A5059251523- Pain Mechanisms and Treatments
- Inflammatory mediators and NSAID effects
- Neuropeptides and Animal Physiology
- Oral microbiology and periodontitis research
- Peroxisome Proliferator-Activated Receptors
- Temporomandibular Joint Disorders
- Botulinum Toxin and Related Neurological Disorders
- Eicosanoids and Hypertension Pharmacology
- Adenosine and Purinergic Signaling
- Bone Metabolism and Diseases
- Dental Implant Techniques and Outcomes
- Orthodontics and Dentofacial Orthopedics
- Salivary Gland Disorders and Functions
- NF-κB Signaling Pathways
- Cell Adhesion Molecules Research
- Pharmacological Effects of Natural Compounds
- Advancements in Transdermal Drug Delivery
- Bone health and treatments
- Macrophage Migration Inhibitory Factor
- Endodontics and Root Canal Treatments
- Olfactory and Sensory Function Studies
- Dental materials and restorations
- Neuroinflammation and Neurodegeneration Mechanisms
- Laser Applications in Dentistry and Medicine
- Osteoarthritis Treatment and Mechanisms
Faculdade São Leopoldo Mandic
2017-2024
Interface (United States)
2023
Universidade Estadual de Campinas (UNICAMP)
2011-2020
Pontifícia Universidade Católica de Campinas
2020
Texas Tech University
2019
Institute of Neuroimmunology of the Slovak Academy of Sciences
2019
Interface (United Kingdom)
2019
Universidade de Uberaba
2006-2012
American Association of Endodontists
2010
MRC Laboratory of Molecular Biology
2009
Bones are widely innervated, suggesting an important role for the sympathetic regulation of bone metabolism, although there controversial studies. We investigated effects propranolol in a model experimental periodontal disease.Rats were assigned as follows: animals without ligature; ligated receiving vehicle and 0.1, 5 or 20 mg·kg(-1) propranolol. After 30 days, haemodynamic parameters measured by cardiac catheterization. Gingival tissues removed assessed IL-1β, TNF-α cross-linked...
Abstract Inflammatory conditions of the temporomandibular joint (TMJ) and peripheral tissues affect many people around world are commonly treated with non-steroidal anti-inflammatory drugs (NSAIDs). However, in order to get desirable results, treatments NSAIDs may take weeks, causing undesirable side effects requiring repeated administration. In this sense, work describes development an optimized nanostructured lipid carrier (NLC) formulation for intra-articular administration naproxen...
Natural or synthetic ligands for peroxisome proliferator-activated receptor gamma (PPAR-γ) represent an interesting tool pharmacological interventions to treat inflammatory conditions. In particular, PPAR-γ activation prevents pain and inflammation in the temporomandibular joint (TMJ) by decreasing cytokine release stimulating synthesis of endogenous opioids. The goal this study was clarify whether induces macrophage polarization, inhibiting leukocyte recruitment. addition, we investigated...
Periodontitis is a disease that leads to bone destruction and represents the main cause of tooth loss in adults. The development aggressive periodontitis has been associated with increased inflammatory response induced by presence subgingival biofilm containing Aggregatibacter actinomycetemcomitans. flavonoid quercetin (1) widespread vegetables fruits exhibits many biological properties for possible medical clinical applications such as its anti-inflamatory antioxidant effects. Thus, present...
The bark of Mimosa tenuiflora (Willd.) Poiret (Leguminosae family), popularly known as "jurema preta" in Brazil, is used by the population Contendas Sincorá (Bahia State, Brazil) for treatment coughs and wound healing. Thus, aim this study was to evaluate antinociceptive anti-inflammatory activities ethanol extract (EEMT) solvent soluble fractions (hexane—H, DCM—D, EtOAc—E BuOH—B) vivo. Additionally, we synthesized 5,7-dihidroxy-4'-methoxyflavanone (isosakuranetin) isolated compound...
The 15-deoxy-Δ<sup>12,14</sup>-prostaglandin J<sub>2</sub> (15d-PGJ<sub>2</sub>) is an endogenous ligand of peroxisome proliferator-activated receptors γ (PPAR-γ) and now recognized as a potent anti-inflammatory mediator. However, information regarding the influence 15d-PGJ<sub>2</sub> on inflammatory pain still unknown. In this study, we evaluated effect upon hypernociception mechanisms involved in effect. We observed that intraplantar administration (30–300 ng/paw) inhibits mechanical...
The objective of this study was to assess the effects oral ingestion β-glucans isolated from Saccharomyces cereviseae on metabolic profile, expression gingival inflammatory markers and amount alveolar bone loss in diabetic rats with periodontal disease. Diabetes mellitus induced 48 Wistar by intraperitoneal injection streptozotocin (80 mg/kg). After confirming diabetes diagnosis, animals were treated (by gavage) for 28 days. On 14th day period, disease using a ligature protocol. reduced both...
Abstract Gout arthritis (GA) is a painful inflammatory disease in response to monosodium urate (MSU) crystals the joints. 15deoxy-Δ 12,14 -prostaglandin J 2 (15d-PGJ ) natural activator of PPAR-γ with analgesic, anti-inflammatory, and pro-resolution properties. Thus, we aimed evaluate effect mechanisms action 15d-PGJ nanocapsules (NC) model GA mice, since reduction 33-fold dose has been reported. Mice were treated -loaded NC, inert free (without NC), or NC+ GW9662, inhibitor. We show that NC...
Background and Purpose Epoxyeicosatrienoic acids (EETs) other epoxy fatty (EpFA) are lipid mediators that rapidly inactivated by soluble epoxide hydrolase (sEH). Uncontrolled chronic inflammatory disorders fail to sufficiently activate endogenous regulatory pathways, including the production of specialized pro‐resolving (SPMs). Here, we addressed relationship between SPMs EET/sEH axis explored effects sEH inhibition on resolving macrophage phenotype. Experimental Approach Mice were treated...
Abstract We have recently demonstrated that gonadal steroid hormones decrease formalin‐induced temporomandibular joint nociception in rats. Given the attenuation of inflammation is a potential mechanism underlying this antinociceptive effect, we evaluated effect on inflammation. Plasma extravasation, major sign acute inflammation, and neutrophil migration, an important event related to tissue injury, were evaluated. Formalin induced significantly lower plasma extravasation migration...
To verify whether the nanoencapsulation of 15d-PGJ(2) in poly(D,L-lactide-co-glycolide) (PLGA) nanocapsules (15d-PGJ(2)-NC) might potentialize its antinociceptive activity into rats' temporomandibular joint (TMJ).Transmission electron microscopy (TEM) and atomic force (AFM) were used to evaluate morphology suspension PLGA nanocapsules. Rats pretreated (15 min) with an intra-TMJ injection unloaded or 15d-PGJ(2)-NC at concentrations 10, 100 1000 pg followed by ipsilateral 1.5% formalin. The...