A5103279102- Parathyroid Disorders and Treatments
- Phytoestrogen effects and research
- Magnesium in Health and Disease
- Bone health and osteoporosis research
- Bone health and treatments
- Bone Metabolism and Diseases
- Food composition and properties
- Folate and B Vitamins Research
- Diet, Metabolism, and Disease
- Microbial Metabolites in Food Biotechnology
- Cancer Risks and Factors
- Iron Metabolism and Disorders
- Fatty Acid Research and Health
- Estrogen and related hormone effects
- Animal Nutrition and Physiology
- Adipose Tissue and Metabolism
- Genetic Syndromes and Imprinting
- Tea Polyphenols and Effects
- Genomics, phytochemicals, and oxidative stress
- Metabolism, Diabetes, and Cancer
- Phytochemicals and Antioxidant Activities
- Food Quality and Safety Studies
- Kidney Stones and Urolithiasis Treatments
- Genomic variations and chromosomal abnormalities
- Genetic and Kidney Cyst Diseases
Tokyo University of Agriculture
2015-2025
Shinshu University
2018
The University of Tokyo
2013-2017
JFE Holdings (Japan)
2012
Niigata University of Pharmacy and Medical and Life Sciences
2010
National Institute of Infectious Diseases
2007
University of Helsinki
2000-2007
Nagoya University
2006
Chinese University of Hong Kong
2006
Teikyo University
1980-2002
Biological effects of dietary isoflavones, such as daidzein and genistein are interest in preventive medicine. We estimated the intake isoflavones from records compared values with plasma concentrations urinary excretions Japanese middleaged women. The was 64.6 111.6μ mol/day/capita (16.4 30.1 mg/day/capita), respectively. mostly attributable to tofu, natto miso. median concentration 72.46 206.09 nmol/L, excretion 20.54μ mol/day for daidzein, 10.79 genistein, 15.74 equol 1.64...
Medicinal plants constitute an important source of potential therapeutic agents for diabetes. In the present study, we investigated effects Moringa oleifera (MO) Lam, Moringacea, on glucose tolerance in Wistar rats and Goto-Kakizaki (GK) rats, modeled type 2 Major polyphenols MO powder were quercetin glucosides, rutin, kaempferol glycosides chlorogenic acids by HPLC analysis. As results test, significantly decreased blood at 20, 30, 45and 60 min GK 10, 30 45 (p<0.05) compared to both...
Citrus bioflavonoids may offer some protection against the early stage of diabetes mellitus and development complications. We investigated effect hesperidin on blood glucose levels, hepatic glucose-regulating enzyme activities, serum insulin adiponectin lipid parameters bone loss in streptozotocin (STZ)-induced marginal type 1 diabetic rats. Weanling male rats were randomly assigned to experimental 3 groups: a control (C) group, STZ induced (S) fed their respective diets for 4 weeks....
In Brief Objective: Equol is more biologically active than its precursor daidzein, which the principal isoflavone found in soybean. There are interindividual differences ability to produce equol; these may lead effects of intervention on human health. This study aimed investigate whether soy isoflavones bone and fat mass related an individual's equol status. Design: We performed a 1-year double-blind, randomized trial compare (75 mg conjugates/day) with those placebo mineral density, mass,...
We investigated the hypoglycemic and hypolipidemic effects of two hesperertin glycosides, namely, hesperidin cyclodextrin (CD)-clathrated hesperetin, in Goto-Kakizaki (GK) weanling rats with type 2 diabetes. demonstrated that CD-hesperetin normalized glucose metabolism by altering activities glucose-regulating enzymes reducing levels lipids serum liver GK rats. These glycosides were partly produced expression genes encoding peroxisome proliferator-activated receptors,...
AimsAlthough dietary saturated fatty acids (SFA) are considered atherogenic, associations between SFAs intake and stroke coronary heart disease still debated. We sought to test the hypothesis that SFA is associated inversely with risk of its subtypes positively among Japanese, whose average lower than Westerners.
Abstract The effects of the dietary Ca and P ratio, independent any vitamin D effects, on bone mineralization turnover was examined in 60 VDRKO mice fed different Ca/P ratio diets. High promoted with adequate intestinal transports mice. Introduction: To clarify calcium (Ca) phosphorus (P) (Ca/P ratio) null-vitamin signal condition, receptor knockout (VDRKO) were given diets containing ratios. Materials Methods: Five groups 4-week-old mice, 10 animals each, for 4 weeks. Group 1 wild-type...
Abstract Little is known about the direct effect of broccoli sprouts on human health. So we investigated induction various biochemical oxidative stress markers. Twelve healthy subjects (6 males and 6 females) consumed fresh (100 g/day) for 1 week a phase study. Before after treatment, examination was conducted natural killer cell activity, plasma amino acids, PCOOH (phosphatidylcholine hydroperoxide), serum coenzyme Q 10 , urinary 8‐isoprostane, 8‐OHdG (8‐hydroxydeoxyguanosine) were...
Lignans constitute a group of phytochemicals widely distributed in the human diet. Once ingested, most dietary lignans are metabolized by gut microflora to enterolactone and enterodiol, also known as enterolignans. Together with isoflavones coumestrol, enterolignans have been traditionally classified phytoestrogens, plant-derived compounds that exhibit estrogen-like activity. In addition higher intake vegetables, many studies suggested presence phytoestrogens Japanese diet is one factors...
Abstract Time‐resolved fluoroimmunoassays (TR‐FIA), with europium labeled phytoestrogens as tracers, were developed for the quantitative measurement of genistein, daidzein and enterolactone in plasma urine purpose screening large populations studies on possible correlation between values biological fluids risk western diseases. The mean three determined by TR‐FIA similar to those obtained gas chromatography‐mass spectrometry (GC‐MS). urinary excretion levels total individual higher than...
We investigated the effects of dietary iron deficiency on bone metabolism by measuring markers turnover in rats. Twelve 3-week-old male Wistar-strain rats were fed a control diet or an iron-deficient for 4 weeks. Dietary decreased hemoglobin concentration and increased heart weight. Serum osteocalcin concentration, mineral content, density, mechanical strength femur significantly lower group than group. These results suggested that affected bone, which might have been due to decrease formation