A5059327228- Salivary Gland Tumors Diagnosis and Treatment
- Cancer and Skin Lesions
- Ear and Head Tumors
- Renal cell carcinoma treatment
- Renal and related cancers
- Tumors and Oncological Cases
- Cancer Genomics and Diagnostics
- Oral and Maxillofacial Pathology
- Sarcoma Diagnosis and Treatment
- Soft tissue tumor case studies
- Forensic and Genetic Research
- Gastrointestinal Tumor Research and Treatment
- Hedgehog Signaling Pathway Studies
- Yersinia bacterium, plague, ectoparasites research
- Bladder and Urothelial Cancer Treatments
- Vascular Tumors and Angiosarcomas
- Nonmelanoma Skin Cancer Studies
- Cutaneous lymphoproliferative disorders research
- Neuroblastoma Research and Treatments
- Tuberous Sclerosis Complex Research
- Urologic and reproductive health conditions
- Head and Neck Surgical Oncology
- Lymphoma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Forensic Anthropology and Bioarchaeology Studies
Biopticka Laborator (Czechia)
2016-2025
Charles University
2016-2025
Pilsen Tools (Czechia)
2014-2025
University Hospital Plzen
2004-2025
Laboratory of Molecular Genetics
2009
Institute of Biological Problems of the North
2008
Russian Academy of Sciences
2008
Weatherford College
2007
University of South Bohemia in České Budějovice
2005
Innsbruck Medical University
2005
We present a series of 16 salivary gland tumors with histomorphologic and immunohistochemical features reminiscent secretory carcinoma the breast. This is hitherto undescribed distinctive neoplasm, resembling both acinic cell (AciCC) low-grade cystadenocarcinoma, displaying strong similarities to breast carcinoma. Microscopically, have lobulated growth pattern are composed microcystic glandular spaces abundant eosinophilic homogenous or bubbly material positive for periodic acid-Schiff,...
Mammary analogue secretory carcinoma of salivary gland origin (MASC) is a recently described tumor resembling the breast characterized by strong S-100 protein, mammaglobin, and vimentin immunoexpression which harbors t(12;15) (p13;q25) translocation resulting in ETV6-NTRK3 fusion product. Histologically, conventional MASC displays bland histomorphology lobulated growth pattern often composed microcystic, tubular, solid structures with abundant eosinophilic homogenous or bubbly secretions....
ETV6 gene abnormalities are well described in tumor pathology. Many fusion partners of have been reported a variety epithelial and hematological malignancies. In salivary gland pathology, however, the ETV6-NTRK3 translocation is specific for mammary analogue secretory carcinoma (MASC), has not documented any other type. The present study comprised clinical molecular analysis 25 cases morphologically immunohistochemically typical MASC. They all also displayed rearrangement as visualized by...
ETV6 gene abnormalities are well described in tumor pathology. Many fusion partners of have been reported a variety epithelial, mesenchymal, and hematological malignancies. In salivary gland pathology, however, the ETV6-NTRK3 translocation is specific for (mammary analog) secretory carcinoma, has not documented any other type. The present study comprised clinical, histologic, molecular analysis 10 cases with typical morphology immunoprofile harboring novel ETV6-RET translocation.
This study examines the presence of EWSR1 rearrangement in a variety clear cell salivary gland carcinomas with myoepithelial differentiation. A total 94 prominent component included 51 cases de novo (CCMC), 21 CCMCs ex pleomorphic adenoma (CCMCexPA), 11 epithelial-myoepithelial carcinoma (EMC), 6 EMC solid overgrowth, and 5 hyalinizing minor glands. In addition, 10 devoid change 12 benign myoepithelioma were as well. All tumors this spectrum reviewed, reclassified, tested by fluorescence...
The authors present a series of 24 malignant neoplasms arising in preexisting benign spiradenoma (20), cylindroma (2), and spiradenocylindroma (2). Nineteen patients (12 females, 7 males; age range, 41 to 92 y) had solitary neoplasm (size 2.2 17.5 cm; median 4 cm), whereas the remaining 5 (4 1 male; 66 72 manifested clinical features Brooke-Spiegler syndrome (BSS), an autosomal dominantly inherited disease characterized by widespread, small, on which background larger lesions appeared....
Intraductal carcinoma (IC) is the new World Health Organization designation for tumors previously called "low-grade cribriform cystadenocarcinoma" and salivary duct carcinoma." The relationship of IC to controversial, but they now are considered be distinct entities. a rare low-grade malignant gland neoplasm with features similar mammary atypical ductal hyperplasia or in situ, that shows diffuse S100 protein mammaglobin positivity only partially defined genetically. (Mammary analogue)...
Intraductal carcinoma (IC) is the new WHO designation for tumors previously encompassed by "low-grade cribriform cystadenocarcinoma" and salivary duct carcinoma." The relationship of IC to (SDC) controversial, even though they are considered be distinct entities. a rare low-grade malignant gland neoplasm with histopathological features reminiscent atypical ductal hyperplasia or in situ breast, showing diffuse S100 protein mammaglobin positivity, while it partially defined genetically....
Background: Secretory carcinoma (SC), originally described as mammary analogue SC, is a predominantly low-grade salivary gland neoplasm characterized by recurrent t(12;15)(p13;q25) translocation, resulting in ETV6-NTRK3 gene fusion. Recently, alternative ETV6-RET , ETV6-MAML3 and ETV6-MET fusions have been found subset of SCs lacking the classic fusion transcript, but still harboring ETV6 rearrangements. Design: Forty-nine cases SC revealing typical histomorphology immunoprofile were...
