A5031310389- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Ultrasound and Hyperthermia Applications
- Liver Disease and Transplantation
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Ultrasound in Clinical Applications
- Ovarian function and disorders
- Breast Lesions and Carcinomas
- MRI in cancer diagnosis
- Genetic factors in colorectal cancer
- Hypothalamic control of reproductive hormones
- Breast Cancer Treatment Studies
- Ultrasound Imaging and Elastography
- Photoacoustic and Ultrasonic Imaging
- Radiomics and Machine Learning in Medical Imaging
- Radiation Dose and Imaging
- Gestational Trophoblastic Disease Studies
- Ectopic Pregnancy Diagnosis and Management
- Hepatitis C virus research
- Radiology practices and education
- Spine and Intervertebral Disc Pathology
- Amoebic Infections and Treatments
- Breast Implant and Reconstruction
- Liver Diseases and Immunity
Imperial College Healthcare NHS Trust
2016-2025
University of Oklahoma
2025
Imperial College London
2015-2024
Charing Cross Hospital
2015-2024
Sana Klinikum Lichtenberg
2024
International University of Health and Welfare
2024
Assistance Publique – Hôpitaux de Paris
2024
Memorial Hospital
2024
Tokyo Medical University
2024
Rocky Vista University
2024
Abstract The present, updated document describes the fourth iteration of recommendations for hepatic use contrast enhanced ultrasound (CEUS), first initiated in 2004 by European Federation Societies Ultrasound Medicine and Biology (EFSUMB). previous editions guidelines reflected changes available agents not only but also non-hepatic applications. 2012 guideline requires updating as previously differences were precisely described phases well handling clearly indicated. In addition, more...
Immunosuppressed organ-transplant recipients have an increased incidence of, and mortality from, skin cancer. Nicotinamide (vitamin B3) enhances the repair of ultraviolet (UV) radiation-induced DNA damage, reduces cutaneous immunosuppressive effects UV radiation, keratinocyte cancers (including squamous-cell basal-cell carcinomas) actinic keratoses among high-risk immunocompetent patients. Whether oral nicotinamide is useful for skin-cancer chemoprevention in unclear.In this phase 3 trial,...
Phototherapy — which includes photothermal therapy (PTT) and photodynamic (PDT) has evoked interest as a promising cancer treatment modality on account of its noninvasiveness, spatiotemporal precision, minimal side effects. C. Wang et al. recently reported near‐infrared‐activated charge transfer complex‐based nanoparticle consists donor (D) an acceptor (A). Experimental results have demonstrated potent immunotherapeutic effect integrating programmed cell death protein 1 antibody combination...
A multiplex PCR test based on the simultaneous amplification of two lipoprotein genes, oprI and oprL, was designed evaluated for its ability to directly detect fluorescent pseudomonads (amplification open reading frame, 249 bp) Pseudomonas aeruginosa oprL 504 in clinical material. collection reference strains including 20 different species tested. Positive results both genes were observed only P. isolates (n = 150), environmental origin, while one gene, oprI, amplified from other...
Background: Kisspeptin is a critical regulator of normal reproductive function. A single injection kisspeptin in healthy human volunteers potently stimulates gonadotropin release. However, the effects on release women with hypothalamic amenorrhea (HA) and repeated administration to humans are unknown. Aim: The aim this study was determine acute chronic HA. Methods: We performed prospective, randomized, double-blinded, parallel design study. Women HA received twice-daily sc injections (6.4...
Abstract Background Breast cancer (BC) is the most common in women, and despite introduction of new screening programmes, therapies monitoring technologies, there still a need to develop more useful tests for treatment response inform clinical decision making. The purpose this study was compare circulating cell-free DNA (cfDNA) tumour cells (CTCs) with conventional breast blood biomarkers (CA15-3 alkaline phosphatase (AP)) as predictors prognosis patients metastatic (MBC). Methods One...
Background Variations in lymph node (LN) microcirculation can be indicative of metastasis. The identification and quantification metastatic LNs remains essential for prognosis treatment planning, but a reliable noninvasive imaging technique is lacking. Three-dimensional super-resolution (SR) US has shown potential to noninvasively visualize microvascular networks vivo. Purpose To study the feasibility three-dimensional SR rabbit LN structure blood flow by using microbubbles. Materials...
