A5054163001- Venomous Animal Envenomation and Studies
- Marine Invertebrate Physiology and Ecology
- Erythrocyte Function and Pathophysiology
- Zebrafish Biomedical Research Applications
- Asthma and respiratory diseases
- Immune Response and Inflammation
- Aquaculture disease management and microbiota
- Invertebrate Immune Response Mechanisms
- Antimicrobial Peptides and Activities
- Vibrio bacteria research studies
- Ion channel regulation and function
- MicroRNA in disease regulation
- T-cell and B-cell Immunology
- Healthcare and Venom Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Pediatric health and respiratory diseases
- Cell Adhesion Molecules Research
- interferon and immune responses
- Reproductive System and Pregnancy
- Inflammasome and immune disorders
- Pesticide Exposure and Toxicity
- Mast cells and histamine
- IL-33, ST2, and ILC Pathways
- Fish Biology and Ecology Studies
- Retinal Development and Disorders
Universidade Federal do Ceará
2025
Instituto Butantan
2015-2025
Fundação de Amparo à Pesquisa do Estado de São Paulo
2013-2024
Universidade do Porto
2022-2024
Instituto Nacional de Investigação Agrária e Veterinária
2023
Centro Hospitalar Tondela-Viseu
2022
Universidade de Cuiabá
2021
John Wiley & Sons (United States)
2019
Ecological Society of America
2019
IFC Research (United Kingdom)
2019
Acute-phase protein (APPs) serum levels have been studied in many human diseases, and their components contribute to host defense during the evolution of infectious diseases by acting as part innate immune system. Based on importance establishing new experimental models, present investigation evaluated modulation APPs following inflammatory stimulus inoculation Aeromonas hydrophila tilapias. Fish were sampled 6 24 hours post-infection. Tilapias presented increase positive such ceruloplasmin,...
Lectins are glycan-binding receptors that recognize glycan epitopes on foreign pathogens and in the host systems. They can be involved functions include innate immunity, development, immune regulation homeostasis. Several lectins have been purified characterized from fish species. In this work, using cation-exchange chromatography, a galactose-specific lectin belonging to family of C-type was isolated venom Brazilian venomous Thalassophryne nattereri. Nattectin is basic, non-glycosilated, 15...
Summary Background The increase of atopic disorders in developed countries has been associated with the decline infectious diseases, including helminthic infections. We have already demonstrated that adult worm extracts from Ascaris suum (ASC) suppress IgE antibody production against unrelated antigens. Objective Here we investigated influence ASC on development pulmonary eosinophilic inflammation a murine model asthma. Methods Heat‐coagulated egg white alone (EWI) or mixed (EWI + ASC) was...
Recently our group described that Nattectin, a C-type lectin of the venom Thalassophryne nattereri shows potent pro-inflammatory capacity. Here, we demonstrated Nattectin is able to induce M1 macrophage marker iNOS, and up-regulate expression MHC class II, CD80, CD86 CD40 molecules. The increase in II CD49a integrin with MMP-9 production endocytic capacity depend on function Nattectin. Moreover, polarization peritoneal bone marrow-derived macrophages induced by profile dependent Th1...
Stingrays from the Potamotrygon cf. henlei species are widely distributed in high numbers throughout rivers of central-west Brazil, being source numerous envenomations occurring dry season, posing a serious public health problem even if not properly reported. The accidents usually involve fishermen and bathers, to date there is no effective treatment for injured. Considering these facts limitations studies aiming at understanding effects induced by P. envenoming, this study aimed describe...
Cathorops spixii is the most common venomous fish on Brazilian coast. Apart from involvement with defense against pathogens, possible contribution of skin mucus components to development injuries caused by species has not been investigated. Thus, present study was conducted gain a better understanding peptide and protein sting venom catfish C. spixii. Our results show that have distinct constituents distinguished them like structural proteins, chaperones, ion transport, carbohydrate...
Background The caterpillar of Premolis semirufa , known as Pararama, is found in the Brazilian Amazon, primarily on rubber trees genus Hevea . Pararamosis an inflammatory disease resulting from accidental contact with caterpillar’s bristles, leading to acute and chronic symptoms. Chronic exposure can cause significant osteoarticular deformities, similar those seen osteoarthritis rheumatoid arthritis, due cartilage degradation synovial inflammation. Currently, there are no specific treatments...
Abstract Background: Brazilian waters are home to various venomous fish species, each with its unique venom composition. Although common, envenomation cases largely underreported, leading a lack of public health policies for prevention and treatment. Some the most clinically relevant in Brazil include stingray Potamotrygon orbignyi, toadfish Thalassophryne nattereri, scorpionfish Scorpaena plumieri, catfish Pseudoplatystoma fasciatum Cathorops spixii. Methods: We comprehensively searched...
HF3 and bothropasin are P-III hemorrhagic snake venom metalloproteinases (SVMPs) of Bothrops jararaca. The DC protein is composed the disintegrin-like/cysteine-rich domains derived from autolysis SVMPs. Here we describe simplified procedures for isolation HF3, bothropasin, protein, BJ-PI, a novel P-I SVMP. isolated proteins were identified by mass spectrometry. BJ-PI potent caseinolytic enzyme devoid activity. show distinct fibrinogenolytic activities.
Considerable efforts are currently focused on the biology of DC in view their possible clinical use as adjuvant for generation antigen-specific immunity and lifelong immunologic memory or treatment tumors. We assessed role Nattectin a C-type lectin identified Thalassophryne nattereri fish venom maturation. induced significant neutrophilic recruitment into peritoneal cavity mice, followed by macrophages, with lipidic mediators IL-12 p70 synthesis. Macrophages derived from 7 day-Nattectin mice...