A5034229510- Intracranial Aneurysms: Treatment and Complications
- Optical Imaging and Spectroscopy Techniques
- Cerebrovascular and Carotid Artery Diseases
- Advanced MRI Techniques and Applications
- Acute Ischemic Stroke Management
- Moyamoya disease diagnosis and treatment
- Glioma Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Non-Invasive Vital Sign Monitoring
- Photoacoustic and Ultrasonic Imaging
- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced Neuroimaging Techniques and Applications
- Pituitary Gland Disorders and Treatments
- Heat shock proteins research
- Medical Imaging Techniques and Applications
- Infrared Thermography in Medicine
- Blood Pressure and Hypertension Studies
- Thermoregulation and physiological responses
- Biochemical effects in animals
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Cerebrospinal fluid and hydrocephalus
- Cervical and Thoracic Myelopathy
Yamagata University
2014-2024
National Cerebral and Cardiovascular Center
2013-2024
Marquette General Hospital
2018
King's College London
2017
Yamagata University Hospital
2003-2014
University of Hyogo
2007
Tohoku University
2006
Neurological Surgery
2002-2003
University of California, San Francisco
2002-2003
San Francisco VA Medical Center
2000
Increased expression of heat shock protein 70 (HSP70) in the brain has been extensively documented association with a variety insults, including ischemia, and is suggested to play role cell survival recovery after ischemic injury. To more directly assess protective HSP70 during damage, we used transgenic mice overexpressing rat (HSP70tg mice). In contrast wild-type (wt) littermates, high levels messenger RNA were detected brains HSP70tg under normal conditions, immunohistochemical analysis...
AimsAlthough dietary saturated fatty acids (SFA) are considered atherogenic, associations between SFAs intake and stroke coronary heart disease still debated. We sought to test the hypothesis that SFA is associated inversely with risk of its subtypes positively among Japanese, whose average lower than Westerners.
Background: In the adult mammalian brain, it is considered that neurogenesis persists in limited regions such as hippocampal dentate gyrus (DG) and subventricular zone (SVZ) of lateral ventricle. On other hand, cortex after cerebral ischemia its role post-stroke recovery have not been clarified yet. this study, we investigated spatiotemporal profile neural progenitors SVZ DG rats subjected to transient focal ischemia. Materials methods: Male Sprague–Dawley (270–300 g) were 60 minute middle...
Blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) are risk factors for coronary artery disease (CAD) ischemic stroke. However, the hazards of their coexistence not fully understood in Asian populations. We investigated whether relationship between BP cardiovascular (CVD) outcomes modified by LDL-C level a Japanese population. Individuals aged 30–79 years (n = 5,151) were classified into 6 groups according to levels (<140 ≥140mg/dL or lipid medication) (optimal BP,...
The purpose of this study was to correlate the cerebral protein synthesis (CPS) reductions in ischemic core and penumbra with metabolic stress response indicated by heat shock 70 (HSP70) synthesis.Rats were subjected 90 minutes temporary focal ischemia produced occlusion middle artery, using endovascular suture model. Regional CPS qualitatively evaluated, [(35)S]methionine autoradiography, after reperfusion for 2 72 hours. observed changes correlated HSP70 immunoreactivity, as assessed same...
During surgical treatment for cerebrovascular diseases, cortical hemodynamics are often controlled by bypass graft surgery, temporary occlusion of arteries, and removal veins. Since the brain is vulnerable to hypoxemia ischemia, interruption cerebral blood flow reduces oxygen supply tissues induces irreversible damage cells tissues. Monitoring alteration cellular structure during neurosurgery thus crucial. Sequential recordings red-green-blue (RGB) images in vivo exposed rat brains were made...
The authors investigated the relationship between time course of apparent diffusion coefficient (ADC) changes and stress protein induction, ischemic neuroglial damage, cerebral synthesis (CPS) after temporary focal ischemia in rats.In Group I, ADC were measured on magnetic resonance (MR) images obtained during second half a 1-hour middle artery (MCA) occlusion, reperfusion, 23 hours reperfusion rats. Immunohistochemical studies for heat shock (hsp) 70, glial fibrillary acidic (GFAP),...
Neural stem cells (NSCs) have been demonstrated in the subventricular zone (SVZ) of lateral ventricle and subgranular hippocampal dentate gyrus (DG). Although aging rats manifest a decrease NSCs, exposed to stress (for example, ischemia, epilepsy, radiation, trauma) show an increase these cells. In transgenic mice, overexpression human copper/zinc superoxide dismutase (SOD1), endogenous antioxidant, has reported be protective enzyme against transient focal cerebral ischemia. The authors...
Additional resection beyond contrast enhanced lesion on MRI is recently considered to prolong survival in glioblastoma. Prediction of future recurrent site the peritumoral preoperative could be useful for surgical planning. The objective this study was determine if ADC value associated with recurrence patients We retrospectively analyzed 21 primary GBM. were before and after operation at recurrence. region interests (ROIs) set cover almost FLAIR high-signal surrounding lesion. determined...
Increased expression of heat shock protein 70 (HSP70) in the brain has been extensively documented association with a variety insults, including ischemia, and is suggested to play role cell survival recovery after ischemic injury. To more directly assess protective HSP70 during damage, we used transgenic mice overexpressing rat (HSP70tg mice). In contrast wild-type (wt) littermates, high levels messenger RNA were detected brains HSP70tg under normal conditions, immunohistochemical analysis...
We propose a method to perform simultaneous measurements of percutaneous arterial oxygen saturation ( SpO 2 ), tissue StO pulse rate PR and respiratory RR ) in real-time, using digital red–green–blue (RGB) camera. Concentrations oxygenated hemoglobin C HbO deoxygenated HbR total HbT were estimated from videos the human face based on tissue-like light transport model skin. The photoplethysmogram (PPG) signals are extracted temporal fluctuations , finite impulse response (FIR) filter (low high...
Background Arterial transit time correction by data acquisition with multiple post-labeling delays (PLDs) or relatively long PLDs is expected to obtain more accurate imaging in cases of the cerebrovascular steno-occlusive disease. However, there have so far been no reports describing significance arterial spin labeling (ASL) images at short regarding evaluation cerebral circulation ischemic Purpose To clarify role short-PLD ASL Material and Methods Fifty-three patients disease were included...
A 44-year-old female presented with left occipital arteriovenous malformation (AVM) manifesting as sudden onset of severe headache. Magnetic resonance (MR) imaging and conventional angiography showed the AVM hemorrhage. Intraoperative MR (iMR imaging) intraoperative time-resolved contrast-kinetics (iTRICKS) at 1.5 T revealed complete removal nidus without catheter angiography. Conventional is commonly used in preoperative examination AVMs, for documentation surgical outcome, but...
The problem with treatments against skull lesions of Langerhans cell histiocytosis (LCH) is that invasions often reach the bones and dura mater, making it difficult to accurately comprehend range thereof prior surgery. We herein report (11)C-methionine positron emission tomography (PET) (Met-PET) carried out surgery was useful in comprehending spreading lesion.A 20-year-old female presented swelling dull pain on left side head. A slightly heterogeneously reinforced tumor observed inside bone...
We report a case of unruptured “true posterior communicating artery” (Pcom) aneurysm associated with ruptured internal carotid-posterior artery (IC-PC) in 72-year-old woman, treated successfully by direct surgery. Left carotid angiography and three-dimensional CT revealed an IC-PC 8 mm maximum diameter protruding inferolaterally, small bulge on the Pcom side which was regarded as part aneurysm. Intraoperative inspection that prominence initially thought to be true forming kissing pair The 2...