A5043470288- Cardiac tumors and thrombi
- Lung Cancer Treatments and Mutations
- Sarcoma Diagnosis and Treatment
- Cutaneous Melanoma Detection and Management
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Nonmelanoma Skin Cancer Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer and Skin Lesions
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging and Pathology Studies
- Cancer Genomics and Diagnostics
- Infectious Diseases and Mycology
- Peptidase Inhibition and Analysis
- Lymphoma Diagnosis and Treatment
- Polyomavirus and related diseases
- Colorectal Cancer Screening and Detection
- Cutaneous lymphoproliferative disorders research
- Immunotherapy and Immune Responses
- Breast Lesions and Carcinomas
- Aortic aneurysm repair treatments
- Vascular Tumors and Angiosarcomas
- Vascular Malformations and Hemangiomas
- RNA modifications and cancer
- Sarcoidosis and Beryllium Toxicity Research
Sunshine Coast University Hospital
2015-2025
University of the Sunshine Coast
2022-2025
Sullivan Nicolaides Pathology
2015-2025
Queensland Health
2004-2024
The University of Sydney
2023
Melanoma Institute Australia
2023
Griffith University
2014-2022
Nambour General Hospital
2015-2018
Prince Charles Hospital
2009-2015
The University of Queensland
2012-2015
Immunosuppressed organ-transplant recipients have an increased incidence of, and mortality from, skin cancer. Nicotinamide (vitamin B3) enhances the repair of ultraviolet (UV) radiation-induced DNA damage, reduces cutaneous immunosuppressive effects UV radiation, keratinocyte cancers (including squamous-cell basal-cell carcinomas) actinic keratoses among high-risk immunocompetent patients. Whether oral nicotinamide is useful for skin-cancer chemoprevention in unclear.In this phase 3 trial,...
In animal models and human cerebral arteries, the changes in endothelial cell (EC)-large conductance calcium-activated potassium channel (BKCa) distribution, expression, function were determined hypoxia ischemic stroke. The hypothesis that stroke induce EC-BKCa arteries was examined. Immunohistochemistry analyzed BKCa expression EC smooth muscle (SM) of middle-cerebral artery (MCA) from rat, piglet, mouse, pial arteriole human. Pressure myography with pharmacological intervention...
ABSTRACT Background Australia introduced structured pathology reporting guidelines for non‐melanoma skin cancer (NMSC) including cutaneous squamous cell carcinoma (cSCC) in 2023 to encourage accurate histological assessment and recording of well recognised adverse prognostic factors that inform prognosis the need additional treatment. Deaths from are increasing. Identifying high‐risk cSCC (HRcSCC) cases early is critical, pathologist has a central role play. Objectives To establish...
We report two cases of atypical fibroxanthoma (AFX) that both had the previously unreported feature neural invasion (one perineural and other intraneural). AFXs recur in approximately 10% but only rarely metastasize. Features associated with recurrence are inadequate excision into fat. metastasis include recurrence, vascular invasion, deep tissue tumor necrosis. Both these tumors invaded deeply subcutaneous fat reached fascia. Some authors would regard such as malignant fibrous histiocytoma...
Abstract The global landscape of molecular testing is rapidly changing, with the recent publication I nternational A ssociation for S tudy L ung C ancer ( IASLC )/ ollege merican P athologists CAP ) guidelines and ALK tlas. / recommend that tumors from patients non‐small cell lung cancer NSCLC be tested rearrangements in addition to epidermal growth factor receptor EGFR mutations. spur this recommendation availability novel therapies target these rearrangements. This article based on...
A man in his 50s presented with an ulcerative lesion within the left axillary fold that had progressively worsened over 18 months. Biopsy revealed basal cell carcinoma (BCC), which was surgically managed. CT chest scans done 7 months later assessed post-treatment of radiotherapy. This pulmonary lesions, were biopsy-proven metastatic BCC. Sonidegib, a hedgehog signalling inhibitor, used for first-line treatment. Due to progressive disease, sonidegib ceased. Cemiplimab, checkpoint as...
Primary rectal melanoma is rare and only represents up to 4% of anorectal malignancies. The prognosis such a diagnosis significantly different metastatic deposit in the area therefore differentiation between two utmost importance with regards initial treatment long-term management. Various immunohistochemical markers have been shown be associated primary strongly aid diagnosis. Surgical management still widely disputed multiple papers published comparing wide local excision abdominoperineal...
Sweet’s syndrome is an acute febrile neutrophilic dermatosis. Drug-induced typically occurs soon after drug administration, with rapid resolution of symptoms cessation the offending agent. We report a man in his early 40s who presented fever and widespread erythematous rash on background recently diagnosed mild stricturing ileal Crohn’s disease. He was commenced 6-mercaptopurine 12 days before presentation. Skin biopsy demonstrated diffuse infiltration neutrophils upper dermis, dermal...
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A 37-year-old patient with type 1 diabetes had been recently diagnosed collagenous colitis (CC) after sigmoidoscopy. She rapidly progressed from a fortnight of watery diarrhoea, to malabsorptive state severe dehydration and acute kidney injury. This necessitated admission an intensive care unit for emergency dialysis. was subsequently enterocolitis affecting gastric, small bowel colonic mucosa which required systemic steroid therapy. Physicians caring patients CC should be aware the...
A papillary fibroelastoma is a rare, avascular, cardiac tumour that often found incidentally using transthoracic echocardiography (TTE). Peripheral i.v. injection of microbubble contrast agent used to characterize abnormal masses within the heart allowing further delineation physical features, area attachment, and vascularity mass in order differentiate growth from or thrombus. This case highlights potential pitfall when assessing tumour's TTE. was identified on TTE 53-year-old man...
Abstract Granulocytic sarcoma is a rare manifestation of myeloid leukemia and even rarer as primary presentation. may affect any organ has many modes Diagnosis by cytology possible long the diagnosis considered. body cavity effusion fluid rarely been described. We present an unusual case granulocytic in which pleural was part initial Cytologic examination able to make definitive sarcoma. Diagn. Cytopathol. 2004;31:126–128. © 2004 Wiley‐Liss, Inc.
We present the case of a 26‐year‐old stonemason with accelerated silicosis in setting treatment for psoriasis tumour necrosis factor alpha ( TNF ‐alpha) inhibitor adalimumab. Accelerated is an important occupational lung disease poor prognosis and limited options [1]. Although exact pathogenesis remains unknown, it suggested that secretion cytokines, including ‐alpha, plays central role progression [1,2]. Importantly, however, ‐alpha inhibitors, addition to resulting increased risk...
A 20-year-old female with a 12-year history of hypertrophic obstructive cardiomyopathy (HOCM) progressive right ventricular outflow obstruction (RVOTO) and mild left (LVOTO) was referred to our institution for consideration septal myomectomy due symptomatic tract obstruction. The patient had New York Heart Association Class III dyspnoea, abdominal bloating, nausea, vomiting palpitations presyncope on standing or walking up stairs. Examination revealed …