Abstract Objectives: The aim of this study was to evaluate the clinical and microbiological effects mechanical anti‐infective therapies for mucositis peri‐implantitis. Material methods: Subjects with at least one dental implant were assigned healthy ( n =10), =12) or peri‐implantitis =13) groups. Implants decontaminated by means teflon curettes abrasive sodium carbonate air‐powder, performed an open flap without surgery mucositis. Visible plaque (PI), marginal bleeding (MB), on probing...

The microbial profile of localized aggressive periodontitis (LAgP) has not yet been determined. Therefore, the aim this study was to evaluate subgingival composition LAgP.One hundred and twenty subjects with LAgP (n=15), generalized (GAgP, n=25), chronic (ChP, n=30) or periodontal health (PH, n=50) underwent clinical microbiological assessment. Nine plaque samples were collected from each subject analysed for their content 38 bacterial species using checkerboard DNA-DNA hybridization.Red...

Mestnik MJ, Feres M, Figueiredo LC, Duarte PM, Lira EAG, Faveri M. Short‐term benefits of the adjunctive use metronidazole plus amoxicillin in microbial profile and clinical parameters subjects with generalized aggressive periodontitis. J Clin Periodontol 2010; 37: 353–365. doi: 10.1111/j.1600‐051X.2010.01538.x Abstract Aim: The aim this study was to evaluate microbiological effects scaling root planing (SRP) alone or combined (MTZ) (AMX) treatment periodontitis (GAgP). Materials Methods: A...

Background: The aim of this study is to evaluate the local and circulating levels adipocytokines (resistin, adiponectin, leptin, tumor necrosis factor [TNF]‐α, interleukin [IL]‐6) in individuals who are obese normal weight (NW) with chronic periodontitis (CP). Methods: Periodontal anthropometric examinations were performed. Based on these measurements, divided into one following groups: NW non‐periodontitis (NP) (NWNP; n = 20); NWCP (n NP (ONP; 18); CP (OCP; 20). evaluated serum gingival...

Background: This study compares the levels of cytokines and bone‐related factors in gingival crevicular fluid (GCF) systemically healthy patients with chronic periodontitis (CP); better‐controlled, poorly controlled type 2 diabetes CP. Methods: Thirty‐seven CP 20 were enrolled this study. The mellitus categorized as better‐controlled (n = 17; HbA 1c ≤8%) or 20; glycated hemoglobin values >8%). Levels tumor necrosis factor‐α, interleukin (IL)‐4, interferon (IFN)‐γ, IL‐23, IL‐17, soluble...

To evaluate whether obesity affects the subgingival microbial composition of patients with periodontal health or chronic periodontitis (CP).Based on parameters, body mass index and waist-hip ratio, 166 were allocated into one following groups: Normal weight (NW) (n = 44), NW CP 40), obese 40) 42). Six biofilm samples per patient analysed for their content 40 bacterial species using checkerboard DNA-DNA hybridization.Obese harboured higher levels and/or proportions several pathogens than...

Background: The objectives of this study were to clinically and immunologically assess the effects mechanical anti‐infective therapies for mucositis peri‐implantitis compare levels cytokines in untreated treated peri‐implant diseased sites healthy ones. Methods: Titanium dental implants assigned one following groups: (n = 10) control; debridement using abrasive sodium carbonate air‐powder resin curets; 20) open surgical curets. Visible plaque accumulation, marginal bleeding, bleeding on...

The emergence of periodontal medicine has increased interest in defining the serologic profiles inflammatory mediators subjects with periodontitis. Thus, aim this pilot study is to evaluate serum levels tumor necrosis factor-alpha (TNF-alpha), interferon-gamma, and interleukin (IL)-4, -17, -23 generalized chronic periodontitis (GCP) aggressive (GAgP) before after non-surgical therapy.Cytokines were measured by enzyme-linked immunosorbent assay samples taken from 42 systemically healthy...

Background: Newly formed biofilm after implant debridement may challenge the long‐term stability of peri‐implant therapy. This in vitro study aimed to assess roughness and adherence Streptococcus sanguinis treatment smooth rough titanium surfaces with an erbium‐doped:yttrium, aluminum, garnet (Er:YAG) laser, metal plastic curets, air‐powder abrasive system. Methods: Forty disks smooth‐machined 40 sand‐blasted acid‐etched were divided into following groups: Er:YAG laser; curet; curet, The...

This study assessed gene expression by quantitative polymerase chain reaction of inflammatory- [interleukin (IL)-12, tumor necrosis factor-alpha (TNF-alpha), IL-4, and IL-10] osteoclastogenesis-related factors [receptor activator NF-kappaB ligand (RANKL) osteoprotegerin (OPG)] in sites exhibiting different severities peri-implant disease.Peri-implant soft tissue biopsies (n=48) were harvested from healthy implant (HI), mucositis (MC), initial peri-implantitis (IP) severe (SP) sites.IL-12...

