A5014230085- Oral microbiology and periodontitis research
- Immune Response and Inflammation
- Oral Health Pathology and Treatment
- Streptococcal Infections and Treatments
- Inflammatory mediators and NSAID effects
- Fatty Acid Research and Health
- Dental Implant Techniques and Outcomes
- Periodontal Regeneration and Treatments
- Dental Health and Care Utilization
- Salivary Gland Disorders and Functions
- HIV/AIDS oral health manifestations
- S100 Proteins and Annexins
- Oral and gingival health research
- Dental Radiography and Imaging
- Endodontics and Root Canal Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Bone Metabolism and Diseases
- Advanced Glycation End Products research
- Bone Tissue Engineering Materials
- Antimicrobial Peptides and Activities
- Cell Adhesion Molecules Research
- Bone health and treatments
- Immune cells in cancer
- NF-κB Signaling Pathways
- Bone and Dental Protein Studies
Harvard University
2015-2025
Boston University
2007-2024
Forsyth Technical Community College
2024
Novant Health Forsyth Medical Center
2017-2023
University at Buffalo, State University of New York
1979-2023
University of Connecticut
2023
University of Michigan
2023
University of Maryland, College Park
2023
Hadassah
2018-2021
Beirut Arab University
2015
Dendritic cells (DCs) are pivotal in determining the class of an adaptive immune response. However, molecular mechanisms within DCs that determine this decision-making process unknown. Here, we demonstrate distinct Toll-like receptor (TLR) ligands instruct human to induce Th cell responses by differentially modulating mitogen-activated protein kinase signaling. Thus, Escherichia coli LPS and flagellin, which trigger TLR4 TLR5, respectively, stimulate Th1 via IL-12p70 production, depends on...
Longitudinal data were collected over a period of at least 18 months and up to 3 years on 41 adult periodontitis patients (AAP Type III IV). Ramfjord attachment level measurements sampling crevicular fluid (CF) each tooth repeated every months. A mean full mouth CF prostaglandin E 2 (MCF‐PGE) value was determined for patient visit. The three‐month monitoring continued until single site demonstrated statistically clinically significant loss (ALOSS) episode. Results indicated that in ALOSS the...
Abstract The adaptive immune system has evolved distinct responses against different pathogens, but the mechanism(s) by which a particular response is initiated poorly understood. In this study, we investigated type of Ag-specific CD4+ Th and CD8+ T cell elicited in vivo, to soluble OVA, coinjected with LPS from two pathogens. We used Escherichia coli LPS, signals through Toll-like receptor 4 (TLR4) oral pathogen Porphyromonas gingivalis, does not appear require TLR4 for signaling....
Abstract The adaptive immune system can generate distinct classes of responses, but the mechanisms that determine this are poorly understood. In study, we demonstrate different Toll-like receptor (TLR) ligands induce dendritic cell (DC) activation and responses in vivo. Thus, Escherichia coli LPS (TLR-4 stimulus), activates DCs to produce abundant IL-12(p70), little IL-10, stimulates Th1 Tc1 responses. contrast, Pam-3-cys (TLR-2 stimulus) elicits less favors Th2 T cytotoxic 2 (Tc2) These...
Abstract Resolvin E1 (RvE1) is a potent proresolving mediator of inflammation derived from omega-3 eicosapentaenoic acid that acts locally to stop leukocyte recruitment and promote resolution. RvE1 displays counter-regulatory tissue-protective actions in vitro vivo. Periodontal disease local inflammatory initiated by bacteria characterized neutrophil-mediated tissue injury followed development chronic immune lesion. In this study, we report the treatment established periodontitis using as...
Periodontitis is a well-appreciated example of leukocyte-mediated bone loss and inflammation that has pathogenic features similar to those observed in other inflammatory diseases such as arthritis. Resolvins are new family bioactive products omega-3 fatty acid transformation circuits initiated by aspirin treatment counter proinflammatory signals. Because it now increasingly apparent local plays critical role many diseases, including cardiovascular disease, atherosclerosis, asthma,...
Polymorphonuclear leukocyte (PMNL) chemotaxis studies of 32 patients with localized juvenile periodontitis (periodontosis or LJP), 10 adult a history LJP (post-LJP), 8 generalized (GJP), and 23 adults moderate to severe were performed: (i) determine the prevalence PMNL defect in large group patients; (ii) study other forms periodontal disease; (iii) if seen is cell-associated mediated by humoral factors. The effect treatment on was studied nine patients. chemotactic response measured Boyden...
This Editors' Consensus is supported by an educational grant from Colgate-Palmolive, Inc., New York, and based on a meeting of the authors held in Boston, Massachusetts, January 9, 2009.Dr. Friedewald has received honoraria for speaking Novartis, East Hanover, Jersey. Dr. Kornman full-time employee shareholder Interleukin Genetics, Waltham, which owns patents genetic biomarkers chronic inflammatory diseases. Genco consultant to Merck, Whitehouse Station, Ridker research support AstraZeneca,...
Objective— Epidemiological and recent clinical studies implicate periodontitis as an independent risk factor for cardiovascular disease. Previously, we demonstrated that rabbits with experimental cholesterol diet exhibit more aortic plaque compared alone. We also showed a proresolution mediator, Resolvin E1 (RvE1), reverses the periodontitis. Here, determined whether oral/topical application of RvE1 attenuates atherosclerosis induced by both periodontal inflammation. Approach Results—...
The purpose of this study was to determine whether periodontal disease is associated with endothelial dysfunction and systemic inflammation. Epidemiological studies suggest that severe increased cardiovascular risk, but the mechanisms remain unknown.We assessed flow-mediated dilation nitroglycerin-mediated brachial artery using vascular ultrasound in 26 subjects advanced 29 control subjects. groups were matched for age sex, patients hypercholesterolemia, diabetes mellitus, hypertension,...
Background: In the Periodontitis and Vascular Events (PAVE) pilot study, periodontal therapy was provided as an intervention in a secondary cardiac event prevention model through five coordinated cardiac–dental centers. Methods: Subjects were randomized to either community care or protocol scaling root planing evaluate effects on status systemic levels of high‐sensitivity C‐reactive protein (hs‐CRP). Results: After 6 months, there significant reduction mean probing depth extent 4‐ 5‐mm...
Periodontitis is an inflammatory condition of tooth-supporting tissues that usually treated by mechanical removal plaque and microorganisms adhere to teeth. This treatment, known as scaling root planing, not optimally effective. Adjunctive therapy with locally delivered antimicrobials has resulted in improved clinical outcomes such probing depth reduction. article reports on the efficacy safety administered microencapsulated minocycline.Seven hundred forty-eight (748) patients moderate...
ABSTRACT During infection, circulating blood monocytes migrate from the vasculature to extravascular compartments where they mature into tissue macrophages. The maturation process prepares cell actively participate in inflammatory and immune responses, many transcription factors have been found be involved. Here we report on a novel role for nuclear factor κB (NF-κB) this process. Its accumulation cytoplasm of differentiated macrophages is responsible enhanced ability respond...