A5068903875- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- Diet and metabolism studies
- Amino Acid Enzymes and Metabolism
- Neuroscience and Neuropharmacology Research
- Metabolomics and Mass Spectrometry Studies
- Muscle metabolism and nutrition
- Alcoholism and Thiamine Deficiency
- Adipose Tissue and Metabolism
- Folate and B Vitamins Research
- Biochemical effects in animals
- Vitamin K Research Studies
- Peroxisome Proliferator-Activated Receptors
- Biochemical Acid Research Studies
- Melanoma and MAPK Pathways
- Coenzyme Q10 studies and effects
- Fatty Acid Research and Health
- Clinical Nutrition and Gastroenterology
- Antioxidant Activity and Oxidative Stress
- Vitamin C and Antioxidants Research
- Sulfur Compounds in Biology
- Tryptophan and brain disorders
- RNA regulation and disease
- Palliative and Oncologic Care
- Calpain Protease Function and Regulation
Universidade Federal do ABC
2016-2025
Universidade do Vale do Rio dos Sinos
2025
Hospital Braga
2024
Radiology Associates of Albuquerque
2018
Universidade Federal do Rio Grande do Sul
2006-2016
Hospital de Clínicas de Porto Alegre
2013
Universidade Federal do Rio Grande
2011
Universidade Federal de Ciências da Saúde de Porto Alegre
2003-2009
Instituto de Saúde
2007
Universidade Luterana do Brasil
2003
Vemurafenib is a BRAF (rapidly accelerated fibrosarcoma B-type)-targeted therapy used to treat patients with advanced, unresectable melanoma. It inhibits the MAPK (mitogen-activated protein kinase)/ERK (extracellular signal-regulated kinase) pathway and tumor proliferation in BRAFV600E-mutated melanoma cells. Resistance vemurafenib has been reported due secondary NRAS (neuroblastoma RAS viral oncogene homolog) mutations, which lead paradoxical activation proliferation. However, impact of...
Abstract In the present study we investigated effect of intrastriatal administration 150 nmol quinolinic acid to young rats on critical enzyme activities energy production and transfer, as well 14 CO 2 from [1– C]acetate at distinct periods after injection. We observed that injection significantly inhibited complexes II (50%), III (46%) II–III (35%), creatine kinase (27%), but not I IV citrate synthase in striatum prepared 12 h treatment. contrast, no alterations these were 3 or 6...
Melanoma is a malignant proliferative disease originated in melanocytes, characterized by high metastatic activity and the activation of oncogenes, such as B-RAF (40–60% cases). Recent studies have shown that vemurafenib (a MAPK inhibitor) promoted disturbance mitochondrial bioenergetics, although underlying mechanisms are not fully comprehended. Here we showed inhibition B-RAFV600E-mutated human melanoma culminated DRP1 phosphorylation, associated to large network remodeling hyperfused...
Cardiorenal syndrome (CRS) is a pathological link between the kidneys and heart, in which an insult kidney or heart leads other organ to incur damage. CRS classified into five subtypes, type 3 (CRS3) characterized by acute injury as precursor subsequent cardiovascular changes. Mitochondrial dysfunction oxidative nitrosative stress have been reported pathophysiology of CRS3. It known that vitamin C, antioxidant, has proven protective capacity for cardiac, renal, vascular endothelial tissues....
Glutaric acidemia type I (GA-I) is an inherited neurometabolic childhood disorder caused by defective activity of glutaryl CoA dehydrogenase (GCDH) which disturb lysine (Lys) and tryptophan catabolism leading to neurotoxic accumulation glutaric acid (GA) related metabolites. However, it remains unknown whether GA toxicity due direct effects on vulnerable neurons or mediated GA-intoxicated astrocytes that fail support neuron function survival. As damaged can also contribute sustain high...
Bradykinin-potentiating peptides (BPPs – 5a, 7a, 9a, 10c, 11e, and 12b) of Bothrops jararaca (Bj) were described as argininosuccinate synthase (AsS) activators, improving l-arginine availability. Agmatine polyamines, which are metabolism products, have neuroprotective properties. Here, we investigated the effects low molecular mass fraction from Bj venom (LMMF) two synthetic BPPs (BPP-10c, <ENWPHPQIPP; BPP-12b, <EWGRPPGPPIPP) in SH-SY5Y cell line against H2O2-induced oxidative stress. The...
Abstract 3‐Methylglutaconic aciduria (MGTA) comprehends a group of disorders biochemically characterized by accumulation 3‐methylglutaric acid (MGA), 3‐methylglutaconic (MGT) and occasionally 3‐hydroxyisovaleric (OHIVA). Although neurological symptoms are common in the affected individuals, mechanisms brain damage poorly known. In present study we investigated vitro effect MGA, MGT OHIVA, at concentrations ranging from 0.1 to 5.0 mM, on bioenergetics oxidative stress synaptosomal...
3-Hydroxy-3-methylglutaryl-coenzyme A lyase (HL) deficiency is characterized by tissue accumulation of 3-hydroxy-3-methylglutaric (HMG), and 3-methylglutaric (MGA) acids. Affected patients present cardiomyopathy, whose pathomechanisms are not yet established. We investigated the effects HMG MGA on energy redox homeostasis in rat heart using vivo vitro models. In experiments showed that intraperitoneal administration decreased activities respiratory chain complex II creatine kinase (CK),...
Abstract l ‐2‐Hydroxyglutaric acid (LGA) is the biochemical hallmark of patients affected by neurometabolic disorder known as ‐2‐hydroxyglutaric aciduria (LHGA). Although this predominantly characterized severe neurological findings and pronounced cerebellum atrophy, neurotoxic mechanisms brain injury are virtually unknown. In present study, we investigated effect LGA, at 0.25–5 mM concentrations, on total creatine kinase (tCK) activity from cerebellum, cerebral cortex, cardiac muscle...