This study tested the hypotheses that there is: (1) higher bacterial frequency in peri-implantitis/periodontitis, followed by mucositis/gingivitis and peri-implant/periodontal health; (2) similar between comparable peri-implant periodontal clinical statuses. The presence of Porphyromonas gingivalis, Tannerella forsythia, Campylobacter rectus, Prevotella intermedia, Treponema denticola Aggregatibacter actinomycetemcomitans was evaluated (n = 53) mucositis 50), gingivitis peri-implantitis 50)...

To evaluate the effects of systemic azithromycin (AZM) as an adjunct to scaling and root planing (SRP) in treatment generalized chronic periodontitis (ChP).Forty subjects were randomly assigned receive SRP alone or combined with AZM (500 mg/day) for 5 days (n=20/group). Clinical microbiological examinations performed at baseline, 6 months 1-year post-SRP. Nine plaque samples per subject analysed by checkerboard DNA-DNA hybridization 40 bacterial species. Differences between groups assessed...

Background: Excessive gingival display (EGD) has a negative impact on pleasant smile. Minimally invasive therapeutic modalities have become the standard treatment in many dentistry fields. Therefore, aim of this study is to compare clinical outcomes open‐flap (OF) and minimally flapless (FL) esthetic crown lengthening (ECL) for EGD. Methods: A split‐mouth randomized controlled trial was conducted 28 patients presenting with Contralateral quadrants received ECL using OF or FL techniques....

To evaluate the clinical effects of adjunctive use metronidazole (MTZ) and amoxicillin (AMX) in treatment generalized aggressive periodontitis (GAgP).Thirty subjects were randomly assigned to receive scaling root planing (SRP) alone or combined with MTZ (400 mg/TID) AMX (500 for 14 days. Subjects clinically monitored at baseline, 6 months 1 year post-therapies.Both therapies led a statistically significant improvement all parameters post-therapy (p < 0.05). receiving plus exhibited deepest...

This study evaluated the effects of scaling and root planing (SRP) on gingival crevicular fluid (GCF) serum levels adipokines in patients with chronic periodontitis (CP) or without obesity.Twenty obesity 20 obesity, all CP, received SRP. Serum GCF resistin, adiponectin, leptin, tumour necrosis factor [TNF]-α interleukin [IL]-6 were by enzyme-linked immunosorbent assay at baseline, 3, 6 12 months post-therapy.SRP reduced amounts TNF-α deep sites increased concentration adiponectin shallow...

To evaluate the clinical and microbiological effects of use metronidazole (MTZ) + amoxicillin (AMX) as adjuncts to scaling root planing (SRP) for treatment chronic periodontitis (ChP) in type 2 diabetic subjects.Fifty-eight subjects (n = 29/group) with generalized ChP were randomly assigned receive SRP alone or MTZ [400 mg/thrice a day (TID)]+AMX (500 mg/TID) 14 days. Subgingival biofilm samples analyzed by qPCR presence seven periodontal pathogens. Subjects monitored at baseline, 3, 6 12...

Abstract Aim The regulation of Wnt‐ β ‐catenin signalling, which is crucial for osteoblast differentiation and bone resorption, driven by critical inhibitors such as sclerostin ( SOST ) dickkopf‐related protein 1 DKK 1). As such, the aim this study was to evaluate involvement in human chronic periodontitis. Material Methods Gingival biopsies serum were sampled from systemically healthy non‐periodontitis n = 15) periodontitis subjects 15). mRNA levels SOST, DKK1 TNF‐ α periodontal tissues...

Abstract Aim To evaluate the clinical effects of different dosages metronidazole (MTZ) and durations MTZ + amoxicillin (AMX) in treatment generalized chronic periodontitis (GChP). Material Methods Subjects with severe GChP were randomly assigned to receive scaling root planing (SRP)‐only, or combined 250 400 mg AMX (500 mg) thrice a day (TID), for 7 14 days. monitored 1 year. Results One hundred nine subjects enrolled. At year, 61.9% 63.6% receiving days, respectively, reached endpoint (≤4...

We assessed the level of evidence for presence new periodontal pathogens by (i) comparing occurrence non-classical taxa between healthy vs. periodontitis patients (Association study); (ii) assessing modifications in prevalence and levels these species after treatments (Elimination study). In Association study, we compared 39 novel bacterial periodontally patients. Elimination analyzed samples from assigned to receive scaling root planing alone or with metronidazole+ amoxicillin TID/ 14 days....

A series of isolated studies has focused on the influence smoking bone around titanium implants. This study proposes to investigate impact two conditions, i.e., nicotine administration and cigarette smoke inhalation, healing implants.Forty-five Wistar rats were used. After anesthesia, tibiae surface was exposed a screw-shaped implant placed bilaterally. The animals randomly assigned one following groups: Group 1: control, n = 19; 2: intermittent 15; 3: subcutaneous (3 mg/kg) twice daily, 11....