A5032820062- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Oral and Maxillofacial Pathology
- Cancer and Skin Lesions
- Tumors and Oncological Cases
- Head and Neck Surgical Oncology
- Head and Neck Cancer Studies
- Sarcoma Diagnosis and Treatment
- Soft tissue tumor case studies
- Neuroblastoma Research and Treatments
- Bone Tumor Diagnosis and Treatments
- Neuroendocrine Tumor Research Advances
- Breast Lesions and Carcinomas
- Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Salivary Gland Disorders and Functions
- Chromatin Remodeling and Cancer
- Hedgehog Signaling Pathway Studies
- Urologic and reproductive health conditions
- Vascular Tumors and Angiosarcomas
- Genetic factors in colorectal cancer
- Neurofibromatosis and Schwannoma Cases
- Lung Cancer Research Studies
- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
Charles University
2016-2025
Biopticka Laborator (Czechia)
2016-2025
International Union for Conservation of Nature
2018-2023
Johns Hopkins University
2019
University of Alabama at Birmingham
2019
Washington University in St. Louis
2019
Johns Hopkins Medicine
2019
Woodland Hills Medical Center
2018
University of Pittsburgh
2018
Universidade Estadual de Campinas (UNICAMP)
2018
We present a series of 16 salivary gland tumors with histomorphologic and immunohistochemical features reminiscent secretory carcinoma the breast. This is hitherto undescribed distinctive neoplasm, resembling both acinic cell (AciCC) low-grade cystadenocarcinoma, displaying strong similarities to breast carcinoma. Microscopically, have lobulated growth pattern are composed microcystic glandular spaces abundant eosinophilic homogenous or bubbly material positive for periodic acid-Schiff,...
Mammary analogue secretory carcinoma of salivary gland origin (MASC) is a recently described tumor resembling the breast characterized by strong S-100 protein, mammaglobin, and vimentin immunoexpression which harbors t(12;15) (p13;q25) translocation resulting in ETV6-NTRK3 fusion product. Histologically, conventional MASC displays bland histomorphology lobulated growth pattern often composed microcystic, tubular, solid structures with abundant eosinophilic homogenous or bubbly secretions....
ETV6 gene abnormalities are well described in tumor pathology. Many fusion partners of have been reported a variety epithelial and hematological malignancies. In salivary gland pathology, however, the ETV6-NTRK3 translocation is specific for mammary analogue secretory carcinoma (MASC), has not documented any other type. The present study comprised clinical molecular analysis 25 cases morphologically immunohistochemically typical MASC. They all also displayed rearrangement as visualized by...
•This ESMO–EURACAN Clinical Practice Guideline provides key recommendations for managing salivary gland cancer.•The guideline covers clinical and pathological diagnosis, staging risk assessment, treatment follow-up.•Treatment algorithms parotid, submandibular, sublingual minor cancer are provided.•The author group encompasses a multidisciplinary of experts from different institutions countries in Europe.•Recommendations based on available scientific data the authors' collective expert...
Mammary analog secretory carcinoma (MASC) is a recently described tumor predominantly arising in the parotid gland. These tumors represent locally invasive malignancies with microcystic architecture, low-grade nuclei, and granular pink vacuolated cytoplasm. They display strong vimentin S100 positivity harbor an identical t(12;15)(p13;q25) to their breast counterpart, leading ETV6-NTRK3 fusion oncogene. features help exclude most important differential diagnostic considerations, namely,...
ETV6 gene abnormalities are well described in tumor pathology. Many fusion partners of have been reported a variety epithelial, mesenchymal, and hematological malignancies. In salivary gland pathology, however, the ETV6-NTRK3 translocation is specific for (mammary analog) secretory carcinoma, has not documented any other type. The present study comprised clinical, histologic, molecular analysis 10 cases with typical morphology immunoprofile harboring novel ETV6-RET translocation.
Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumour that harbours the recurrent ETV6-NTRK3 translocation. This first series of MASC cases identified in historic cohort carcinomas glands with clinical/pathological correlation and follow-up data. We reviewed 183 primary major minor resected at Medical University Gdańsk, Poland, between 1992 2012. Based on morphology immunohistochemistry, suspicious for were selected, diagnosis was confirmed by fluorescence...
