A5004134442- Cancer and Skin Lesions
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Tumors and Oncological Cases
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Ear and Head Tumors
- Sarcoma Diagnosis and Treatment
- Nonmelanoma Skin Cancer Studies
- Histiocytic Disorders and Treatments
- Genetic factors in colorectal cancer
- Vascular Tumors and Angiosarcomas
- Cutaneous lymphoproliferative disorders research
- Glioma Diagnosis and Treatment
- Hedgehog Signaling Pathway Studies
- Neurofibromatosis and Schwannoma Cases
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Salivary Gland Tumors Diagnosis and Treatment
- Soft tissue tumor case studies
- Neuroblastoma Research and Treatments
- Oral and Maxillofacial Pathology
- Occupational and environmental lung diseases
- Cancer, Hypoxia, and Metabolism
- CNS Lymphoma Diagnosis and Treatment
Pathwest Laboratory Medicine
2012-2021
The University of Western Australia
2012-2021
The University of Notre Dame Australia
2017-2020
Queen Elizabeth II Medical Centre
2010-2019
Sir Charles Gairdner Hospital
1983-2014
King Edward Memorial Hospital
2014
South Australia Pathology
1995-2012
Charles University
2010
Harry Perkins Institute of Medical Research
1998-2004
The Alfred Hospital
1998
The clinical, histologic, immunophenotypic, ultrastructural, and molecular features of a distinctive gastrointestinal tumor are described. Sixteen patients, 8 women men aged 17 to 77 years (mean age, 42 y; 63% less than 40 y) presented with abdominal pain, intestinal obstruction, an mass. Mean size was 5.2 cm (range, 2.4 15.0 cm). tumors arose in the small bowel (10), stomach (4), colon (2) were histologically characterized by sheet-like or nested population epithelioid oval-to-spindle cells...
BACKGROUND A preoperative diagnosis of medullary carcinoma the thyroid (MCT) allows for investigation associated multiple endocrine neoplasia/pheochromocytoma, and definitive surgery without need frozen section. Criteria cytodiagnosis are well known but variable patterns presentation may cause diagnostic difficulty. METHODS This study examines accuracy value ancillary tests in 17 patients seen between 1976 1997. Nine underwent gland aspirations, five fine-needle aspiration (FNA) cervical...
The authors present a series of 24 malignant neoplasms arising in preexisting benign spiradenoma (20), cylindroma (2), and spiradenocylindroma (2). Nineteen patients (12 females, 7 males; age range, 41 to 92 y) had solitary neoplasm (size 2.2 17.5 cm; median 4 cm), whereas the remaining 5 (4 1 male; 66 72 manifested clinical features Brooke-Spiegler syndrome (BSS), an autosomal dominantly inherited disease characterized by widespread, small, on which background larger lesions appeared....
Two cases of colliding gastric adenocarcinoma and esophageal squamous cell carcinoma are presented. The occurrence carcinomas mixed histological type at the esophagogastric junction is uncommon, collision being particularly rare. Criteria problems in diagnosis reviewed discussed. It suggested that, although undoubtedly this site may occur more frequently than previously reported.
We present a series of 14 cases cutaneous hidradenocarcinomas. The patients included 6 women and 8 men ranging in age at diagnosis from 34 to 93 years. All but 1 patient presented with solitary nodule. There was no predilection site. One multiple lesions representing metastatic nodules. Of 12 available follow-up, 2 died disease, whereas the remaining 10 were alive 3 them experienced local recurrence course disease. Grossly, tumors ranged size 1.2 cm. Microscopically, primary tumors, 9 showed...
Extraskeletal myxoid chondrosarcoma: a light microscopic, immunohistochemical, ultrastructural and immuno‐ultrastructural study indicating neuroendocrine differentiation Aims : chondrosarcoma is rare low‐grade soft‐tissue sarcoma with locally aggressive metastasizing potential. has distinctive clinical, immunophenotypic, cytogenetic features. Evidence that extraskeletal often shows features was first provided by Chhieng et al. 9 on the basis of an immunohistochemical seven cases. Our aims to...
