A5091161864- Bone fractures and treatments
- Hip and Femur Fractures
- Orthopaedic implants and arthroplasty
- AI-based Problem Solving and Planning
- Semantic Web and Ontologies
- Spinal Fractures and Fixation Techniques
- Shoulder and Clavicle Injuries
- Orthopedic Infections and Treatments
- Simulation-Based Education in Healthcare
- Shoulder Injury and Treatment
- Logic, Reasoning, and Knowledge
- Orthopedic Surgery and Rehabilitation
- Surgical Simulation and Training
- Bayesian Modeling and Causal Inference
- Total Knee Arthroplasty Outcomes
- Pelvic and Acetabular Injuries
- Innovations in Medical Education
- Management of metastatic bone disease
- Trauma Management and Diagnosis
- Nerve Injury and Rehabilitation
- Spine and Intervertebral Disc Pathology
- Philosophy and History of Science
- Bone Tissue Engineering Materials
- Explainable Artificial Intelligence (XAI)
- Biomedical Text Mining and Ontologies
University Hospital Heidelberg
2014-2025
Heidelberg University
2015-2025
New York University
2024
Kansas State University
2022
Cataract and Refractive Institute of Florida
2018
American Society of Colon and Rectal Surgeons
2018
Beaumont Hospital, Troy
2018
Oakland University
2018
Institute For Defense Analyses
2002
George Mason University
1991-2002
A general problem-solving mechanism is described that especially suited for performing a particular form of abductive inference, or best explanation finding. problem solver embodying this synthesizes composite hypotheses by combining simple to satisfy explanatory goals. These are formed instantiating prestored "concepts." In way the able arrive at complex integrated conclusions which not prestored. computationally feasible task-specific presented information-processing task is, nevertheless,...
Explaining how knowledge-based systems reason involves presentation user modeling, dialogue structure, and the way understand their own problem-solving knowledge strategies. The authors concentrate on last of these, noting that such understanding provides any explanations's content. also note most current approaches to system construction require expressing control at low levels it's hard give high-level explanations. Providing an explanation example from a prototypical (MYCIN) built using...
Methods Between 2005 and 2012, 50 patients (23 female, 27 male) with nonunion of the humeral shaft were included in this retrospective study. The mean age was 51.3 years (14 to 88). had a 1.5 prior operations (sd 1.2;1 8). All assessed according specific risk score order devise an optimal individual therapy plan consistent Diamond Concept. In 32 cases (64%), change osteosynthesis angular stable locking compression plate performed. According additional bone graft and/or morphogenetic...
The insertion of a chest tube should be as quick and accurate possible to maximize the benefit minimize complications for patient. Therefore, comprehensive training assessment before an emergency situation are essential proficiency in insertion. Serious games have become more prevalent surgical because they enable students study train procedure independently, errors made no effect on patients. However, up-to-date evidence regarding serious performance procedures medicine remains scarce.The...
Abstract Background This retrospective study of 73 myeloma patients with painful vertebral lesions compares clinical and radiomorphological outcomes up to 2 years after additional kyphoplasty, radiation therapy or systemic treatment only. Methods We assessed pain, disability parameters by visual analogue scale (VAS 0‐100), Oswestry Disability Index re‐evaluating available follow‐up X‐rays, respectively, in that were treated according a pathway. Results After the VAS score was reduced all...
Bone regeneration depends on perfusion of the fracture tissue, whereby hypervascularity is associated with infection, which itself causes nonunions. To date, nonunion has not been assessed contrast-enhanced sonography. The aim this study was to evaluate potential sonography in analysis tissue perfusion.Nonunion vascularity 31 patients before revision surgery prospectively examined qualitative and dynamic magnetic resonance imaging (MRI). Time-intensity curves from 2-minute sonographic video...
