A5051392526- Veterinary Oncology Research
- Infectious Diseases and Mycology
- Antimicrobial Resistance in Staphylococcus
- Breast Lesions and Carcinomas
- Bacterial Identification and Susceptibility Testing
- Microbial infections and disease research
- Health, Nursing, Elderly Care
- Virus-based gene therapy research
- Cancer Cells and Metastasis
- Women's cancer prevention and management
- Metastasis and carcinoma case studies
- Genomics and Chromatin Dynamics
- Cancer and Skin Lesions
- T-cell and B-cell Immunology
- Tailings Management and Properties
- Cancer Mechanisms and Therapy
- Hydropower, Displacement, Environmental Impact
- Infections and bacterial resistance
- Cytomegalovirus and herpesvirus research
- Stress and Burnout Research
- Infectious Disease Case Reports and Treatments
- Healthcare during COVID-19 Pandemic
- Science and Education Research
- Fibroblast Growth Factor Research
- Central Venous Catheters and Hemodialysis
Oxford University Hospitals NHS Trust
2024
University of Lisbon
2013-2022
Universidade Federal do Rio de Janeiro
2000-2022
Escola Superior de Saúde Egas Moniz
2022
Hospital Pedro Hispano
2016-2022
Centre for Research in Anthropology
2022
Universidade Lusófona
2018-2020
Microbiology Society
2004
Hospital de Santo António
2004
Universidade Federal do Piauí
2001
Molecular classification of feline mammary carcinomas (FMC) from which specific behavioral patterns may be estimated has potential applications in veterinary clinical practice and comparative oncology. In this perspective, the main goal study was to characterize both pathological features different molecular phenotypes found a population FMC (n = 102), using broadly accepted IHC-based established by St. Gallen International Expert Consensus panel. The luminal B/HER2-negative subtype most...
Considering that scarce data are available on disease progression of feline mammary carcinoma (FMC), this study aimed to analyze the clinical, pathological, and immunophenotypic features collected from 61 queens with FMC compare concordance ratios expression levels five molecular markers (ER, PR, fHER2, CK5/6, Ki-67) between primary tumors (PT) metastatic lesions. The results showed cats luminal A carcinomas (MC) had higher overall survival (924.6 days, p = 0.001) longer disease-free period...
HER2 is overexpressed in about 30% of feline mammary carcinomas (FMC) and 15-30% breast cancers. Women with HER2-positive tumors are associated shorter survival. This study aimed to optimize the detection quantification serum (sHER2) cats evaluate its potential diagnosing (MC) overexpressing HER2. A prospective was conducted 60 queens showing MC 20 healthy animals. Pre-operative samples were collected for sHER2 using two immunoassays: ELISA Dot blot assay. levels compared tissue status...
Cytotoxic T lymphocyte associated antigen 4 (CTLA-4) serves an important role in breast cancer progression, which has led to the development of novel immunotherapies aimed at blocking tumor immune evasion. Although feline mammary carcinoma is increasingly recognized as a valuable model, no studies on CTLA-4 function had been conducted this species. The serum CTLA-4, TNF-α and IL-6 levels 57 female cats with were determined by ELISA, immunohistochemistry was performed evaluate FoxP3...
As abordagens interdisciplinares têm um impacto significativo no manejo de Doenças Crônicas Não Transmissíveis (DCNT), promovendo cuidado holístico que considera não apenas os sintomas físicos, mas também aspectos emocionais, sociais e comportamentais do paciente. Este estudo tem como objetivo identificar a importância da abordagem interdisciplinar ao paciente com doenças crônicas. Foi realizada uma pesquisa revisão integrativa literatura nas bases dados PubMed Scielo, abrangendo artigos...
Este estudo teve como objetivo analisar os fatores associados ao Burnout em profissionais de saúde e identificar intervenções possíveis para mitigar seus impactos. A pesquisa foi realizada por meio uma revisão literatura nas bases SciELO LILACS, contemplando publicações dos últimos cinco anos (2019-2024). Utilizaram-se descritores "Burnout", "profissionais saúde" "intervenções", resultando 72 artigos, quais 10 atenderam aos critérios inclusão. Os consideraram estudos português, disponíveis...
Abstract Human epidermal growth factor receptor (HER2) is a tumor biomarker that when overexpressed and/or amplified associated with poor prognosis for women breast cancer. This specific subtype eligible immunotherapy increases survival period. However, in feline oncology, only few studies have been performed on molecular characterization of ( f HER2) mammary carcinoma (FMC), and the available data are inconsistent. In this study, HER2 protein levels gene status FMC were evaluated by...
