A5048569165- Veterinary Oncology Research
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- melanin and skin pigmentation
- Regulation of Appetite and Obesity
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer survivorship and care
- Viral gastroenteritis research and epidemiology
- Infectious Diseases and Mycology
- T-cell and Retrovirus Studies
- T-cell and B-cell Immunology
- Virus-based gene therapy research
- Viral Infections and Immunology Research
University of Lisbon
2020-2023
Centre for Research in Anthropology
2021-2023
Département Santé Animale
2021
Tumor microenvironment has gained great relevance due to its ability regulate distinct checkpoints mediators, orchestrating tumor progression. Serum programmed cell death protein-1 (PD-1) and ligand-1 (PD-L1) levels were compared with healthy controls serum cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) necrosis factor-alpha (TNF-α) in order understand the role of PD-1/PD-L1 axis cats mammary carcinoma. PD-1 PD-L1 expression was evaluated tumor-infiltrating lymphocytes (TILs) cancer...
Cytotoxic T lymphocyte associated antigen 4 (CTLA-4) serves an important role in breast cancer progression, which has led to the development of novel immunotherapies aimed at blocking tumor immune evasion. Although feline mammary carcinoma is increasingly recognized as a valuable model, no studies on CTLA-4 function had been conducted this species. The serum CTLA-4, TNF-α and IL-6 levels 57 female cats with were determined by ELISA, immunohistochemistry was performed evaluate FoxP3...
Abstract Tumor microenvironment has gained great relevance due to its ability regulate distinct checkpoints mediators, orchestrating tumor progression. In order understand the role of PD- 1/PD-L1 axis in cats with mammary carcinoma, serum PD-1 and PD-L1 levels were compared healthy controls CTLA-4 TNF- α levels. expression was evaluated TILs cancer cells, as presence somatic mutations. Results showed that significantly higher HER2-positive (p=0.017; p=0.032) triple negative (TN) normal-like...
Obesity is an established risk factor for breast cancer in post-menopausal women, being associated with elevated serum levels of leptin. Although overweight a common condition cat, the role leptin and its receptor feline mammary carcinoma remains unsettled. In this study, (ObR) were investigated 58 cats compared those healthy animals, as expression ObR tumor tissues. The results showed that Free Leptin Index significantly decreased ( p = 0.0006), particularly luminal B HER2-positive tumors,...
African Swine Fever (ASF) is a highly contagious disease caused by double-stranded DNA virus (ASFV). Despite significant advances made over the last decade, issues such as residual virulence and absence of differentiating infected from vaccinated animals (DIVA) capacity remain an obstacle in development live attenuated vaccines (LAVs) against ASFV. It is, therefore, necessary to identify novel strategies improve vaccine safety, rational mutagenesis associated genes generation DIVA markers....
Abstract Obesity is a risk factor for human breast cancer, being associated with increased serum levels of leptin. In cat, although obesity common nutritional disorder, the role leptin and its receptor in mammary carcinoma unknown. this study, (ObR) were evaluated 58 cats compared healthy controls by ELISA, as tumour expression immunohistochemistry. Results showed that free index decreased (p=0.0006), particularly those luminal B HER2-positive disease significantly lower (p<0.0001...