A5024625271- Ultrasound and Hyperthermia Applications
- MRI in cancer diagnosis
- Photoacoustic and Ultrasonic Imaging
- Advanced MRI Techniques and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Angiogenesis and VEGF in Cancer
- Advanced X-ray and CT Imaging
- Inflammatory Myopathies and Dermatomyositis
- Radiation Dose and Imaging
- Peripheral Artery Disease Management
- Cardiac Imaging and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Muscle and Compartmental Disorders
- Heterotopic Ossification and Related Conditions
- Cardiovascular and exercise physiology
- Diagnosis and Treatment of Venous Diseases
- Systemic Sclerosis and Related Diseases
- Hemodynamic Monitoring and Therapy
- Sports injuries and prevention
- Ultrasound in Clinical Applications
- Muscle Physiology and Disorders
- Tendon Structure and Treatment
- Shoulder Injury and Treatment
- Body Composition Measurement Techniques
- Ultrasound Imaging and Elastography
Bracco (Germany)
2010-2025
Sana Klinikum Lichtenberg
2024
University Hospital Heidelberg
2011-2016
Heidelberg University
2005-2016
Bracco (Italy)
2014
German Cancer Research Center
2004-2013
DKFZ-ZMBH Alliance
2003-2011
University of Mannheim
2011
National Center for Tumor Diseases
2007
Altana (Netherlands)
2006-2007
Cancer-related cachexia is an obscure syndrome leading to muscle wasting, reduced physical fitness and quality of life. The aim this study was assess morphology, metabolism, microcirculation in skeletal muscles patients with cancer-related compare these data matched healthy volunteers.In 19 cancer-induced age-, gender-, body-height-matched volunteers body composition aerobic capacity (VO(2max)) were analyzed. Skeletal fiber size capillarization evaluated biopsies the vastus lateralis muscle....
Abstract Dynamic contrast-enhanced ultrasound (DCE-US) is a technique to quantify tissue perfusion based on phase-specific enhancement after the injection of microbubble contrast agents for diagnostic ultrasound. The guidelines European Federation Societies Ultrasound in Medicine and Biology (EFSUMB) published 2004 updated 2008, 2011, 2020 focused use (CEUS), including essential technical requirements, training, investigational procedures steps, guidance regarding image interpretation,...
Purpose: To prospectively determine whether contrast material–enhanced ultrasonography (US) can depict inflammation-induced changes in muscle perfusion for patients suspected of having dermatomyositis or polymyositis and to compare these findings with those magnetic resonance (MR) imaging biopsy. Materials Methods: Institutional review board approval informed consent were obtained. Perfusion skeletal muscles was quantified contrast-enhanced intermittent power Doppler US by applying a...
The purpose of this study was to develop a clinically applicable examination method assess perfusion the skeletal muscle using contrast-enhanced ultrasonography (CEUS) analyzing replenishment kinetics microbubbles.Power Doppler sonography (7 MHz) after intravenous bolus injection 10 mL microbubble contrast agent used repeatedly examine right biceps at rest and defined exercise in healthy volunteers. Parameters perfusion, such as local blood volume, flow velocity, were calculated by modified...
The purpose of our study was the investigation early changes in tumor vascularization during antiangiogenic therapy with vascular endothelial growth factor (VEGF) receptor 2 antibody (DC101) using dynamic contrast-enhanced magnetic resonance imaging (DCE MRI). Subcutaneous heterotransplants human skin squamous cell carcinomas nude mice were treated DC101. Animals examined before and repeatedly weeks treatment Gd-DTPA-enhanced T1-weighted MRI. With a two-compartment model, data parameterized...
The purpose of our study was the investigation early changes in tumor vascularization during antiangiogenic therapy with vascular endothelial growth factor (VEGF) receptor 2 antibody (DC101) using dynamic contrast-enhanced magnetic resonance imaging (DCE MRI). Subcutaneous heterotransplants human skin squamous cell carcinomas nude mice were treated DC101. Animals examined before and repeatedly weeks treatment Gd-DTPA-enhanced T1-weighted MRI. With a two-compartment model, data parameterized...
Objective. The purpose of this study was to compare skeletal muscle perfusion measured by contrast-enhanced ultrasonography (CEUS) with microvascular density in biopsies. Methods. Power Doppler sonography after intravenous bolus injection Levovist (SH U 508A; Schering AG, Berlin, Germany) used examine vastus lateralis 23 healthy volunteers. Local blood volume (B), flow velocity (v), and (f) were calculated analyzing replenishment kinetics. CEUS compared vascularization biopsy samples from...
Objective: This feasibility study was performed to assess whether dynamic contrast-enhanced ultrasound (CEUS) and transient arterial occlusion are able detect alterations in the microvascular perfusion reserve patients suffering from peripheral disease (PAD) comparison with healthy volunteers. Materials Methods: Twenty PAD, Rutherford classification grade I, category III (mean age, 64 years; mean height, 173 cm; weight, 81.8 kg), 20 volunteers 50 174 77.8 kg) participated study....
Bone regeneration depends on perfusion of the fracture tissue, whereby hypervascularity is associated with infection, which itself causes nonunions. To date, nonunion has not been assessed contrast-enhanced sonography. The aim this study was to evaluate potential sonography in analysis tissue perfusion.Nonunion vascularity 31 patients before revision surgery prospectively examined qualitative and dynamic magnetic resonance imaging (MRI). Time-intensity curves from 2-minute sonographic video...
Rationale: Angiogenesis is essential for spread and growth of malignant tumors. Because noninvasive methods observing tumor vascularization are limited, most previous results were based on histologic findings alone. In this study, dynamic parameters obtained using intermittent contrast-enhanced Doppler sonography MRI compared correlated with microvessel density. Methods: Eleven tumor-bearing nude mice examined T1-weighted sequences Gd-DTPA in a 1.5 T magnetic resonance (MR) scanner power...