A5065108026- Oral and Maxillofacial Pathology
- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Bone Tumor Diagnosis and Treatments
- Tumors and Oncological Cases
- dental development and anomalies
- Oral Health Pathology and Treatment
- Periodontal Regeneration and Treatments
- Cancer and Skin Lesions
- Soft tissue tumor case studies
- Cancer Diagnosis and Treatment
- Oral and gingival health research
- Vascular Malformations and Hemangiomas
- Head and Neck Surgical Oncology
- Protease and Inhibitor Mechanisms
- Bone health and treatments
- Neurofibromatosis and Schwannoma Cases
- Peptidase Inhibition and Analysis
- Genital Health and Disease
- Urological Disorders and Treatments
- Bone Tissue Engineering Materials
- Hedgehog Signaling Pathway Studies
- Teratomas and Epidermoid Cysts
- Mesenchymal stem cell research
- Sarcoma Diagnosis and Treatment
Faculdade São Leopoldo Mandic
2015-2024
Universidade Federal do Tocantins
2014-2024
University of Helsinki
2009-2015
Helsinki University Hospital
2008-2010
Biopticka Laborator (Czechia)
2010
Universidade de São Paulo
2005
We present a series of 16 salivary gland tumors with histomorphologic and immunohistochemical features reminiscent secretory carcinoma the breast. This is hitherto undescribed distinctive neoplasm, resembling both acinic cell (AciCC) low-grade cystadenocarcinoma, displaying strong similarities to breast carcinoma. Microscopically, have lobulated growth pattern are composed microcystic glandular spaces abundant eosinophilic homogenous or bubbly material positive for periodic acid-Schiff,...
High-grade transformation of acinic cell carcinoma (AciCC) (previously referred to as dedifferentiation) is a rare phenomenon characterized by histologic progression low-grade AciCC high-grade adenocarcinoma or undifferentiated carcinoma. We report 9 new cases with immunohistochemical analysis and examination HER-2/neu p53 genes further define the profile this tumor. Histologically, component was composed polymorphic cells high mitotic rate arranged in glandular solid growth patterns...
Conclusions: Metastatic disease should always be considered as a potential differential diagnosis in the adult patient with cystic neck lesion. Objectives: The most common cause of lesion young adults is branchial cleft cyst (BCC). In older patients metastatic lymph nodes may easily misdiagnosed BCC. This study aimed to investigate incidence unsuspected carcinoma routinely excised cervical cysts at tertiary care teaching hospital and determine characteristics benign BCC malignancy...
J Oral Pathol Med (2012) 41 : 394–399 Background: tongue squamous cell carcinoma (OTSCC) often metastasizes to cervical lymph nodes. Mechanisms of this disease progression are not fully known. We aimed at finding new predictive markers for diagnosis and monitoring. Methods: Seventy‐three consecutive T1N0M0 T2N0M0 OTSCC patients treated Helsinki University Central Hospital, Helsinki, Finland, in 1992–2002 were included. Tissue array blocks prepared from primary tumors immunostained....
Establishing the risk of malignant transformation (MT) in oral leukoplakia is usually based on grading epithelial dysplasia (OED) biopsy tissue, for which two systems are proposed: a 3-tier and binary system. Only very few actuarial studies have tested accuracy such methods predicting MT, especially This study aimed to assess MT cohort (OL) from Brazil, with follow-up data.The sample comprised 878 individuals diagnosed OL 2005 2018. Follow-up data were obtained both locally regional cancer...
The peripheral giant cell granuloma (PGCG) is a nonneoplastic lesion commonly caused by local irritation. This report describes 46-year-old Caucasian male who presented with PGCG associated dental implant. implant was originally placed in August 2012. Ten months later, the patient well-circumscribed and covering implant, at which time excised. Four due to recurrence of lesion, deeper wider excisional biopsy curettage adjacent bone performed. No evidence has been reported after 12 follow-up....
Objectives To integrate mRNA and miRNA expression profiles of mucoepidermoid carcinomas (MECs) normal salivary gland (NSGs) tissue samples identify potential drivers. Material Methods Gene arrays were performed in 35 MECs six NSGs. Results We found 46 differentially expressed (DE) miRNAs 3,162 DE mRNAs. Supervised hierarchical clustering analysis the transcripts revealed two clusters both profiles, which distinguished MEC from NSG samples. The integrative miRNA-mRNA a network comprising 696...
Predicting the clinical course of early-stage oral tongue squamous cell carcinoma (SCC) is challenging. As matrix metalloproteinases (MMPs) are enzymes associated with invasion, metastasis, and poor survival in many cancers, we examined MMP-7 MMP-25 SCC.We used tissue microarray (TMA) technique immunohistochemistry to study expression 73 patients stage I II SCC compared their immunoexpressions data.Immunohistochemistry revealed 90% (n = 63 70) 64 71) tumors, respectively. protein was...
Abstract Background Adenoid cystic carcinoma (AdCC) and polymorphous adenocarcinoma (PAC) are included among the most common salivary gland cancers. They share clinical histological characteristics, making their diagnosis challenging in specific cases. MicroRNAs (miRNA) short, non‐coding RNA sequences of 19‐25 nucleotides length that involved post‐transcriptional protein expression. have been shown to play important roles neoplastic non‐neoplastic processes suggested as diagnostic prognostic...
Congenital granular cell epulis is a rare benign soft tissue lesion arising from the alveolar ridge in neonates. A case of multiple congenital reported, alongside description its vascular immunohistochemical profile. female newborn presented with two exophytic pedunculated red nodules located on between future eruption sites incisors and canines mandible maxilla. conservative surgical excision was performed second day life. Histology revealed proliferation round cells containing an abundant...
Conclusion: Difficulties in diagnosis, conservative initial steps the management algorithm and intraoperative risks for facial nerve (FN) injury are divisive features this tumour entity. Objective: The aim of present study was to investigate outcome FN schwannomas (FNSs) at a tertiary referral centre academic institution 30-year material. Methods: Data on age, sex, symptoms, location, histopathological characteristics, imaging, were retrospectively recorded. Results: Ten cases (six males,...
Brown tumors are giant cell-rich lesions that result from abnormal bone metabolism in hyperparathyroidism, one of the most common endocrine disorders worldwide. occasionally affect jaws and, despite well-known clinical and microscopic features, their molecular pathogenesis remains unclear. We investigated presence pathogenic activating mutations TRPV4, FGFR1, KRAS a cohort brown since these have recently been reported giant-cell non-ossifying fibromas bones (FGFR1 KRAS), which histologic...
Neutrophils have been implicated in granuloma formation several infectious diseases, addition to their main phagocytic and pathogen destruction role. It has demonstrated that Nrf2 regulates antioxidant protection neutrophils, attenuating inflammation without compromising the hosts bacterial defense. In this study, we analyzed presence of neutrophils Paracoccidioides brasiliensis mycosis (PCM), as well immunoexpression Nrf2. Thirty-nine cases oral PCM were classified according quantity fungi...
The present study aimed to compare the expression of p63/p40 with smooth muscle actin (SMA) and vimentin (VIM) by myoepithelial cells in minor salivary gland tumors. Fifty-two formalin-fixed paraffin-embedded samples tumors derived from intercalated duct (pleomorphic adenoma [PA], adenoid cystic carcinoma [ACC], epithelial-myoepithelial [EMC], polymorphous adenocarcinoma [PAC], secretory [SC]) 3 excretory (mucoepidermoid [MEC]) were evaluated means immunohistochemistry. data analyzed...