Background and Objective: There is a bidirectional relationship between periodontal disease type‐2 diabetes mellitus (DM). Inflammatory mediators may negatively affect glycemic control, increased glucose levels resultant glycation end‐products alter the host response against bacterial infection. However, no agreement has been reached regarding effect of DM on subgingival microbiota. Therefore, purpose present study was to compare biodiversity in deep pockets subjects with chronic...

Background: Human postnatal stem cells have been identified in periodontal ligaments (PDLs). In this study, the vitro biologic properties of CD105 + enriched cell subsets from PDLs harvested deciduous (DePDL) and permanent (PePDL) teeth are comparatively assessed. Methods: PDL tissue was obtained 12 (six primary six permanent) which CD34 − CD45 were isolated by magnetic sorting. To identify quantitatively compare markers, DePDL PePDL assessed for CD166 surface antigen expression flow...

Background: The aim of this study was to evaluate the clinical and laboratory changes 3 months after full‐mouth scaling root planing in subjects with without diabetes mellitus. Methods: This performed using 10 type 2 mellitus who required insulin therapy (DM) healthy adult control (NDM) generalized chronic periodontal disease. Both groups were treated given oral hygiene instructions. Clinical parameters, including plaque index (PI), gingival (GI), probing depth (PD), recession (GR),...

Background: This study investigates the effect of photodynamic therapy (PDT) as monotherapy during supportive periodontal therapy. Methods: A split‐mouth, randomized controlled trial was conducted in patients with chronic periodontitis (N = 22) presenting at least three residual pockets (probing depth [PD] ≥5 mm bleeding on probing [BOP]). The selected sites randomly received following: 1) PDT; 2) photosensitizer (PS); or 3) scaling and root planing (SRP). At baseline 3 6 months, clinical,...

Objectives: To evaluate the effects of a 1% hyaluronic acid (HA) gel in combination with an absorbable collagen sponge (ACS) healing critical-size calvaria defects rats. Material and methods: Thirty-two adult Wistar rats were used. Two 5-mm-diameter created treatments randomly distributed as follows: (1) HA; (2) HA gel-soaked ACS; (3) control (blood clot); (4) ACS. The animals sacrificed 60 days post-surgery, when biopsies collected processed for histology histometric analysis. Bone fill was...

Background: The present study aims to compare the performance of minimally invasive non‐surgical and surgical approaches for therapy intrabony defects. Methods: Twenty‐nine patients who presented with defects were randomly assigned to: 1) a technique (MINST) group, or 2) (MIST) group. chair time each therapeutic procedure was calculated. probing depth (PD), position gingival margin (PGM) relative clinical attachment level (RCAL) evaluated at 3 6 months after treatments. patient perception...

To investigate the effect of photodynamic therapy (PDT) as adjunct to mechanical in furcations.A double-blind, parallel, randomized controlled clinical trial was conducted subjects presenting class II furcations. The were randomly allocated a test (PDT; n = 16) or control group (non-activated laser/only photosensitizer; 21). At baseline, 3 and 6 months, clinical, microbiological cytokine pattern evaluation performed. Clinical attachment level defined primary outcome variable.Clinical...

A series of isolated studies has focused on the influence smoking bone around titanium implants. This study proposes to investigate impact two conditions, i.e., nicotine administration and cigarette smoke inhalation, healing implants.Forty-five Wistar rats were used. After anesthesia, tibiae surface was exposed a screw-shaped implant placed bilaterally. The animals randomly assigned one following groups: Group 1: control, n = 19; 2: intermittent 15; 3: subcutaneous (3 mg/kg) twice daily, 11....

The purpose of this study was to evaluate the influence an estrogen-deficient state on bone around titanium implants placed in rats. Thirty female Wistar rats were divided into 2 groups: test (n = 15), ovariectomized (OVX); and control sham-operated Screw-type bilaterally 21 days after ovariectomy or sham surgery. After 60 days, animals killed undecalcified sections obtained. Blood samples collected obtain serum levels alkaline phosphatase at time killing. Bone-to-implant contact (BIC), area...

Abstract Aim: Evaluation of the treatment gingival recessions with coronally positioned flap or without acellular dermal matrix allograft (ADM) after a period 24 months. Methods: Thirteen patients bilateral were included. The defects randomly assigned to one treatments: plus ADM alone. clinical measurements taken before surgeries and 6, 12 Results: At baseline, mean values for recession height 3.46 3.58 mm treated graft, respectively ( p >0.05). No significant differences between groups...

