A5042477207- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- Multiple Myeloma Research and Treatments
- Histiocytic Disorders and Treatments
- Metabolism, Diabetes, and Cancer
- Acute Myeloid Leukemia Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Immunotherapy and Immune Responses
- Cancer-related Molecular Pathways
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders Research
- CNS Lymphoma Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Parvovirus B19 Infection Studies
- Thyroid Cancer Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Tumors and Oncological Cases
- Cancer Genomics and Diagnostics
- Chronic Myeloid Leukemia Treatments
- Peptidase Inhibition and Analysis
- Acute Lymphoblastic Leukemia research
- Hematological disorders and diagnostics
- Hematopoietic Stem Cell Transplantation
- Cancer Risks and Factors
University of California, Irvine
2013-2025
University of California, Irvine Medical Center
2013-2025
UC Irvine Health
2021
Benha University
2021
University of California San Francisco Medical Center
2015
University of Southern California
2001-2015
Framingham State University
2012-2013
University of Massachusetts Chan Medical School
2004-2007
City Of Hope National Medical Center
2007
UMass Memorial Medical Center
2004-2005
Indeterminate cell tumor (ICT) is a rare neoplastic dendritic disorder that has been poorly defined due to its rarity and understood histogenesis pathogenesis. It characterized by proliferation of cells, which mimic Langerhans cells immunophenotypically (positive for CD1a S-100 protein), but lack Birbeck granules characteristic cells. The clinical, morphologic, immunophenotypic, ultrastructural features 5 ICT cases are reported in an attempt further define examine the postulated relationship...
Cyclin D1 and E2F-1 proteins are essential for the regulation of G1/S transition through cell cycle. D1, a product bcl-1 gene, phosphorylates retinoblastoma protein, releasing E2F-1, which in turn activates genes involved DNA synthesis. Expression patterns protein thyroid proliferations have not been reported. This study used monoclonal antibodies cyclin to immunostain sections normal thyroid, hyperplastic (cellular) nodules, follicular adenomas, carcinomas, papillary carcinomas. The...
ABSTRACT Background Data on bone marrow (BM) findings in secondary hemophagocytic lymphohistiocytosis (sHLH) and their association with overall survival (OS) are limited. Objectives This study aimed to develop a prognostic model incorporating BM clinico‐laboratory factors affecting OS. Methods We retrospectively evaluated 50 adults sHLH developed clinicopathological based survival‐associated factors. Results Most patients demonstrated normocellular (46.3%) mild activity (44.2%). Factors...
Obesity is associated with risk of colorectal adenoma (CRA) and cancer. The signaling pathway activated by metformin (LKB1/AMPK/mTOR) implicated in tumor suppression ApcMin/+ mice via metformin-induced reduction polyp burden, increased ratio pAMPK/AMPK, decreased pmTOR/mTOR ratio, pS6Ser235/S6Ser235 polyps. We hypothesized that would affect tissue S6Ser235 among obese patients recent history CRA. A phase IIa clinical biomarker trial was conducted the U.S. National Cancer...
Thyroid-like follicular carcinoma of the kidney (TLFCK) is a rare histological variant renal cell not currently included in World Health Organization classification tumors. Only 24 previous cases TLFCK have been reported to date. We report case 19-year-old woman with history pediatric acute lymphoblastic leukemia. This patient youngest be date and first The development young leukemia interesting suggests that genes involved leukemogenesis may also important for pathogenesis. Recognition...
Study utility of seven automated VCS parameters (V-volume, C-conductivity and S-scatter) in leukocytes as an objective read-out dysplasia Myelodysplastic Syndromes (MDS).Peripheral blood was analyzed by Beckman-Coulter DxH800 hematology analyzer 43 patients with low-grade, high-grade MDS 21 control individuals. The differences mean (MN) standard deviation (SD) each parameter were examined. optimal sensitivity specificity to predict determined statistical analysis.In neutrophils, all means...
Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening, hyperinflammatory syndrome usually treated with high-dose steroids (HDS), often complemented adjunct therapies, such as etoposide (HLH-94 protocol). Anakinra has been reported to effectively treat HLH; however, not comparatively examined etoposide-based therapies. We sought evaluate the effectiveness and durability of these treatment approaches.We performed retrospective analysis all adult patients diagnosed secondary HLH...
Lymphoid aggregates are seen in a minority of bone marrow biopsy specimens, and when present, their neoplastic nature is often apparent by morphologic evaluation. However, the distinction between benign malignant can be diagnostic challenge there multiple with no documented history lymphoma.To aid B-cell lymphoid aggregates.Previously, we described specific distribution patterns for B T lymphocytes within aggregates. To statistically analyze significance these as well previously reported...
Abstract Solitary fibrous tumor (SFT) is an uncommon spindle cell neoplasm of increasing incidence that was originally described to be pleural origin; however, more recently, SFT has been reported in extrapleural sites, including the orbit, liver, salivary glands, tongue, nose, paranasal sinuses, larynx, retroperitoneum, meninges, and thyroid. The increase number SFTs does not necessarily mean increased this but rather understanding tumor, especially recognition locations, which aided by...
Extraosseous (extramedullary) plasmacytoma is a relatively indolent neoplasm that constitutes 3–5% of all plasma cell neoplasms. Rare cases have been reported to truly occur in the CNS and not as an extension from nasal lesion. EBV expression neoplasms has very few are mainly post‐transplant or occurring severely immunosuppressed patients. We report case extraosseous with aggressive course HIV ‐positive individual occurred solely , showing by situ hybridization, presenting intraparenchymal...
Epstein-Barr virus (EBV) expression has been reported in several hematopoietic and non-hematopoietic disorders but its plasma cell neoplasms largely limited to immunodeficiency-related cases such as the setting of post-organ transplantation or human immunodeficiency (HIV) infection. The aim this study is evaluate association EBV with neoplasms, mainly immunocompetent patients.We retrospectively studied 147 patients different (109 myelomas, 22 plasmacytomas, 16 monoclonal gammopathy cases)....