Abstract Alterations in kinase genes such as NTRK1/2/3 , RET and BRAF underlie infantile fibrosarcoma (IFS), the emerging entity ‘ NTRK ‐rearranged spindle cell neoplasms’ included latest WHO classification, a growing set of tumors with overlapping clinical pathological features. In this study, we conducted comprehensive clinicopathological molecular analysis 22 cases IFS other gene‐altered neoplasms affecting both pediatric adult patients. Follow‐up periods for 16 patients ranged length...
Salivary duct carcinoma is a highly malignant salivary gland tumour with aggressive clinical behaviour, characterized by histological resemblance to invasive ductal of the breast. Amplification HER-2/neu oncogene and over-expression its gene product have both prognostic therapeutic implications in breast cancer. Recent report on carcinomas for using immunohistochemistry (IHC) has shown most cases. However, correlation between IHC molecular genetic analysis not yet been performed.We now...
We present the largest series of mucinous carcinoma involving skin, describing histopathologic, immunohistochemical, electron microscopic, and cytogenetic findings. Our aim was fully to characterize clinicopathologic spectrum compare it with that seen in breast. In addition, we wished reevaluate differential diagnostic criteria for distinguishing primary carcinomas from histologically similar neoplasms skin secondarily, study some aspects their pathogenesis. demonstrate cutaneous span a...
High-grade transformation of acinic cell carcinoma (AciCC) (previously referred to as dedifferentiation) is a rare phenomenon characterized by histologic progression low-grade AciCC high-grade adenocarcinoma or undifferentiated carcinoma. We report 9 new cases with immunohistochemical analysis and examination HER-2/neu p53 genes further define the profile this tumor. Histologically, component was composed polymorphic cells high mitotic rate arranged in glandular solid growth patterns...
It is generally accepted that the most ancient European mitochondrial haplogroup, U5, has evolved essentially in Europe. To resolve phylogeny of this we completely sequenced 113 genomes (79 U5a and 34 U5b) central eastern Europeans (Czechs, Slovaks, Poles, Russians Belorussians), reconstructed a detailed phylogenetic tree, incorporates previously published data. Molecular dating suggests coalescence time estimate for U5 approximately 25-30 thousand years (ky), 16-20 20-24 ky its...
We present a series of 14 cases cutaneous hidradenocarcinomas. The patients included 6 women and 8 men ranging in age at diagnosis from 34 to 93 years. All but 1 patient presented with solitary nodule. There was no predilection site. One multiple lesions representing metastatic nodules. Of 12 available follow-up, 2 died disease, whereas the remaining 10 were alive 3 them experienced local recurrence course disease. Grossly, tumors ranged size 1.2 cm. Microscopically, primary tumors, 9 showed...
Myoepithelial carcinoma of salivary glands is an underrecognized and challenging entity with a broad morphologic spectrum, including EWSR1-rearranged clear cell variant. generally aggressive largely unknown genetic features. A retrospective review Salivary Gland Tumor Registry in Pilsen searching for the key words "clear myoepithelial carcinoma," "hyalinizing cell," malignant myoepithelioma" yielded 94 carcinomas (CCMCs) molecular analysis EWSR1 rearrangement using fluorescence situ...
Salivary gland secretory carcinoma (SC), previously mammary analog SC, is a low-grade malignancy characterized by well-defined morphology and an immunohistochemical genetic profile identical to SC of the breast. Translocation t(12;15)(p13;q25) resulting in ETV6 :: NTRK3 gene fusion characteristic feature along with S100 protein mammaglobin immunopositivity. The spectrum alterations for continues evolve. aim this retrospective study was collect data salivary SCs correlate their histologic,...
Abstract Classification of head and neck tumors has evolved in recent decades including a widespread application molecular testing the salivary glands, sinonasal tract, oropharynx, nasopharynx, soft tissue. Availability new techniques allowed for definition multiple novel tumor types unique to sites. Moreover, expanding spectrum immunohistochemical markers facilitates rapid identification diagnostic abnormalities. As such, it is currently possible pathologists benefit from molecularly...
Sclerosing polycystic adenosis (SPA) is a recently described, rare lesion of the salivary glands that bears resemblance to epithelial proliferative lesions breast. The true nature unknown, but up now it has been generally believed represent pseudoneoplastic sclerosing and inflammatory process. However, local recurrence developed in about one-third cases. Superimposed dysplastic changes ranging from low-grade dysplasia carcinoma situ were described SPA. Although no metastases-related and/or...
To resolve the phylogeny of certain mitochondrial DNA (mtDNA) haplogroups in eastern Europe and estimate their evolutionary age, a total 73 samples representing U4, HV*, R1 were selected for complete genome sequencing from collection about 2,000 control region sequences sampled (Russians, Belorussians, Ukrainians) western (Poles, Czechs, Slovaks) Slavs. On basis whole-genome resolution, we fully characterized number (HV3, HV4, U4a1, U4a2, U4a3, U4b, U4c, U4d, R1a) that previously described...
The recurrent translocations t(11;19) and t(11;15) resulting in CRTC1-MAML2 or CRTC3-MAML2 fusion oncogenes, respectively, are identified a large proportion of mucoepidermoid carcinomas (MECs) the salivary gland have impact on prognosis. However, there conflicting data specificity this translocation, particular, its putative occurrence Warthin tumor (WT) parotid as reported few previous cases. It was speculated that extensive squamous metaplasia could explain presence translocation subset...