A5066841617- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Statistical Methods in Clinical Trials
- Lung Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Treatments and Studies
- Breast Cancer Treatment Studies
- Liver Disease Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Cancer-related gene regulation
- Metastasis and carcinoma case studies
- Cancer Treatment and Pharmacology
- Esophageal and GI Pathology
- Prostate Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Prostate Cancer Treatment and Research
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Advanced Causal Inference Techniques
- Epigenetics and DNA Methylation
- Gastrointestinal Tumor Research and Treatment
- Kidney Stones and Urolithiasis Treatments
- RNA modifications and cancer
- Neutropenia and Cancer Infections
- Meta-analysis and systematic reviews
Juntendo University
2023-2025
Juntendo University Hospital
2024-2025
Yokohama City University
2015-2024
Chiba University Hospital
2024
The University of Tokyo
2006-2024
Tokai University
2024
Juntendo University Urayasu Hospital
2024
International University of Health and Welfare
2024
Assistance Publique – Hôpitaux de Paris
2024
Memorial Hospital
2024
Abstract The number of deaths from colorectal cancer in Japan continues to increase. Colorectal exceeded 50,000 2016. In the 2019 edition, revision all aspects treatments was performed, with corrections and additions made based on knowledge acquired since 2016 version (drug therapy) 2014 (other treatments). Japanese Society for Cancer Colon Rectum guidelines treatment (JSCCR 2019) have been prepared show standard strategies cancer, eliminate disparities among institutions terms treatment,...
Background Nonalcoholic steatohepatitis (NASH) is diagnosed with histopathologic testing, but noninvasive surrogate markers are desirable for screening patients who at high risk of NASH. Purpose To investigate the diagnostic performance dispersion slope, attenuation coefficient, and shear-wave speed measurements obtained using two-dimensional (2D) elastography (SWE) in assessing inflammation, steatosis, fibrosis diagnosis NASH suspected having nonalcoholic fatty liver disease (NAFLD)....
Abstract BACKGROUND Sustained chronic inflammation in the prostate promotes carcinogenesis. Since an elevated level of prostate‐specific antigen (PSA) per se reflects presence prostate, intervention to improve PSA value might potentially have beneficial effects for prevention development cancer. Isoflavones and curcumin anti‐inflammatory anti‐oxidant properties. We examined biological soy isoflavones on LNCaP cells. After that, we conducted a clinical trial men who received biopsies, but...
To verify whether body mass index (BMI) classification proposed by the Institute of Medicine (IOM) is valid in Japanese women.A study was conducted 97,157 women with singleton pregnancies registered Japan Society Obstetrics and Gynecology (JSOG) Successive Pregnancy Birth Registry System between January 2013 December 2013, to examine pregnancy outcomes four groups stratified pre-pregnancy BMI category according 2009 criteria recommended (IOM). The comprised 17,724 underweight <18.5, 69,126...
Abstract Background Total gastrectomy for gastric cancer is associated with excessive weight loss and decreased calorie intake. Nutritional support using eicosapentaenoic acid modulates immune function limits catabolism in patients advanced cancer, but its impact the perioperative period unclear. Methods This was a randomized phase III clinical trial of addition acid-rich nutrition to standard diet having total cancer. Patients were either or oral supplementation an (ProSure®), comprising...
The Recurrence Score test is validated to predict benefit of adjuvant chemotherapy. TransNEOS, a translational study New Primary Endocrine-therapy Origination Study (NEOS), evaluated whether results can clinical response neoadjuvant letrozole.NEOS phase 3 trial hormonal therapy ± chemotherapy for postmenopausal patients with ER+, HER2-negative, clinically node-negative breast cancer, after six months letrozole and surgery. TransNEOS had tumors ≥ 2 cm archived core-biopsy samples taken before...
To investigate the relationship between long interspersed nucleotide element-1 (L1/LINE-1) methylation level and disease-free survival cancer-specific in patients with esophageal squamous cell carcinoma (ESCC).Cancer cells exhibit 2 types of deoxyribonucleic acid (DNA) alterations: global DNA hypomethylation site-specific CpG island promoter hypermethylation. Global plays a role genomic instability carcinogenesis. LINE-1 repetitive element is good indicator level. Although attracting...
To develop and internally validate a preoperative nomogram for predicting stone-free status (SF) after flexible ureteroscopy (fURS) renal stones, as there is need to predict the outcome of fURS treatment stone disease.We retrospectively analysed 310 procedures removal performed between December 2009 April 2013. Final was determined by computed tomography 3 months last session. Assessed factors included volume number, age, sex, presence hydronephrosis lower pole calculi, ureteric stent...
