ABSTRACT We designed an "equator ring," a flexible silicone rod with groove on its inner surface, to maintain the circular contour of capsular bag equator after cataract removal. After extraction, ring is inserted in through 5.0-mm capsulorhexis or 4.5-mm linear "dumbbell" opening. Then conventional posterior chamber intraocular lens (PC-IOL) inserted, IOL loops groove. The not only allows complete maintenance for most PC-IOLs, but also may prevent invasion metamorphosed epithelial cells...

Abstract Purpose: Survivin, a member of the inhibitor apoptosis protein family, is an attractive target for cancer therapy. We have now investigated effect YM155, small-molecule survivin expression, on sensitivity human non–small cell lung (NSCLC) lines to γ-radiation. Experimental Design: The radiosensitizing YM155 was evaluated basis death, clonogenic survival, and progression tumor xenografts. Radiation-induced DNA damage histone H2AX phosphorylation foci formation. Results: induced...

The expression and activity of the epidermal growth factor receptor (EGFR) are determinants radiosensitivity in several tumour types, including non-small cell lung cancer (NSCLC). However, little is known whether genetic alterations EGFR NSCLC cells affect therapeutic response to monoclonal antibodies (mAbs) combination with radiation. We examined effects nimotuzumab, a humanised mAb EGFR, ionising radiation on human lines differing status. Flow cytometry revealed that H292 Ma-1 expressed...

A silica-based optical waveguide on a silicon substrate with terrace regions is proposed. Because the equipped low-loss and an bench at same time, it applicable to hybrid integration platform.

The incidence of gallstones is higher in people who have undergone gastrectomy than the general population, but cause this unknown.Between January 1992 and 2003, 749 patients underwent ultrasonography gallbladder after for gastric cancer. A total 2327 examinations were carried out. was compared subgroups classified according to type reconstruction, extent gastrectomy, whether duodenum excluded lymph node dissection.The significantly with partial (27.9 versus 7.8 per cent at 5 years; P <...

Sorafenib is a multikinase inhibitor whose targets include B-RAF and C-RAF, both of which function in the extracellular signal-regulated kinase (ERK) signaling pathway but also have distinct downstream targets. The relative effects sorafenib on C-RAF tumor cells remain unclear, however. We now examined as well or depletion by RNA interference cell growth ERK non-small lung cancer (NSCLC) lines with without KRAS mutations. inhibited phosphorylation wild-type not those mutant KRAS. Despite...

Abstract Most non–small cell lung cancer (NSCLC) tumors with an activating mutation of the epidermal growth factor receptor (EGFR) are initially responsive to EGFR tyrosine kinase inhibitors (TKI) such as gefitinib but ultimately develop resistance these drugs. Hepatocyte (HGF) induces EGFR-TKI in NSCLC cells a mutation. We investigated strategies overcome induced by HGF. Human (HCC827 cells) were engineered stably express HGF (HCC827-HGF cells). HCC827-HGF secreted large amounts and...

We aimed to investigate the nationwide incidence, treatment details and outcomes of patients with endogenous hyperinsulinemic hypoglycemia (EHH), including those transient/persistent congenital hyperinsulinism (CHI), insulinoma, non-insulinoma pancreatogenous syndrome insulin autoimmune (Hirata's disease) in Japan.

The authors have fabricated an optical WDM module with a simple configuration using PLC platform together spot-size converted LD (SS-LD) and waveguide PD (WG-PD). Since the can be formed simply by flip-chip bonding of SS-LD WG-PD, this reduces number components, thus helps achieve cost reduction.

Abstract Somatic mutations in the epidermal growth factor receptor (EGFR) gene are associated with therapeutic response to EGFR tyrosine kinase inhibitors (TKI) patients advanced non-small cell lung cancer (NSCLC). The rate these drugs remains low, however, NSCLC wild-type alleles. Combination therapies EGFR-TKIs and cytotoxic agents considered a option for expressing EGFR. We investigated antiproliferative effect of combination oral fluorouracil S-1 EGFR-TKI gefitinib cells differing...

Survivin, a member of the inhibitor apoptosis protein family, is an attractive target for cancer therapy. We have now investigated effects combination YM155, novel small-molecule survivin expression, and platinum compounds (cisplatin carboplatin) on human non-small cell lung (NSCLC) lines.The anti-cancer efficacy YM155 in with was evaluated basis death progression tumour xenografts. Platinum compound-induced DNA damage by immunofluorescence analysis histone gamma-H2AX.Immunofluorescence...