<b>Background and aims:</b> A reliable non-invasive assessment of the severity diffuse liver disease is much needed. We investigated utility hepatic vein transit times (HVTT) for grading staging in a cohort patients with hepatitis C virus (HCV) infection using an ultrasound microbubble contrast agent as tracer. <b>Materials methods:</b> Eighty five untreated biopsy proven HCV induced were studied prospectively. All RNA positive on polymerase chain reaction testing. Based their histological...
PURPOSE: To evaluate the pharmacokinetics of microbubble contrast agent BR1. MATERIALS AND METHODS: Twenty healthy volunteers were injected via arm vein with a 1.2-mL bolus Ultrasonographic images liver and right kidney spleen left obtained intermittently for 5 minutes low-mechanical-index software (to minimize destruction) that shows stationary microbubbles in green. Percentage total uptake was calculated as number green pixels region interest each organ over time, divided by pixels....
Background and objectives: Encapsulating peritoneal sclerosis (EPS) is a severe fibrotic reaction in patients on long-term dialysis (PD). The early clinical features may be nonspecific. purpose of the study to assess reliability diagnostic utility abdominal CT scanning diagnosis EPS. Design, setting, participants, & measurements: Abdominopelvic scans 27 diagnosed with EPS radiologic grounds our unit from 1997 2006 were retrospectively analyzed. In addition, 35 control scored: 15 hemodialysis...
Kisspeptin is a novel therapeutic target for infertility. A single kisspeptin-54 (KP-54) injection acutely stimulates the release of reproductive hormones in women with hypothalamic amenorrhea (HA), commonly occurring condition characterized by absence menstruation; however, twice-daily administration KP-54 results tachyphylaxis. We determined time course desensitization to injections, compared effects and twice-weekly regimens KP-54, studied long-term on HA. When was administered twice...
The Efficacy of Axillary Ultrasound in the Detection Nodal Metastasis Breast CancerBelinda Lee1, Adrian K. Lim2, Jonathan Krell1, Keshthra Satchithananda2, R. Charles Coombes1, Jacqueline S. Lewis3 and Justin Stebbing1Audio Available | Share
Abstract Background Despite the increasing role of ultrasound, structured ultrasound teaching is only slowly being integrated into curricula medical schools and universities all over Europe. Aim To survey current situation at European regarding integration in student education to report on models training from selected universities. Methods A questionnaire focusing implementation curricular was sent out 28 presidents national societies Federation Societies for Ultrasound Medicine Biology...
Abstract Approximately 30% of ERα breast cancer patients relapse with metastatic disease following adjuvant endocrine therapies. The connection between acquisition drug resistance and invasive potential is poorly understood. In this study, we demonstrate that the type II keratin topological associating domain undergoes epigenetic reprogramming in aromatase inhibitors (AI)-resistant cells, leading to Keratin-80 (KRT80) upregulation. KRT80 expression driven by de novo enhancer activation...
Abstract Dynamic contrast-enhanced ultrasound (DCE-US) is a technique to quantify tissue perfusion based on phase-specific enhancement after the injection of microbubble contrast agents for diagnostic ultrasound. The guidelines European Federation Societies Ultrasound in Medicine and Biology (EFSUMB) published 2004 updated 2008, 2011, 2020 focused use (CEUS), including essential technical requirements, training, investigational procedures steps, guidance regarding image interpretation,...
Liver biopsy remains the gold standard for characterizing diffuse liver disease and is associated with significant morbidity and, rarely, mortality. Our aim was to investigate whether a noninvasive technique, in vivo phosphorus 31 ( P)–magnetic resonance spectroscopy (MRS), could be used assess severity of hepatitis C virus (HCV)–related disease. Fifteen healthy controls 48 patients biopsy–proven HCV–related were studied prospectively. Based on their histologic fibrosis (F) necroinflammatory...
Abstract Background Conventional surgical management of insulinomas involves an open technique. The laparoscopic approach has advantages in terms improved postoperative pain and recovery time. This retrospective study evaluated the pancreatic insulinomas. Methods Between December 2000 March 2007, 23 patients were referred for consideration insulinoma resection. Two not deemed appropriate managed with surgery. All surgery was performed by one experienced surgeon. Laparoscopic intraoperative...