Indeterminate cell tumor (ICT) is a rare neoplastic dendritic disorder that has been poorly defined due to its rarity and understood histogenesis pathogenesis. It characterized by proliferation of cells, which mimic Langerhans cells immunophenotypically (positive for CD1a S-100 protein), but lack Birbeck granules characteristic cells. The clinical, morphologic, immunophenotypic, ultrastructural features 5 ICT cases are reported in an attempt further define examine the postulated relationship...
We report 18 cases of primary cutaneous neuroendocrine carcinoma (CNEC, Merkel cell tumor) that occurred mainly in the sun-exposed skin elderly patients as dermal and subcutaneous masses generally monomorphic cells with foci pronounced pleomorphism. All showed immunoreactivity for neuron-specific enolase (NSE), whereas 16 them another marker, protein gene product 9.5 (PGP 9.5). Positivity PGP was more intense sharply localized to tumor than staining NSE. Immunoreactivity keratins detected by...
The authors present a series of 13 fibroepithelial neoplasms involving anogenital mammary-like glands, all occurring in 12 female patients, whose age at diagnosis ranged from 30 to 51 years (mean, 38 y; median, 42 y). All women presented with solitary asymptomatic nodule the vulva (n=8), perineum (n=2), or near anus (n=2) ranging size 1.5 4.5 cm. Microscopically, 8 lesions were classified as fibroadenoma, and 5, including 1 recurrent tumor, phyllodes which was benign 4 low-grade malignant....
Hidradenoma papilliferum (HP) is a benign cutaneous adnexal neoplasm occurring mainly in the anogenital region of adult women and has features analogous to intraductal papilloma breast. Malignant change HP extremely rare. Only single case ductal carcinoma situ arising been previously reported. We present new which, addition typical appearance HP, contained focus that appeared as enlarged pleomorphic epithelial cells having "blastic" appearance, exhibiting atypical mitotic figures surrounded...
The pathologic diagnosis of adrenocortical carcinoma (ACC) relies on microscopic features that are sometimes equivocal in special variants, including oncocytic tumors (OACTs). We report a series 27 unpublished OACTs (15 pure and 12 mixed or focal) assess for the first time diagnostic utility an algorithm recently proposed by our group ("reticulin" algorithm) conventional ACCs basis combination reticulin staining assessment only 3 Weiss parameters. Overall, cases were malignant according to...
Brooke-Spiegler syndrome (BSS) is a rare, inherited, autosomal dominant disorder characterized by development of multiple adnexal cutaneous neoplasms including spiradenoma, cylindroma, spiradenocylindroma, and trichoepithelioma. The familial trichoepitheliomas (MFT) considered phenotypic variant BSS in which patients present with only. We studied germline somatic mutations the CYLD gene direct sequencing (n = 49) MFT 18) using peripheral blood 90 samples frozen or formalin-fixed...
Hidradenoma papilliferum (HP), also known as papillary hidradenoma, is the most common benign lesion of female anogenital area derived from mammary-like glands (AGMLG). HP can be viewed conceptually cutaneous counterpart mammary intraductal papilloma. The authors have studied 264 cases HP, detailing various changes in tumor and adjacent AGMLG, with emphasis on mammary-type alterations. In many noticed typical for breast lesions, such sclerosing adenosis-like changes, usual, atypical ductal...
We describe 11 poroid neoplasms with sebaceous differentiation, including a metaplastic (sarcomatoid) carcinoma arising in association an apocrine poroma. Six lesions had the silhouette of classical poroma, 3 hidradenoma and 1 dermal duct tumor. In all cases, differentiation was identified as clustered or solitary, mature sebocytes occurring mainly at periphery intradermal cellular aggregations, accompanied by ducts. one clusters were seen within aggregates intraepidermally. hidradenomas,...
Tubular adenoma (TA) and syringocystadenoma papilliferum (SCAP) may show histopathological overlap, with some lesions having features of both neoplasms (SCAP + TA). TA has been recently suggested to represent a carcinoma. Four observers blindly assessed 67 cases TA, SCAP, their lookalikes (poroma, apocrine adenoma, carcinoma; all focally featuring pseudopapillary pattern), classified the into one four categories: (1) (2) (3) SCAP (4) others. Lesions were also as benign or malignant. In only...