistance may involve the transcription factor Nuclear Factor, Erythroid 2 Like 1 (NFE2L1, also referred Nrf1), which responds insufficiency or pharmacological inhibition upregulating subunit gene expression. This "bounce-back" response achieved through a unique mechanism....
Trastuzumab deruxtecan (DS-8201) is an antibody–drug conjugate composed of a humanized monoclonal anti-HER2 antibody, cleavable tetrapeptide-based linker and potent topoisomerase I inhibitor. The drug's efficacy has been proven in HER2-positive breast gastric cancers. rate HER2 positivity biliary tract cancer (BTC) reported to be 5–20%, case reports clinical trials have suggested that inhibitors might active BTC. Here we describe the rationale design phase II HERB trial will evaluate safety...
The purpose of this study was to evaluate the role 10-methacryloyloxydecyl dihydrogen phosphate (MDP) contained in bonding resin a two-step self-etch adhesive system. An experimental (M0) containing MDP only primer, but not prepared. Clearfil SE Bond (MM) and M0 were compared terms microtensile bond strength dentin, ultimate tensile resin, dentin-resin interface morphology under SEM TEM. immediate µTBS values MM significantly decreased after thermal cycles while stable even 10,000 cycles. In...
<h3>Objective:</h3> As the number of elderly patients with myasthenia gravis (MG) has recently increased in Europe and USA, a retrospective survey Japanese MG was conducted single neurological centre over several decades. <h3>Methods:</h3> The study consisted 112 consecutive onset disease from 1971 to 2006 an area approximately 0.8 million inhabitants Japan. Patients were classified into three subgroups according age at onset: young (39 years old), middle aged (40–59 old) (60 old). trends...
We aimed to compare the cytokine and chemokine profiles of patients with multifocal motor neuropathy (MMN) those progressive muscular atrophy (PMA) amyotrophic lateral sclerosis (ALS) investigate immunologic differences in CNS.CSF from 12 MMN, 8 PMA, 26 sporadic ALS, 10 other noninflammatory neurologic disorders was analyzed for 27 cytokines chemokines using multiplex bead array assay. Cytokine titers 4 groups were compared, correlations between relevant clinical parameters evaluated.There...
This study evaluated the effect of Glutathione (GSH) bio-molecule on reduction enamel and dentin discoloration after application 38% silver diammine fluoride solution (SDF). One hundred twenty bovine teeth specimens were used. The divided into three groups: (1) SDF only (control); (2) followed by a potassium iodide (KI); (3) mixed with 20% GSH. Half exposed to light remainder kept in dark conditions (n = 10) Color changes measured using spectrophotometer at following time intervals: before...
The objective was to evaluate the effect of application silver diamine fluoride (SDF) on discoloration demineralized dentin over time. Dentin specimens were divided into four groups according time demineralization. A 38% SDF solution then applied surfaces. Half placed in light-proof boxes while remainder exposed light. Both maintained at 37˚C. Color change determined using a spectrophotometer different intervals. SEM/EDS analysis also undertaken. 13 h EDTA group showed highest values for...
Sporadic inclusion body myositis (sIBM) is the most prevalent acquired muscle disease in elderly. sIBM an intractable and progressive of unknown cause without effective treatment. The etiology still unknown; however, genetic factors, aging, lifestyles, environmental factors may be involved. purpose this study to elucidate cross-sectional profile patients affected by Japan.We surveyed patient data for 146 cases diagnosed at a number centers across Japan. We also issued questionnaire 67 direct...
Background and purpose Differential diagnosis of sporadic inclusion body myositis (s‐ IBM ) polymyositis ( PM )/dermatomyositis DM is difficult can affect proper disease management. Detection heterogeneous muscular involvement in s‐ by muscle sonography could be a unique diagnostic feature. Methods Sonography the lower leg forearm was performed patients with , / control subjects n = 11 each). Echo intensities EI s) adjacent muscles [medial head gastrocnemius versus soleus flexor digitorum...
Dentin bonding durability of recently introduced dental adhesives: Clearfil SE Bond 2 (SE2), Optibond XTR (XTR), and Scotchbond Universal (SBU) was investigated using Weibull analysis as well the micromorphological features acid-base resistant zone (ABRZ) created for adhesives. The procedures SBU were divided into three subgroups: self-etch (SBS), phosphoric acid (PA) etching on moist (SBM) or dry dentin (SBD). All groups thermocycled 0, 5,000 10,000 cycles followed by microtensile bond...
To elucidate current epidemiologic, clinical, and immunologic profiles treatments of stiff-person syndrome (SPS) in Japan.
<b>Objective:</b> The thymus has been implicated as a possible site of origin that triggers autoimmunity in myasthenia gravis (MG). Although several groups have suggested the decrease number regulatory T (Treg) cells contributes to onset MG, exact role Treg MG remains unclear. To address this point, we examined and distribution large patients with MG. <b>Methods:</b> Immunohistofluorescence analysis Foxp3 along CD4 CD8 was performed thymic sections (+) (n = 24) (−) 27). Circulating...
Abstract Tuft cells are chemosensory epithelial in the respiratory tract and several other organs. Recent studies revealed tuft cell-like gene expression signatures some pulmonary adenocarcinomas, squamous cell carcinomas (SQCC), small (SCLC), large neuroendocrine (LCNEC). Identification of their similarities could inform shared druggable vulnerabilities. Clinicopathological features (tcl) subsets various lung cancer histotypes were studied two independent tumor cohorts using...
A UV-cleavable supramolecular cross-linker was designed to effectively control the mechanical strength of photocurable resin plastics. The monomer-soluble polyrotaxane (PRX) synthesized by introducing a hydrophobic n-butyl group and cross-linkable methacrylate in α-cyclodextrin threading polyethylene glycol containing end groups. PRX completely dissolved 2-hydroxyethytl (HEMA) camphorquinone, representative components. dumbbell-like stiff plastic prepared irradiating mixture with 450 nm blue...
Background and purpose Many epidemiological studies of Guillain−Barré syndrome ( GBS ) Fisher FS have been conducted in Europe America. In contrast, are rare Asia where the subtypes differ from those Western countries. This study was undertaken to clarify incidence a local area Japan as well their seasonal trends. Method Seventy‐one 37 patients were recorded 2006 2015 an approximately 1.5 million inhabitants Japan. The incidence, trends clinical features examined. Results rate 0.42 cases per...
The continuous increase in the number of patients presenting with late-onset myasthenia gravis (LOMG) underscores need for a better understanding clinical course and establishment an optimal therapeutic strategy. We aimed to clarify factors associated outcomes LOMG.We retrospectively reviewed profiles 40 early-onset MG (EOMG) (onset age: 49 years or younger), 30 non-elderly LOMG 50-64 years), 28 elderly 65 older) compared subgroups according onset age thymus status. evaluated parameters were...
The purpose of this study was to evaluate the effects two different concentrations silver diammine fluoride (SDF) on dentin bonding performance. Human mid-coronal treated with either distilled water (control), 3.8%SDF or 38%SDF for 3 min. A two-step self-etch adhesive and resin composite were applied according manufacturer's instructions. After thermocycling (TC) at 0, 5,000 10,000 cycles, microtensile bond strength (µTBS) testing morphological assessment resin-dentin interface performed. At...