A5039660972- Sarcoma Diagnosis and Treatment
- Soft tissue tumor case studies
- Salivary Gland Tumors Diagnosis and Treatment
- Renal cell carcinoma treatment
- Cancer and Skin Lesions
- Tumors and Oncological Cases
- Urologic and reproductive health conditions
- Oral and Maxillofacial Pathology
- Renal and related cancers
- Bone Tumor Diagnosis and Treatments
- Cancer Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Soft tissue tumors and treatment
- Neurofibromatosis and Schwannoma Cases
- Ear and Head Tumors
- Medical Imaging and Pathology Studies
- Testicular diseases and treatments
- Histiocytic Disorders and Treatments
- Cardiac tumors and thrombi
- Uterine Myomas and Treatments
- Head and Neck Anomalies
- Metastasis and carcinoma case studies
- Urinary and Genital Oncology Studies
- Cancer Genomics and Diagnostics
- Thyroid Cancer Diagnosis and Treatment
Charles University
2016-2025
Biopticka Laborator (Czechia)
2016-2025
University Hospital Plzen
2008-2025
Moffitt Cancer Center
2019
Mount Sinai Hospital
2019
Institute of Electrical and Electronics Engineers
2017-2018
Canadian Standards Association
2017-2018
Pilsen Tools (Czechia)
2017
Fakultní nemocnice Bulovka
2016
St Petersburg University
2016
ETV6 gene abnormalities are well described in tumor pathology. Many fusion partners of have been reported a variety epithelial, mesenchymal, and hematological malignancies. In salivary gland pathology, however, the ETV6-NTRK3 translocation is specific for (mammary analog) secretory carcinoma, has not documented any other type. The present study comprised clinical, histologic, molecular analysis 10 cases with typical morphology immunoprofile harboring novel ETV6-RET translocation.
Phosphaturic mesenchymal tumor (PMT) is a rare neoplasm of uncertain histogenesis that has been linked to tumor-induced osteomalacia (TIO) since 1959. The neoplastic cells produce increased amount FGF23 which results in TIO via uncontrolled renal loss phosphate (phosphaturia), and consequently diminished bone mineralization. To date, ∼300 cases have reported. Although there increasing evidence PMT can be diagnosed by reproducible histopathologic features, firm diagnosis often restricted...
Background: Secretory carcinoma (SC), originally described as mammary analogue SC, is a predominantly low-grade salivary gland neoplasm characterized by recurrent t(12;15)(p13;q25) translocation, resulting in ETV6-NTRK3 gene fusion. Recently, alternative ETV6-RET , ETV6-MAML3 and ETV6-MET fusions have been found subset of SCs lacking the classic fusion transcript, but still harboring ETV6 rearrangements. Design: Forty-nine cases SC revealing typical histomorphology immunoprofile were...
Abstract Alterations in kinase genes such as NTRK1/2/3 , RET and BRAF underlie infantile fibrosarcoma (IFS), the emerging entity ‘ NTRK ‐rearranged spindle cell neoplasms’ included latest WHO classification, a growing set of tumors with overlapping clinical pathological features. In this study, we conducted comprehensive clinicopathological molecular analysis 22 cases IFS other gene‐altered neoplasms affecting both pediatric adult patients. Follow‐up periods for 16 patients ranged length...
GLI1 -altered mesenchymal tumor is a recently described distinct pathologic entity with an established risk of malignancy, being defined molecularly by either gene fusions or amplifications. The clinicopathologic overlap tumors driven the 2 seemingly mechanisms activation still emerging. Herein, we report largest series confirmed neoplasms to date, including 23 GLI1- amplified and 15 -rearranged new cases, perform comparative clinicopathologic, genomic, survival investigation. rearranged...
Vascular neoplasms with epithelioid cytomorphology encompass a wide spectrum of benign and malignant lesions, including hemangioma (EH), cutaneous angiomatous nodule (CEAN), hemangioendothelioma (EHE), angiosarcoma (EAS). Recently, the first case features harboring TPM3::ALK fusion was reported. Herein, we report 4 additional cases, 1 an alternate TPM4::ALK fusion, expand on clinicopathologic molecular genetic these unusual vascular lesions. Including previously reported case, 5 tumors...
Infantile myofibroma (MF) is an uncommon benign myofibroblastic tumor of infancy and childhood. Solitary adult MF shares similar features with infantile MF. The lesions occur in 3 clinicopathologic settings: solitary, multicentric, generalized can be either sporadic or familial. Traditionally, has been included the spectrum hemangiopericytoma. recent World Health Organization classification listed MF, angioleiomyoma, myopericytoma under general heading perivascular tumors sense a morphologic...