Ki-67 is a nuclear protein and proliferation marker frequently used in establishing the prognosis for breast cancer patients. To investigate prognostic value of index female cats with mammary carcinoma, prospective study was conducted 96 animals. The primary tumors ( n = 96) initially determined, whenever possible, regional lymph node metastasis 38) distant 16) also estimated. optimal cutoff determined by univariate multivariate analysis. indices ≥14% were detected 72.9% (70 tumors. Tumors...
In humans, the ERBB2 gene amplification and overexpression are biomarkers for invasive breast cancer a therapeutic target.Also, TOP2α aberrations predict response to anthracycline-based adjuvant chemotherapy.Although feline mammary tumors (FMTs) good models in comparative oncology, scarce data is available regarding status.In this study, first time, DNA status RNA levels of intracellular (ICD) extracellular (ECD) coding regions were compared with expression profile, samples FMTs disease-free...
The extensive geographic spread of MRSA isolates belonging to the Brazilian epidemic clone (BEC) limited value pulsed-field gel electrophoresis (PFGE) in epidemiological studies outbreaks caused by these strains. Thus, discriminatory power eight different molecular methods was evaluated an attempt establish a methodology for genotyping BEC involved intra-hospital outbreaks. from five hospitals Teresina City, Piaui State were genotyped conventional or PFGE Cla I- Sma I-digested genomic DNA...
The feline mammary carcinoma (FMC) is the third most common tumor in cat, sharing many clinicopathological features with human breast cancer and thus, considered a suitable model for comparative oncology. Due to its poor prognosis, further studies are required improve diagnostic accuracy treatment of cats spontaneous carcinoma. Recently, it was reported that overexpression stromal cell-derived factor-1 (SDF-1) has great value diagnosis, suggesting tools therapies targeting SDF-1 ligand can...
Four cases of tumors in which cell internalization was frequently visualized are reported: one feline mammary carcinoma, cutaneous squamous canine pulmonary carcinoma and pleural mesothelioma. Cell observed by cytology two these (the tumour the effusion mesothelioma) histopathology all but Immunohistochemical staining for pancytokeratin positive both internalized host cells, while E-cadherin expression absent, although cells occasionally stained positive. This cell-to-cell interaction seems...
Works on cancer-related genes expression using feline mammary carcinomas (FMCs) are scarce but crucial, not only to validate these tumours as models for human breast cancer studies also improve small animal practice. Here, the of TP53, CCND1, FUS, YBX1, PTBP1, c-MYC and PKM2 was evaluated by real-time RT-qPCR, in a population FMCs clinically characterized compared with disease-free tissue same individual. In most analysed, RNA quantification revealed normal levels c-MYC, YBX1 overexpression...
Adoptive transfer of autologous regulatory T cells (Tregs) is a promising therapeutic strategy aimed at enabling immunosuppression minimization following kidney transplantation. In our phase 1 clinical trial Treg therapy in living donor renal transplantation, the ONE Study (ClinicalTrials.gov: NCT02129881), we observed focal lymphocytic infiltrates protocol transplant biopsies that are not regularly seen patients receiving standard immunosuppression.
Satellite noncoding RNAs (ncRNAs) are a new frontier of cancer biology research and biomarkers. While the knowledge on ncRNAs in human cancers is still limited, studies other species can be informative to guide future translational development for molecular targets diagnostics. In this context, FA-SAT major satellite DNA cat genome, which also present humans, being transcribed both species. study, we report insights (DNA RNA) profile feline mammary tumors, using disease-free tissues from...
The identification of genome-wide expression profiles that discriminate different molecular subtypes diseases became a recent field research, with visible impact in cancer research. In breast cancer, immunophenotyping the tumor is critical to support therapeutic decisions. Over last years, some studies revealed high percentage F eline M ammary T umours (FMTs) display f HER2 overexpression followed by very short survival period, like woman HER2-positive cancer. Usually, FMTs are malignant and...
Pandoraea species are a newly described genus of multidrug-resistant, non-fermentative Gram-negative bacilli, mainly isolated from sputum samples cystic fibrosis patients. In immunocompromised patients or with high antibiotic selective pressure, these pathogens generally opportunistic and invasive. Although spp. rare, the true incidence infections may be underestimated due to difficulties in microbial identification by phenotypic methods. We present case 51-year-old woman, new-onset fever...
This study investigated how environmental education has been implemented in public schools and the main challenges faced this process. The overall objective was to analyze practices schools, identifying obstacles opportunities. methodology adopted bibliographic, based on analysis of books, articles dissertations subject. results revealed that, although is recognized as important, its implementation faces difficulties such lack infrastructure, specific training for teachers difficulty...