A5054926688- Seaweed-derived Bioactive Compounds
- Marine and coastal plant biology
- Algal biology and biofuel production
- Echinoderm biology and ecology
- Marine Sponges and Natural Products
- Aquaculture Nutrition and Growth
- Polysaccharides and Plant Cell Walls
- Enzyme Production and Characterization
- Hemostasis and retained surgical items
- Proteoglycans and glycosaminoglycans research
- Protein Hydrolysis and Bioactive Peptides
- Neuropeptides and Animal Physiology
- Food Industry and Aquatic Biology
- Microbial Metabolites in Food Biotechnology
- Blood Coagulation and Thrombosis Mechanisms
- Botanical Research and Applications
- Food and Agricultural Sciences
- Phytochemical and Pharmacological Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Protease and Inhibitor Mechanisms
- Bone Metabolism and Diseases
- Phytochemistry and Bioactive Compounds
- Enzyme Catalysis and Immobilization
- Pain Mechanisms and Treatments
- Polysaccharides Composition and Applications
Universidade Federal do Ceará
2014-2025
Universidade Federal do Rio Grande do Sul
2021
Univates
2021
United Food and Commercial Workers
2017
École Polytechnique Fédérale de Lausanne
2015
Fundação Oswaldo Cruz
2012
Universidade Estadual do Ceará
2005-2011
Brazilian Biosciences National Laboratory
2009
Universidade Federal do Rio Grande do Norte
2009
Considering the use of commercials carrageenans as a model for inflammation, aim this work is comparative study these compounds in pro-inflammatory action by ear edema and pleurisy to analyze their anticoagulant activity. Paw was induced injecting kappa, iota lambda saline solution into hind paw male Wistar rats (p < 0.05). The three types showed different volume pleural exudates, characterized fluid accumulation, large number neutrophils raised NO production 0.001). activated partial...
This study assessed the antioxidant, antimicrobial, anticancer and neuroprotective activities of kappa(k)-carrageenan isolated from red alga Hypnea musciformis (Hm-SP). The chemical spectrum k-carrageenan Hm-SP was confirmed by Fourier transform infrared (FT-IR) spectroscopy. revealed an antibacterial antifungal action against Staphylococcus aureus Candida albicans, respectively. did not promoted cytotoxic effects Human breast cancer (MCF-7) neuroblastoma (SH-SY5Y) cell-lines. However, it...
The anti-inflammatory mechanisms of the sulfated polysaccharidic fraction obtained from red marine alga Gracilaria cornea (Gc-FI) were investigated using a paw edema model induced in rats by different inflammatory agents (carrageenan, dextran, serotonin, bradykinin, compound 48/80 or L-arginine). Gc-FI at doses 3, 9 27 mg/kg, subcutaneously - s.c., significantly inhibited rat carrageenan and as confirmed myeloperoxidase Evans’ blue assessments, respectively. (9 s.c.) histamine, L-arginine....
Summary We compared sulfated galactans (SGs) from two species of red algae using specific coagulation assays and experimental models thrombosis.These polysaccharides have an identical saccharide structure the same size chain, but with slight differences in their sulfation patterns.As a consequence these differences, SGs differ anticoagulant venous antithrombotic activities.SG G.crinale exhibits procoagulant prothrombotic effects low doses (up to 1.0 mg/kg body weight), high (>1.0 mg/kg)...
The aim of this study was to determine the yield, chemical composition, specific rotation (SR), infrared (IR) spectroscopy and effect on bacterial growth a crude sulfated polysaccharide (SP) from red marine alga G. ornata (Go). Go-1 (25°C), Go-2 (80°C), Go-3 (80°C) were sequentially extracted yielded 9.2%. contents sulfate (5.88-10.3%) proteins (0.1-3.7%) small. values SR [µ]D20°f -19.0, -51.0, -56.5, respectively. IR spectrums showed presence galactose-4 absence 3,6-anydrogalactose-2...
This work reports the effects of a sulfated polysaccharide (SP-Sf), isolated from seaweed Solieria filiformis and characterized by Fourier transformed infrared (FT-IR), on nociception inflammation. Male Swiss mice were pretreated with SP-Sf 30 min before receiving an injection 0.8% acetic acid, 1% formalin or prior to thermal stimulus. We observed that (1, 3 9 mg/kg) significantly reduced number writhes. also second phase test did not cause significant antinociceptive effect in hot plate...