This study examines the presence of EWSR1 rearrangement in a variety clear cell salivary gland carcinomas with myoepithelial differentiation. A total 94 prominent component included 51 cases de novo (CCMC), 21 CCMCs ex pleomorphic adenoma (CCMCexPA), 11 epithelial-myoepithelial carcinoma (EMC), 6 EMC solid overgrowth, and 5 hyalinizing minor glands. In addition, 10 devoid change 12 benign myoepithelioma were as well. All tumors this spectrum reviewed, reclassified, tested by fluorescence...
Abstract Introduction Metastases to the brain from breast cancer have a high mortality, and basal-like cancers propensity for metastases. However, mechanisms that allow cells colonize are unclear. Methods We used morphology, immunohistochemistry, gene expression somatic mutation profiling analyze 39 matched pairs of primary metastases, 22 unmatched metastases cancer, 11 non-breast 6 autopsy cases patients with multiple sites, including brain. Results Most were triple negative . The...
Polymorphous low-grade adenocarcinoma (PLGA) and cribriform of minor salivary gland (CAMSG) are carcinomas arising most often in oral cavity oropharynx, respectively. Controversy exists as to whether these tumors represent separate entities or variants one spectrum, they appear have significant overlap, but also clinicopathologic differences. As many harbor recurrent translocations, paired-end RNA sequencing FusionSeq data analysis was applied for novel fusion discovery on two CAMSGs PLGAs....
We present a series of 23 cases distinctive, hitherto poorly recognized low-grade adenocarcinoma, with several histologic features reminiscent papillary carcinoma the thyroid, and which mostly but not exclusively occurs in tongue. All tumors were unencapsulated divided into lobules that composed mainly cribriform solid growth patterns. Therefore, we propose name "cribriform adenocarcinoma minor salivary gland origin (CAMSG)." patients adults mean age at diagnosis 55.8 years (range, 25 to 85...
Di Palma S, Simpson R H W, Marchiò C, Skálová A, Ungari M, Sandison Whitaker Parry S & Reis‐Filho J (2012) Histopathology 61, 629–643 Salivary duct carcinomas can be classified into luminal androgen receptor‐positive, HER2 and basal‐like phenotypes Aims: The aim of this study was to devise a molecular classification for salivary (SDCs) based on the similarities between SDCs breast characteristics microarray‐based gene expression profiling‐defined subtypes cancer. Methods results:...
Recently, we discovered the recurrent genomic rearrangement [t(4;9)(q13;q31)] enabling upregulation of transcription factor Nuclear Receptor Subfamily 4 Group A Member 3 (NR4A3) through enhancer hijacking as oncogenic driver event in acinic cell carcinoma (AciCC) salivary glands. In current study, evaluated usefulness NR4A3 immunostaining and fluorescence situ hybridization (FISH) differential diagnosis AciCC, comparing a total 64 AciCCs including 17% cases with high-grade transformation, 29...
We describe a novel gene fusion, EWSR1-CREM , identified in 3 cases of clear cell carcinoma (CCC) using anchored multiplex polymerase chain reaction, next-generation sequencing–based technique. CCC is low-grade salivary tumor recently characterized to have EWSR1-ATF1 fusions the majority cases. Three malignant presenting base tongue, lung, and nasopharynx were studied. All shared morphology with hyalinized stroma, presence mucin p63 positivity initially diagnosed as mucoepidermoid but...
Intraductal carcinoma (IC) is the new World Health Organization designation for tumors previously called "low-grade cribriform cystadenocarcinoma" and salivary duct carcinoma." The relationship of IC to controversial, but they now are considered be distinct entities. a rare low-grade malignant gland neoplasm with features similar mammary atypical ductal hyperplasia or in situ, that shows diffuse S100 protein mammaglobin positivity only partially defined genetically. (Mammary analogue)...
Intraductal carcinoma (IC) is the new WHO designation for tumors previously encompassed by "low-grade cribriform cystadenocarcinoma" and salivary duct carcinoma." The relationship of IC to (SDC) controversial, even though they are considered be distinct entities. a rare low-grade malignant gland neoplasm with histopathological features reminiscent atypical ductal hyperplasia or in situ breast, showing diffuse S100 protein mammaglobin positivity, while it partially defined genetically....
Background: Secretory carcinoma (SC), originally described as mammary analogue SC, is a predominantly low-grade salivary gland neoplasm characterized by recurrent t(12;15)(p13;q25) translocation, resulting in ETV6-NTRK3 gene fusion. Recently, alternative ETV6-RET , ETV6-MAML3 and ETV6-MET fusions have been found subset of SCs lacking the classic fusion transcript, but still harboring ETV6 rearrangements. Design: Forty-nine cases SC revealing typical histomorphology immunoprofile were...