A5051212177- Venomous Animal Envenomation and Studies
- Healthcare and Venom Research
- Neurobiology and Insect Physiology Research
- Antifungal resistance and susceptibility
- Antimicrobial Peptides and Activities
- Lipid Membrane Structure and Behavior
- Biochemical and Structural Characterization
- Ion channel regulation and function
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cholinesterase and Neurodegenerative Diseases
- Muscle metabolism and nutrition
- Cardiovascular Health and Disease Prevention
- Hormonal and reproductive studies
- Blood Coagulation and Thrombosis Mechanisms
- Insect and Pesticide Research
- Advanced Drug Delivery Systems
- Heart Rate Variability and Autonomic Control
- Organoselenium and organotellurium chemistry
- Cardiovascular and exercise physiology
- Exercise and Physiological Responses
- Nitric Oxide and Endothelin Effects
- Fungal Infections and Studies
- Mitochondrial Function and Pathology
- Respiratory and Cough-Related Research
- Medical and Biological Ozone Research
Universidade Federal do ABC
2016-2025
Methodist University of Piracicaba
2000-2022
Universidade Federal do Ceará
2011-2021
Universidade de São Paulo
2015
Universidade Federal de Pernambuco
2011
Universidade Nove de Julho
2008-2010
Instituto Butantan
2003-2008
University of Amsterdam
1992
Functional characterization of peptide fraction (PF) from snake venom has provided novel opportunities to investigate possible neuroprotective compounds relevant pharmaceuticals. This study was performed the PF-mediated neuroprotection obtained Naja mandalayensis venom, a member Elapidae family, using two neuronal cell lines: undifferentiated PC12 and differentiated mHippoE-18, in response H2O2-induced oxidative stress. Cells were pretreated for 4 h with PF (10, 1, 0.01, 0.001 μg mL⁻1),...
Background: The bioactive peptides derived from snake venoms of the Viperidae family species have been promising as therapeutic candidates for neuroprotection due to their ability prevent neuronal cell loss, injury, and death. Therefore, this study aimed evaluate cytoprotective effects a synthetic proline-rich oligopeptide 7a (PRO-7a; <EDGPIPP) Bothrops jararaca snake, on oxidative stress-induced toxicity in PC12 cells astrocyte-like C6 cells. Methods: Both were pre-treated four hours with...
Abstract The bradykinin‐potentiating peptides from Bothrops jararaca venom are the most potent natural inhibitors of angiotensin‐converting enzyme. biochemical and biological features these were crucial to demonstrate pivotal role enzyme in blood pressure regulation. In present study, seven identified within C‐type natriuretic peptide precursor cloned snake brain. deduced B. brain strong vitro (nanomolar range), also potentiate bradykinin effects ex vivo experiments. Two novel peptides, one...
Functional characterization of peptide fraction (PF) from snake venom has provided novel opportunities to investigate possible neuroprotective compounds relevant pharmaceuticals. This study was performed the PF-mediated neuroprotection obtained Naja mandalayensis venom, a member Elapidae family, using two neuronal cell lines, undifferentiated PC12 and differentiated mHippoE-18, in response H2O2-induced oxidative stress. Cells were pre-treated for 4 h with PF (10, 1, 0.01, 0.001 μg mL-1),...
Snake venoms are rich sources of bioactive peptides with therapeutic potential, particularly against neurodegenerative diseases linked to oxidative stress. While the peptide fraction (&lt; 10 kDa) from Bothrops jararaca venom has shown in vitro neuroprotection, analogous fractions related species remain unexplored vivo. This study comparatively evaluated neuroprotective effects two (pf) Daboia siamensis (pf-Ds) and B. (pf-Bj) H₂O₂-induced stress using (PC12 cells) vivo (zebrafish, Danio...
Introduction. The proline-rich decapeptide 10c (Bj-PRO-10c; ENWPHPQIPP) from the Bothrops jararaca snake modulates argininosuccinate synthetase (AsS) activity to stimulate L-arginine metabolite production and neuroprotection in SH-SY5Y cell line. relationships between structure, interactions with AsS, are little known. We evaluated neuroprotective effects of Bj-PRO-10c three other PROs (Bn-PRO-10a, <ENWPRPKIPP; Bn-PRO-10a-MK, <ENWPRPKIPPMK; and, Bn-PRO-10c, <ENWPRPKVPP) identified...
Introduction: Snake venoms are rich sources of bioactive peptides with therapeutic potential, particularly against neurodegenerative diseases linked to oxidative stress. While the peptide fraction (<10 kDa) from Bothrops jararaca venom has shown in vitro neuroprotection, analogous fractions related species remain unexplored vivo. Methods: This study comparatively evaluated neuroprotective effects two (pf) Daboia siamensis (pf-Ds) and B. (pf-Bj) H2O2-induced stress using (PC12 cells) vivo...
The functionality of the disintegrin‐like/cysteine‐rich domains snake venom metalloproteinases (SVMPs) has been shown to reside in cysteine‐rich region, which can interact with VWA‐containing proteins. Recently, hyper‐variable region (HVR) domain was suggested constitute a potential protein–protein adhesive interface. Here we show that recombinant proteins HF3, hemorrhagic P‐III SVMP, containing (disintegrin‐like/cysteine‐rich and proteins) but not disintegrin‐like protein were able...
Bradykinin-potentiating peptides (BPPs – 5a, 7a, 9a, 10c, 11e, and 12b) of Bothrops jararaca (Bj) were described as argininosuccinate synthase (AsS) activators, improving l-arginine availability. Agmatine polyamines, which are metabolism products, have neuroprotective properties. Here, we investigated the effects low molecular mass fraction from Bj venom (LMMF) two synthetic BPPs (BPP-10c, <ENWPHPQIPP; BPP-12b, <EWGRPPGPPIPP) in SH-SY5Y cell line against H2O2-induced oxidative stress. The...
Clinical and experimental studies have demonstrated some negative effect of hypertension on bone mineral density. The aim this study was to evaluate healing trabecular area (TBA) in spontaneously hypertensive rats (SHR), a well-established model essential hypertension, when compared normotensive (NTR). A critical-size defect surgically created the right tibia SHR (n = 12) (NTR; n 12), while contralateral left intact. Eight days later, animals were sacrificed specimens processed order obtain...
Chitosan-tripolyphosphate (CS-TPP) nanoparticles containing naproxen (NPX) were dispersed in poloxamer (PL) as unique (PL407) or binary (PL407-PL403) systems. Nanoparticles presented diameter of ∼250 nm and zeta potential ∼35 mV with drug loading encapsulation efficiency 98.4 ± 0.3% 36.9 0.12%, respectively. NPX-CS-TPP shifted the sol-gel transition micellization temperatures. PL407-PL403 systems G′ > G″ compared to PL407. SAXS patterns revealed transitions from lamellar hexagonal phase...