Abstract: Seaweeds have attracted special interest as good sources of sulphated polysaccharides (SP) for use in pharmaceutical industries and biotechnology. In this study, we evaluated the effects SP from red seaweed Gracilaria cornea (Gc‐TSP) nociceptive inflammatory models. mice, Gc‐TSP (3, 9 or 27 mg/kg) significantly reduced responses, measured by number writhes, at all tested doses. a formalin test, licking time both phases test dose mg/kg. hot‐plate antinociceptive effect was observed...
Researchers see algae as a promising tool to discover both efficient and safe agents for pain therapy. We evaluated the antinociceptive anti-inflammatory activities of lectin from marine alga Pterocladiella capillacea (PcL). PcL was purified tested in classical models nociception inflammation. Male Swiss mice received 30 min prior receiving 0.8% acetic acid (10 microl/10 g, i.p.), 1% formalin (20 microl/intraplantar) or hot plate test, were compared untreated animals pretreated with...
The search for new compounds controlling pain and inflammation, with minimal side effects has focused on marine algae. aim of this work was to investigate the effect purified lectin from green alga Caulerpa cupressoides (CcL) in classical models nociception inflammation. Male Swiss mice received i.v. CcL 30 min prior receiving 0.8% acetic acid (10 ml/kg; i.p); 1% formalin (20 microl; s.c.) or were subjected thermal stimuli. We observed that (3, 9 27 mg/kg) significantly reduced number...
We investigated structural features of polysaccharides from Ulva lactuca and their effects on the classical models nociception inflammation. Crude extract was obtained by enzymatic digestion isolated ion exchange chromatography DEAE-cellulose. The fraction with higher yield used in tests (SP-Ul). Swiss mice received SP-Ul (1, 3 or 9mg/kg; i.v.), 30min prior to injection 0.8%-acetic acid 1%-formalin a thermal stimulus. At same doses, tested Wistar rats paw edema elicited different irritants...
Abstract Parkinson's disease (PD) is a multifactorial associated with the degeneration of dopaminergic neurons and behavioural alterations. Natural bioactive compounds may provide new therapeutic alternatives for neurodegenerative disorders, such as PD. The sulphated polysaccharides isolated from marine algae are heterogenic molecules that show different biological activities. red alga Gracilaria cornea has polysaccharide (SA‐Gc) structure anti‐inflammatory antinociceptive activities...
Seaweed lectins have been widely investigated as anti-nociceptive and anti-inflammatory agents. This study analyzed the responses of a lectin from green seaweed Caulerpa cupressoides (CcL) on zymosan-induced arthritis rat temporomandibular joint (TMJ). Rats received i.v. CcL 30 min prior to injection zymosan (2 mg/art.) or 0.9% saline into left TMJ. Mechanical hyper-nociception was measured by electronic von Frey method at baseline 4 h after injection. Animals were euthanized 6 synovial...
This study aimed at evaluating the antidepressant-like action of marine alga Solieria filiformis lectin (SfL) and to investigate participation monoaminergic system in this action. For this, male Swiss mice (n=10) were pretreated with intravenous injections (i.v.) SfL (1, 3 or 9mg/kg) submitted open field (OFT), tail suspension (TST), forced swimming (FST), elevated plus-maze (EPMT) hole-board tests (HBT). As controls, received sterile saline (i.v.), imipramine (10 30mg/kg; intraperitoneally...
Red algae sulfated polysaccharides (SPs) have been widely described as anticoagulant and antithrombotic agents; however no description of activity regarding green SPs has reported. Caulerpa cupressoides (Chlorophyta) three different fractions (SP1, SP2 SP3). We investigated the effects on thrombin by antithrombin in an experimental model venous thrombosis rats. The inhibition assay was evaluated using (AT) presence rats with thromboplastin thrombogenic stimulus. are suggested be due to...
A lectin isolated from the red alga Solieria filiformis was evaluated for its effect on growth of 8 gram-negative and 3 gram-positive bacteria cultivated in liquid medium (three independent experiments/bacterium). The (500 µg/mL) stimulated species Bacillus cereus inhibited Serratia marcescens, Salmonella typhi, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus sp, Pseudomonas aeruginosa at 1000 µg/mL but (10-1000 had no Staphylococcus aureus B. subtilis, or Escherichia coli...