// Takashi Kawahara 1, 2, * , Sachi Fukui Kentaro Sakamaki 3 Yusuke Ito 1 Hiroki Naohito Kobayashi Koji Izumi Yumiko Yokomizo Yasuhide Miyoshi 2 Kazuhide Makiyama Noboru Nakaigawa Takeharu Yamanaka Masahiro Yao Hiroshi Miyamoto 4 Hiroji Uemura Department of Urology, Yokohama City University, Graduate School Medicine, Yokohama, Japan Departments Urology and Renal Transportation, University Medical Center, Biostatistics, Pathology Johns Hopkins Baltimore, USA These authors have contributed...
Excessively short and long sleep durations are associated with type 2 diabetes, but there is limited information about the association between quality diabetes. Accordingly, present study was performed to investigate this relationship.The subjects were 3249 patients diabetes aged 20 years or older. Sleep assessed by using Pittsburgh Quality Index (PSQI). A higher global PSQI score indicates worse quality, a >5 differentiates poor sleepers from good sleepers.The mean 5.94 ± 3.33, 47.6% of had...
Abstract Purpose: Global DNA hypomethylation plays a crucial role in genomic instability and carcinogenesis. methylation of the long interspersed nucleotide element-1, L1 (LINE-1) repetitive element is good indicator global level, attracting interest as useful marker for predicting cancer prognosis. Our previous study using more than 200 esophageal squamous cell carcinoma (ESCC) specimens demonstrated significant relationship between LINE-1 poor However, mechanism by which affects aggressive...
Purpose We evaluated the noninferiority of dexamethasone (DEX) on day 1, with sparing days 2 and 3, combined neurokinin-1 receptor antagonist (NK 1 -RA) palonosetron (Palo) compared 3-day use DEX in highly-emetogenic chemotherapy (HEC). Patients Methods who were scheduled to receive HEC (cisplatin ≥ 50 mg/m or anthracycline plus cyclophosphamide) randomly assigned either 3 (Arm D3) placebo D1) NK -RA Palo. The primary end point was complete response (CR), defined as no emesis rescue...
Objective. Ultrasonography (US) is a simple, inexpensive and minimally invasive method. We evaluated the vascularity of small intestinal lesions in Crohn's disease using color Doppler US (CD-US) retrospectively compared them with endoscopic surgical macroscopic findings. Material methods. In order to compare CD-US findings, 108 patients who underwent examination terminal ileum by both colonoscopy were included study. Vascularity was semiquantitative method, Limberg score. analyzed...
<h3>BACKGROUND AND PURPOSE:</h3> Dual-energy CT can distinguish iodine-enhanced tumors from nonossified cartilage and has been investigated for evaluating invasion in patients with laryngeal hypopharyngeal squamous cell carcinomas. In this study, we compared the diagnostic accuracy of MR imaging a combination weighted-average iodine overlay dual-energy images detecting by carcinomas, particular thyroid invasion. <h3>MATERIALS METHODS:</h3> Fifty-five consecutive who underwent 3T 128-slice...
There is no reliable biomarker for predicting the prognosis of patients who undergo radical cystectomy bladder cancer. Recent studies have shown that neutrophil-to-lymphocyte ratio (NLR) could function as a useful prognostic factor in several types malignancies. This study aimed to assess usefulness NLR A total 74 underwent our institutions from 1999 2014 were analyzed. The was calculated using patients' neutrophil and lymphocyte counts before cystectomy. An immunohistochemical analysis also...
Abstract Background COVID-19 has rapidly evolved to become a global pandemic due largely the transmission of its causative virus through asymptomatic carriers. Detection SARS-CoV-2 in people is an urgent priority for prevention and containment disease outbreaks communities. However, few data are available persons regarding accuracy PCR testing. Additionally, although self-collected saliva significant logistical advantages mass screening, utility as alternative specimen yet be determined....
Despite the diversity of thermal ablations, such as radiofrequency ablation (RFA) and microwave (MWA), non-thermal ablation, irreversible electroporation (IRE) cross-comparisons multiple ablative modalities for hepatocellular carcinoma (HCC) treatment remain scarce. Thus, we investigated therapeutic outcomes different three in early stage HCC.A total 322 consecutive patients with 366 HCCs (mean tumor size ± standard deviation: 1.7 0.9 cm) who underwent RFA (n = 216, 59.0%), MWA 91, 28.3%),...
Background Attenuation coefficient (AC) and shear-wave speed (SWS) are established US markers for assessing patients with metabolic dysfunction-associated steatotic liver disease (MASLD), while dispersion slope (DS) is not. Purpose To assess the relationship between multiparametric imaging DS, AC, SWS histopathologic necroinflammation in MASLD. Materials Methods This international multicenter prospective study enrolled consecutive biopsy-proven MASLD June 2019 March 2023. Before biopsy, all...