A5033057223- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Head and Neck Surgical Oncology
- Head and Neck Cancer Studies
- Ear and Head Tumors
- Tracheal and airway disorders
- Sinusitis and nasal conditions
- Salivary Gland Disorders and Functions
- Head and Neck Anomalies
- Medical Practices and Rehabilitation
- Cancer and Skin Lesions
- Meningioma and schwannoma management
- Tumors and Oncological Cases
- Voice and Speech Disorders
- Oral and gingival health research
- Dysphagia Assessment and Management
- Radiomics and Machine Learning in Medical Imaging
- Pituitary Gland Disorders and Treatments
- Otolaryngology and Infectious Diseases
- Vascular Malformations and Hemangiomas
- Nasal Surgery and Airway Studies
- Glioma Diagnosis and Treatment
- Ear Surgery and Otitis Media
- Soft tissue tumor case studies
- Cancer Diagnosis and Treatment
University Hospital Augsburg
2016-2025
Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde
2020-2024
University Hospital Ulm
2024
University of Augsburg
2019-2023
Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde
1990-2021
Taipei Institute of Pathology
2019
Augsburg University
2018-2019
Johns Hopkins University
2014-2018
Friedrich-Alexander-Universität Erlangen-Nürnberg
2008-2017
University of Baltimore
2017
Abstract Objective: To evaluate the application of minimally invasive techniques in management salivary stones. Background: The incidence calculi is 60 cases/million/year, with most stones situated mid or proximal duct. current treatment these adenectomy. This paper reports results methods stone removal that avoid gland excision. Methods: Observational study 5,528 consecutive patients treated by lithotripsy, endoscopy, basket retrieval, and /or surgery five centers from 1990 to 2004...
Objective Sialendoscopy and other gland‐preserving techniques such as extracorporeal shockwave lithotripsy (ESWL), transoral stone removal, combinations of these methods have fundamentally changed the therapeutic approach to salivary stones. Since 2003, all patients presenting with sialolithiasis been diagnosed treated same algorithm routine gland endoscopy (SGE). Study Design Case series chart review between 2003 2008 using an for preservation. Setting Tertiary referral academic medical...
To determine the incidence of major and minor complications their impact on patients' comfort after parotid surgery in benign disease.Retrospective.Four hundred ninety-two patients were included. Total parotidectomy (TP) was performed 65.8%, superficial (SP) 27.2%, partial (PSP) 7.0%. Patients interviewed using a self-designed questionnaire. Incidence evaluated depending extent intensity complaints. ascertain morbidity daily lives, asked to estimate it according visual analog scale.Frey's...
In mice, conventional and plasmacytoid dendritic cells (DCs) derive from separate hematopoietic precursors before they migrate to peripheral tissues. Moreover, two classes of DCs (cDC1 cDC2 DCs) one class (pDCs) have been shown be transcriptionally functionally distinct entities. humans, these three DC subtypes can identified using the cell surface markers CD1c (cDC2), CD141 (cDC1), CD303 (pDCs), albeit it remains elusive whether functionality is mainly determined by ontogeny or tissue...
The desirable extent of surgical intervention for benign parotid tumors remains a matter controversy. Superficial or total parotidectomy as standard procedure is often said to be the gold standard; however, with it risk intraoperative damage facial nerve cannot ignored. For some time now, extracapsular dissection without exposure main trunk has been favored an alternative treatment discrete tumors. Data on incidence lesions and other acute postoperative complications have lacking until...
To investigate epidemiological features and symptoms of sialolithiasis their implications for diagnosis management.Retrospective cohort study.Retrospective analysis on 2,322 patients with sialolithiasis, between 1987 2009. The statistical significance two sample distributions was computed using variance Student t test two-tailed distribution.A total 2,959 calculi were identified by means ultrasound. Of those, 80.4% located in the submandibular duct system (53% hilar/proximal, 37% distal, 10%...