Abstract Classification of head and neck tumors has evolved in recent decades including a widespread application molecular testing the salivary glands, sinonasal tract, oropharynx, nasopharynx, soft tissue. Availability new techniques allowed for definition multiple novel tumor types unique to sites. Moreover, expanding spectrum immunohistochemical markers facilitates rapid identification diagnostic abnormalities. As such, it is currently possible pathologists benefit from molecularly...
The Clinco-pathological, immunohistochemical and molecular findings of four cases Mammary Analogue Secretory Carcinoma (MASC) salivary glands found in Mexico are described. were extracted from 253 gland tumors a single institution City. 85 Candidates for initial selection were: low grade mucoepidermoid carcinoma (MEC) (N=70 ), Acinic cell cancinoma (AciCC) (N=14), papillary cystadenocarcinoma (N=1), adenocarcinoma NOS (N=0). Tumors with some histological features consistent MASC (N= 17,...
Littoral cell angioma (LCA) is a rare primary splenic tumour that frequently associated with internal malignancies. Immunohistochemistry can demonstrate distinct hybrid endothelial-histiocytic phenotype of littoral cells, and helpful adjunct for making the correct diagnosis. The aims this study were to present series 25 LCAs, an emphasis on frequent association neoplasm visceral malignancies, provide detailed immunohistochemical analysis by employing new markers.All cases available tissue...
Superficial CD34-positive fibroblastic tumor (SCD34FT) and PRDM10-rearranged soft tissue (PRDM10-STT) are rare mesenchymal tumors. These lesions have clinicopathological similarities, but their relationship remains controversial. This study aimed to characterise a series of cases SCD34FT PRDM10-STT.Ten each PRDM10-STT were studied using immunohistochemistry, array-comparative genomic hybridisation (aCGH), RNA sequencing exome sequencing. Tumors mainly occurred in young adults, generally...
Giant cell tumors of soft tissue (GCT-ST) are rare low-grade neoplasms that were at one time thought to represent the counterparts GCT bone (GCT-B) but now known lack H3F3 mutations characteristic osseous GCT. We present six distinctive giant cell-rich expressed keratins and carried a recurrent HMGA2-NCOR2 gene fusion. Patients five females male aged 14-60 years (median, 29). All presented with superficial (subcutaneous) masses removed by conservative marginal (3) or wide (2) local excision....
Clear cell (hemangioblastoma-like) stromal tumor of the lung (CCST-L) is a recently described distinctive rare pulmonary neoplasm unknown histogenesis and molecular pathogenesis. Only 7 cases have been reported in 2 recent studies, although additional might under heading extraneural hemangioblastoma. We herein describe 4 CCST-L cases, 3 them harboring YAP1-TFE3 fusion. The fusion-positive tumors occurred women, aged 29, 56, 69 years. All presented with solitary nodules measuring 2.3 to 9.5...
Calcified chondroid mesenchymal neoplasm is a term proposed for tumors with spectrum of morphologic features, including cartilage/chondroid matrix formation, that frequently harbor FN1 gene fusions. We report series 33 cases putative calcified neoplasms, mostly referred expert consultation out concern malignancy. Patients included 17 males and 16 females, mean age 51.3 years. Anatomic locations include the hands fingers, feet toes, head neck, temporomandibular joint; 1 patient presented...
Despite significant advances in their molecular pathogenesis, skeletal vascular tumors remain diagnostically challenging due to aggressive radiologic appearance and morphologic overlap. Within the epithelioid category at benign end of spectrum, recurrent FOS/FOSB fusions have defined most hemangiomas, distinguishing them from hemangioendothelioma angiosarcoma. More recently, presence EWSR1/FUS :: NFATC1/2 emerged as genetic hallmark a novel group unusual proliferations, often displaying...
Abstract With the increasing use of innovative next generation sequencing (NGS) platforms in routine diagnostic and research settings, genetic landscape uterine sarcomas has been dynamically evolving during last two decades. Notably, majority recently recognized genotypes represent gene fusions, while recurrent oncogene mutations and/ or therapeutic value have rare. Recently, a distinctive aggressive sarcoma expressing S100 SOX10, but otherwise lacking morphological, immunophenotypic...
Aims: We present the largest series of an unclassified subtype renal cell carcinoma, which seems to be a distinct morphological entity and is sometimes designated as spindle cuboidal carcinoma. Methods results: Eleven cases carcinoma were found among 7000 primary tumours in Pilsen's routine consultation files. The patients five men six women. They ranged age from 22 65 years (mean 56.8). Microscopically, composed two main populations cells. First, preponderant type cells was formed by...
Previous reports of monomorphic clear cell carcinoma the salivary glands have shown inconsistent results with immunohistochemistry, especially for S-100 protein, and this has led to uncertainty about nature these tumours. We believe that much can be explained by considering group as comprising not one but two separate neoplasms, epithelial other myoepithelial. The former been described hyalinizing carcinoma--it generally occurs in minor glands, strongly expresses cytokeratins protein or...