Therapeutic strategies that target c-Src hold promise for a wide variety of cancers. We have now investigated both the effects dasatinib, which inhibits activity and several other kinases, on cell growth as well mechanism dasatinib resistance in human gastric cancer lines. Immunoblot analysis revealed activation at various levels most lines examined. Dasatinib inhibited phosphorylation extracellular signal-regulated kinase (ERK) induced G(1) arrest, by flow cytometry, subset responsive In...

Abstract Purpose: Therapeutic strategies that target the insulin-like growth factor I receptor (IGF-1R) hold promise for a wide variety of cancers. We have now investigated effect CP-751,871, fully human monoclonal antibody specific IGF-IR, on sensitivity non–small cell lung cancer (NSCLC) lines to radiation. Experimental Design: The radiosensitizing CP-751,871 was evaluated basis death, clonogenic survival, and progression tumor xenografts. Radiation-induced damage by immunofluorescence...

The efficacy of epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitors such as gefitinib and erlotinib in non‐small cell lung cancer (NSCLC) is often limited by the emergence drug resistance conferred either a secondary T790M mutation EGFR or acquired amplification MET gene. We now show that extent activation tyrosine Src markedly increased gefitinib‐resistant NSCLC (HCC827 GR) cells with compared gefitinib‐sensitive parental (HCC827) cells. In contrast, did not differ between...

Tissue factor pathway inhibitor 2 (TFPI2) is a novel serum biomarker that discriminates ovarian clear cell carcinoma (CCC) from borderline tumors (BOTs) and non-clear epithelial cancers (EOCs). Here, we examined the performance of TFPI2 for preoperative diagnosis CCC.Serum samples were obtained preoperatively patients with masses, who needed surgical treatment at five hospitals in Japan. The diagnostic powers cancer antigen 125 (CA125) levels to discriminate CCC BOTs, other EOCs, benign...

Abstract Purpose: Most non–small cell lung cancer (NSCLC) tumors with activating mutations in the epidermal growth factor receptor (EGFR) are initially responsive to EGFR tyrosine kinase inhibitors (EGFR-TKI) such as gefitinib and erlotinib, but they almost invariably develop resistance these drugs. A secondary mutation (T790M) amplification of MET proto-oncogene have been identified mechanisms acquired EGFR-TKIs. We now investigated whether addition oral fluoropyrimidine derivative S-1...

The gold standard for breast cancer treatment is surgery, but many women may desire to avoid surgery if possible. purpose of this study was evaluate whether could be cured with modern sophisticated radiation techniques good cosmetic outcome. We have treated 18 patients operable by conventional whole-breast irradiation followed stereotactic body radiotherapy (primary tumor only) or intensity-modulated (tumor plus axillary nodes) boost. planned doses were 50 Gy in 25 fractions, 25.5 3 and 20 8...

Abstract Aim Tissue factor pathway inhibitor 2 (TFPI2) is a preoperative biomarker that was developed to discriminate ovarian benign tumors from cancer and covered by health insurance in Japan. The purpose of this study evaluate how the TFPI2 changes after treatment. Methods Serum levels (cut off 191 pg/mL) CA125 35 U/mL) before primary debulking surgery patients with malignant were evaluated among recurrent nonrecurrent cases, respectively. Results A total 46 cases analyzed, including 11...

Transcription factor hepatocyte nuclear 1-beta (HNF-1β) enhances checkpoint kinase 1 (Chk1) activation and promotes G2/M cell cycle progression in ovarian clear carcinoma (CCC) following exposure to diverse genotoxic agents including bleomycin. However, the underlying mechanism leading of HNF-1β still remains largely unknown. To clarify effects on checkpoints, human CCC lines were transfected with siRNAs targeting HNF-1β, Claspin, USP28, or a control vector. Ubiquitination stabilization...

Abstract We aimed to retrospectively analyze the risk factors of a continuous dienogest (DNG) therapy for serious unpredictable bleeding in patients with symptomatic adenomyosis. This is retrospective study based on data extracted from medical records 84 women treated 2 mg DNG orally each day between 2008 and 2017. 47 subjects were excluded original analyses due an inadequate subcategorization into subtype I II lack hemoglobin levels. The influence various independent variables was assessed....