A5077139192- Advanced Drug Delivery Systems
- Lipid Membrane Structure and Behavior
- Advancements in Transdermal Drug Delivery
- Anesthesia and Pain Management
- Drug Solubulity and Delivery Systems
- Dental Anxiety and Anesthesia Techniques
- Surfactants and Colloidal Systems
- Nanoparticle-Based Drug Delivery
- Essential Oils and Antimicrobial Activity
- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Chromatography
- Pediatric Pain Management Techniques
- Anesthesia and Sedative Agents
- RNA Interference and Gene Delivery
- Erythrocyte Function and Pathophysiology
- Spectroscopy and Quantum Chemical Studies
- Spectroscopy and Chemometric Analyses
- Crystallography and molecular interactions
- Nanopore and Nanochannel Transport Studies
- Protein Interaction Studies and Fluorescence Analysis
- Crystallization and Solubility Studies
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- Extracellular vesicles in disease
- Dermatology and Skin Diseases
Universidade Estadual de Campinas (UNICAMP)
2016-2025
University of Copenhagen
2023-2025
Pontifícia Universidade Católica de Campinas
2021
Universidade Federal do ABC
2014-2017
Helmholtz-Zentrum Berlin für Materialien und Energie
2017
Universidade Federal do Rio de Janeiro
2012
Hospital de Clínicas da Unicamp
2005-2006
Universidade de São Paulo
1988-2002
Abstract Elucidation of the structural properties colloids is paramount for a successful formulation. However, intrinsic dynamism colloidal systems makes their characterization difficult task and, in particular, there lack physicochemical techniques that can be correlated to biological performance. Nanoparticle tracking analysis (NTA) allows measurements size distribution and nanoparticle concentration real time. Its over time also enables early detection physical instability not assessed by...
Bupivacaine (BVC; S75–R25, NovaBupi® is an amide-type local anesthetic. Sodium alginate a water-soluble linear polysaccharide. The present study reports the development of alginate/bis(2-ethylhexyl) sulfosuccinate (AOT) and alginate/chitosan nanoparticle formulations containing BVC (0.5%). amounts associated in alginate/AOT nanoparticles were 87 ± 1.5 76 0.9%, respectively. average diameters zeta potentials measured for 30 days, results demonstrated good stability these particles solution....
Objective: The aim of the present study was to encapsulate vancomycin in different liposomal formulations and compare vitro antimicrobial activity against Staphylococcus aureus biofilms. Methods: Large unilamellar vesicles conventional (LUV VAN), fusogenic (LUVfuso cationic (LUVcat VAN) liposomes encapsulating VAN were characterized terms size, polydispersity index, zeta potential, morphology, encapsulation efficiency (%EE) release kinetics. tested for their Minimum Inhibitory Concentration...
Abstract Inflammatory conditions of the temporomandibular joint (TMJ) and peripheral tissues affect many people around world are commonly treated with non-steroidal anti-inflammatory drugs (NSAIDs). However, in order to get desirable results, treatments NSAIDs may take weeks, causing undesirable side effects requiring repeated administration. In this sense, work describes development an optimized nanostructured lipid carrier (NLC) formulation for intra-articular administration naproxen...
Objective: To characterize liposomal-lidocaine formulations for topical use on oral mucosa and to compare their in vitro permeation vivo anesthetic efficacy with commercially available lidocaine formulations.Materials methods: Large unilamellar liposomes (400 nm) containing were prepared using phosphatidylcholine, cholesterol, α-tocoferol (4:3:0.07, w:w:w) characterized terms of membrane/water partition coefficient, encapsulation efficiency, size, polydispersity, zeta potential, release. In...
In this work, poloxamer (PL)-based binary hydrogels, composed of PL 407 and 188, were studied with regard to the physicochemical aspects sol-gel transition pharmaceutical formulation issues such as dissolution-release profiles. particular, we evaluated cytotoxicity, genotoxicity, in vivo pharmacological performance 407-PL 188 hydrogels containing tramadol (TR) analyze its potential treatment acute pain. Drug-micelle interaction studies showed formation systems drug partitioning into...
This study reports the development of nanostructured hydrogels for sustained release eutectic mixture lidocaine and prilocaine (both at 2.5%) intraoral topical use. The local anesthetics, free or encapsulated in poly(ε-caprolactone) nanocapsules, were incorporated into CARBOPOL hydrogel. nanoparticle suspensions characterized vitro terms particle size, polydispersity, surface charge, using dynamic light scattering measurements. concentrations determined by tracking analysis. Evaluation was...
The use of biomaterials composed organic pristine components has been successfully described in several purposes, such as tissue engineering and drug delivery. Drug delivery systems (DDS) have shown advantages over traditional therapy, greater therapeutic efficacy, prolonged profile, reduced toxicity, evidenced by vitro vivo studies well clinical trials. Despite that, there is no perfect carrier, issues undesirable viscosity physicochemical stability or inability to efficiently encapsulate...