The aim of this randomized clinical trial was to evaluate the treatment gingival recession associated with non-carious cervical lesions by a coronally advanced flap alone (CAF) or in combination resin-modified glass ionomer restoration (CAF+R).Nineteen subjects bilateral Miller Class I buccal recessions were selected. assigned randomly receive CAF CAF+R. Bleeding on probing (BOP), depth (PD), relative (RGR), attachment level (CAL), lesion height (CLH), and dentin sensitivity (DS) measured at...

The present study aimed to evaluate whether chronic stress (CS) affects ligature-induced periodontal disease and investigate the impact of CS on mRNA levels interleukin (IL)-1beta, -1 receptor antagonist, -6, -10, interferon-gamma (IFN-gamma), activator nuclear factor-kappa B ligand (RANKL), osteoprotegerin in gingival tissues rats.Sixty male Wistar rats were assigned randomly three groups: G1 (control; non-ligated sites), G2 (periodontal disease), G3 associated with restraint for 12...

The aim of the present study is to assess clinical, microbiologic, and immunologic benefits amoxicillin/metronidazole (AM) when performing full-mouth ultrasonic debridement (FMUD) in generalized aggressive periodontitis (GAgP) treatment.Twenty-four GAgP patients were divided into two groups: FMUD group (n = 12), which received plus placebo, FMUD+AM 375 mg amoxicillin 250 metronidazole for 7 days. following clinical outcomes tested: plaque bleeding on probing indices, pocket depth (PD),...

Background: Minimally invasive techniques have broadened the horizons of periodontal plastic surgery to improve treatment outcomes. Thus, purpose this clinical trial was compare root coverage, postoperative morbidity, and esthetic outcomes subepithelial connective tissue graft (SCTG) technique with or without use a surgical microscope in gingival recessions. Methods: In split‐mouth study, twenty‐four patients bilateral Miller's Class I II buccal recessions ≥2.0 mm canines premolars were...

Abstract Aim This study aimed to evaluate, histomorphometrically, the use of periodontal ligament cells ( PDL cells) in treatment class III furcation defects. Material and Methods were obtained from mandibular tooth extracted each dog (7), cultured vitro phenotypically characterized. Bilateral defects created at 3rd 4th premolars randomly assigned to: Control Group: coronally positioned flap, GTR , Sponge carrier + Cell . Results After 3 months healing, data analysis demonstrated that Group...

Abstract Background Gingival recession (GR) is frequently associated with non‐carious cervical lesion (NCCL) forming a combined defect (CD). The aim of this study was to evaluate new multidisciplinary protocol for CDs. Methods Forty patients presenting 40 Miller's Class I or II GR defects B+ tooth were randomly allocated one the following treatments: test group ( n = 20), partial restoration (PR) NCCL, in which apical border placed 1 mm beyond cement–enamel junction estimation, and...

Background: The aim of this study was to clinically evaluate the treatment Class I gingival recessions by coronally positioned flap with or without acellular dermal matrix allograft (ADM). Methods: Thirteen patients comparable bilateral Miller (≥3.0 mm) were selected. defects randomly assigned one treatments: and (ADM group) alone (CPF group). clinical parameters included: probing depth (PD), attachment level (CAL), recession height (RH), width (RW), keratinized tissue (HKT), thickness...

Background: The purpose of this randomized clinical trial was to compare the outcome gingival recession therapy using semilunar coronally positioned flap (SCPF) or subepithelial connective tissue graft (SCTG). Methods: Seventeen patients with bilateral Miller Class I buccal recessions (≤4 mm) in maxillary canines premolars were selected. randomly assigned receive either SCPF SCTG. Recession height (RH), width (RW), keratinized (WKT), thickness (TKT), probing depth (PD), and attachment level...

Background and Objective: This study evaluated the effect of smoking on gene expression interleukin‐1α, ‐1ra, ‐6, ‐8 ‐10, tumor necrosis factor‐α, matrix metalloproteinase (MMP)‐2 ‐8, receptor activator NF‐κB ligand (RANKL) osteoprotegerin, in sites with periodontitis. Material Methods: Gingival biopsies were divided into three groups: healthy group (periodontally subjects; n = 10); periodontitis [subjects severe chronic who never smoked (probing depth ≥ 7 mm) ( 25)]; (subjects diagnosed 1...