The ideal extent of surgical intervention for benign parotid tumors remains a matter controversy. aim the study was to trace development therapy in large cohort, explore its changes single institution specializing salivary gland pathologies over last 12 years, and determine which possible shift toward less radical methods correlated with change incidence facial palsy Frey's syndrome.Retrospective clinical study.A retrospective evaluation records all patients treated between 2000 2012 at...
Recently, we discovered the recurrent genomic rearrangement [t(4;9)(q13;q31)] enabling upregulation of transcription factor Nuclear Receptor Subfamily 4 Group A Member 3 (NR4A3) through enhancer hijacking as oncogenic driver event in acinic cell carcinoma (AciCC) salivary glands. In current study, evaluated usefulness NR4A3 immunostaining and fluorescence situ hybridization (FISH) differential diagnosis AciCC, comparing a total 64 AciCCs including 17% cases with high-grade transformation, 29...
Objective The coronavirus disease 2019 (COVID‐19) pandemic has led to a global surge in critically ill patients requiring invasive mechanical ventilation, some of whom may benefit from tracheostomy. Decisions on if, when, and how perform tracheostomy with COVID‐19 have major implications for patients, clinicians, hospitals. We investigated the protocols practices that institutions around world put into place response pandemic. Data Sources Protocols severe acute respiratory syndrome 2...
To assess transoral treatment of submandibular lithiasis.Study a series patients with stones undergoing removal the sialoliths. Duration follow-up: 6 months to 7 years.Department Otorhinolaryngology, Head and Neck Surgery, University Erlangen-Nuremberg, Erlangen, Germany, center for salivary stones.Two hundred thirty-one (127 females, 104 males) suffering from lithiasis had mean age 41.7 years (age range, 12-86 years). Stone location was distal edge mylohyoid muscle in 115 proximal gland 102...
To correlate World Health Organization (WHO) grade, patient's outcome and presence of t(11;19) to histological tumour variants in 40 well-characterized mucoepidermoid carcinomas (MECs).MECs were classified as 'classical' based on the equal proportions three cell types or dominance (≥50%) mucous cells together with at least one other type, 'variant' if composed ≥80% a single non-mucous type. Classical MECs more common (n=23). Variant had predominant squamoid (n=9), eosinophilic (n=5) clear...
Leptin is produced predominantly in adipose tissue but has recently also been found gastric mucosa. It shown that the oral application of leptin induces neuronal activity brain stem rodents. The objective present study was to identify this hormone human saliva and examine production stability salivary leptin. We have demonstrated glands mucosa by RT-PCR, its storage immunocytochemistry, release peptide RIA. Chromatographic analysis immunoblotting confirmed identity There a strong linear...
OBJECTIVE Sialoscopy has developed into an important diagnostic and therapeutic tool for diseases of the major salivary glands. STUDY DESIGN AND SETTING We evaluated 103 patients with chronic swelling Routine measures revealed no clear diagnosis. The findings 109 sialoscopies are described. A semi‐rigid endoscope (with a diameter 1.1 mm 2 integrated working channels) was used sialoscopy, 51.5% cases in Warthon's duct 48.5% Stensen's duct. RESULTS Pathologic resulted 83.0% submandibular 96%...
We investigated whether ghrelin is present in human saliva, produced by salivary glands, and physiologic consequences of these findings.Expression specific receptor mRNA was determined PCR. Proteins were identified immunoblotting size-exclusion fast protein liquid chromatography (FPLC) with consecutive RIA. Specific RIAs used for quantification total bioactive ghrelin. Distribution immunohistochemistry cryosections the glands. The effect on incorporation 5-bromo-2'-deoxyuridine as a measure...
Abstract Background Comparison of the diagnostic validity positron emission tomography (PET) alone with integrated PET and CT (PET/CT) in search for occult primary tumors patients cancer unknown (CUP) site head neck. Methods Thirty‐nine consecutive clinical CUP were investigated 38 PET/CT. After initial panendoscopy histological confirmation cervical lymph node metastasis, either or PET/CT scanning was performed. Results Integrated had a significantly higher overall detection rate than...