Autologous bone grafting (ABG) remains the gold standard for augmentation of defects. The RIA system has become more prevalent, but evidence regarding risk management and complications remain scarce. This study presents associated with in largest single-center case series to date.All records, operative notes, lab data radiographs patients receiving a procedure at Heidelberg´s University Hospital between 01/01/2010 31/12/2016 were reviewed. Multivariate logistic regression models adjusting...
In our cohort of 555 patients with a total 1150 vertebral fractures treated kyphoplasty we performed 30-day postoperative analysis cement leakage, neurological symptoms, pulmonary embolism, and infections. department, 22% kyphoplasties were calcium phosphate the remainder polymethylmethacrylate. All initially assessed by an interdisciplinary colloquium, composed consultants in traumatology, radiology, endocrinology. Indications included fresh traumatic fractures; painful sintered...
Aims The aim of this study was to evaluate the radiological outcome patients with large bone defects in femur and tibia who were treated according guidelines diamond concept our department (Centre for Orthopedics, Trauma Surgery, Paraplegiology). Methods following retrospective, descriptive analysis consists between January 2010 December 2021. In total, 628 registered, whom 108 presented a large-sized defect (≥ 5 cm). A total 70 met inclusion criteria. primary endpoint consolidation...
Abstract Compared to other long bones, non-unions of the tibia after fractures are more likely. Due surgical debridement, residual bone stock in distal part may be insufficient for adequate fixation an implant. Thus, treatment with a retrograde nail additional performance arthrodesis hindfoot alternative. The aim this study was examine consolidation and reinfection rates treated nail. A total 27 patients between 2010 2018 were included according our inclusion criteria. modified Lane Sandhu...
Structural extracellular matrix molecules gain increasing attention as scaffolds for cartilage tissue engineering owing to their natural role a growth factor repository. We recently observed that collagen-type I/III (Col-I/III) matrix, human recombinant transforming factor-beta (TGF-β) protein, and fibrin hydrogel (FG) combined biphasic construct provided sufficient long-term TGF-β support drive in vitro chondrogenesis of mesenchymal stem cells (hMSC). Here we ask whether FG Col-I/III can...
Treatment of non-union remains challenging and often necessitates augmentation the resulting defect with an autologous bone graft (ABG). ABG is limited in quantity its harvesting incurs additional surgical intervention leaving risk for associated complications morbidities. Therefore, artificial substitutes that might replace are needed. S53P4-type bioactive glass (BaG) a promising material which be used as substitute due to osteostimulative, conductive antimicrobial properties. In this...
The treatment of large-sized bone defects remains a major challenge in trauma and orthopaedic surgery. Although there are many options, is still no clear guidance on surgical management, the influence defect size radiological clinical outcome unclear due to small number affected patients. aim present study was determine atrophic infected nonunions tibia or femur based diamond concept order provide recommendations for guidance.All medical records, reports, laboratory data images patients...
An investigation of explanation (the process by which an expert system explains how it arrived at a particular solution) in the domains logistics planning and diagnosis is discussed. The research was performed as part Strategic Computing Initiative US Dept. Defense's Defence Advanced Research Projects Agency (DARPA). Types aspects are examined. generic task approach to generating explanations problem-solving strategies steps its implementation Mission Planning Assistant (MPA), plans kind Air...
Eleven patients with painful osteoporotic vertebral fractures who underwent kyphoplasty using calcium phosphate (CaP) cement were followed up for 1 week, 1, 2, and 3 years in a monocentric, nonrandomized, noncontrolled retrospective trial.This study investigates long-term radiomorphologic features of intraosseous CaP implants extraosseous leakages to after implantation by kyphoplasty.Kyphoplasty is frequently used the treatment fractures. Of materials available, as filling material....
Chest tube insertion is a standard intervention for management of various injuries the thorax. Quick and accurate execution facilitates efficient therapy without further complications. Here, we propose new training concept comprised e-learning elements as well continuous rating using an objective structured assessment technical skills (OSATS) tool. The study protocol presented randomized trial to evaluate with app-based serious gaming chest drain insertion. proposed will be carried out at...