A5101610387- Polysaccharides and Plant Cell Walls
- Biological Stains and Phytochemicals
- Botanical Research and Applications
- Wound Healing and Treatments
- Plant-Derived Bioactive Compounds
- Natural Antidiabetic Agents Studies
- Polysaccharides Composition and Applications
- Natural product bioactivities and synthesis
- Phytochemistry Medicinal Plant Applications
- Neuroscience and Neuropharmacology Research
- Carbohydrate Chemistry and Synthesis
- Insect and Arachnid Ecology and Behavior
- Glycosylation and Glycoproteins Research
- Insect and Pesticide Research
- Pharmacological Effects of Natural Compounds
- NF-κB Signaling Pathways
- Phytochemistry and biological activities of Ficus species
- Phytochemistry and Bioactive Compounds
- Phytochemicals and Medicinal Plants
- Traditional and Medicinal Uses of Annonaceae
- Ethnobotanical and Medicinal Plants Studies
- Vitamin K Research Studies
- Plant Toxicity and Pharmacological Properties
- Biochemical Analysis and Sensing Techniques
- Blood Coagulation and Thrombosis Mechanisms
Universidade Estadual do Ceará
2012-2024
Universidade Federal do Ceará
2004-2023
Centro Universitário Católica de Quixadá
2018-2023
Central State University
2020
Universidade do Estado de Mato Grosso
2019
Summary We compared sulfated galactans (SGs) from two species of red algae using specific coagulation assays and experimental models thrombosis.These polysaccharides have an identical saccharide structure the same size chain, but with slight differences in their sulfation patterns.As a consequence these differences, SGs differ anticoagulant venous antithrombotic activities.SG G.crinale exhibits procoagulant prothrombotic effects low doses (up to 1.0 mg/kg body weight), high (>1.0 mg/kg)...
Plant polysaccharides have biological activities in the brain and those obtained from Genipa americana leaves present antioxidant anticonvulsant effects mice model of pentylenetetrazole (PTZ)-induced acute seizures. This study aimed to evaluate polysaccharide-rich extract (PRE-Ga) models seizures chronic epilepsy (kindling) induced by PTZ. In seizure model, male Swiss (25–35 g) received PRE-Ga (1 or 9 mg/kg; intraperitoneal- IP), alone associated with diazepam (0.01 mg/kg), 30 min before...
Background and Objective: Diabetes decreases glucose metabolism, leading to hyperglycemia delayed wound healing.Caesalpinia ferrea or Libidibia (Fabaceae), popularly known as "pau ferro", "jucá" "jucaína", is widely used in folk medicine for inflammatory conditions.Caesalpinia barks are the form of tea portions clean injuries treat wounds its stem infusion enterocolitis, asthma, bruises, chronic cough wounds.This study aimed investigate effect polysaccharide-rich extract C. (PE-Cf) model...
Polysaccharides were extracted from the barks of Geoffroea spinosa, purified using anion exchange chromatography and characterized by chemical methylation analysis, complemented infrared NMR spectroscopies. These polysaccharides tested for their anticoagulant, antithrombotic antiplatelet activities also effects on bleeding. Unfractionated polysaccharide contains low levels protein high carbohydrate (including hexuronic acid). The (fractions FII FIII) are composed arabinose (Ara), rhamnose...
The parts of the Genipa americana (Rubiaceae) tree, also known as “jenipapo” or “jenipapeiro”, has been used in traditional Medicine parasitic and bacterial infections. Thus, experimental evolution antiparasitic activity polysaccharide extracts from leaves, correlation with popular use is important. To evaluate effect extract obtained leaves on all Trypanosoma cruzi (Y strain: benznidazole-resistant) developmental forms, a protozoan that causes Chagas’ disease. An rich polysaccharides was...
Azadirachta indica A. Juss., Meliaceae, or Indian neem is a plant used to treat inûammatory disorders. Total polysaccharide (TPL) and FI (fractioned by ion exchange chromatography) from the seed tegument of were evaluated in models acute inflammation (paw edema/peritonitis) using Wistar rats. Paw edema (measured hydroplethysmometry) was induced s.c. Λ-carrageenan (300 µg), histamine (100 serotonin (20 compound 48/80 (10 prostaglandin (PGE2 30 µg) L-arginine (15 µg). Peritonitis (analyzed for...
A new galactose-specific lectin, named BBL, was purified from seeds of Bauhinia bauhinioides by precipitation with ammonium sulfate, followed two steps ion exchange chromatography. BBL haemagglutinated rabbit erythrocytes (native and treated proteolytic enzymes) showing stability even after exposure to 60 °C for one hour. The lectin haemagglutinating activity optimum between pH 8.0 9.0 inhibited incubation D-galactose its derivatives, especially α-methyl-D-galactopyranoside. pure protein...
Ximenia americana L., Olacaceae, barks are utilized in folk medicine as analgesic and anti-inflammatory. The objective was to evaluate the toxicity antinociceptive effect of polysaccharides rich fractions from X. barks. were obtained by extraction with NaOH, followed precipitation ethanol fractionation ion exchange chromatography. They administered i.v. or p.o. before nociception tests (writhing, formalin, carragenan-induced hypernociception, hot plate), during 14 days for assay. total...
Abstract This study aimed to investigate the anti‐inflammatory and wound healing effects of polysaccharide extract from Opuntia ficus‐indica cladodes (TPL‐Ofi) using a rat cutaneous model. After anaesthesia, four 7‐mm‐diameter dorsal wounds per animal ( n = 6/group for each experimental day evaluation) were created in female Wistar rats surgical punch. The animals treated topically twice daily with TPL‐Ofi (0.01–1%; group) or sterile saline (control period 21 days. Ulcerated tissue was...
A lectina da alga marinha vermelha Vidalia obtusiloba foi purificada através combinação de precipitação com sulfato amônio, cromatografia troca iônica em DEAE-celulose e afinidade goma guar reticulada. preferencialmente aglutinou eritrócitos do grupo humano O, nativos tratados bromelaina. atividade hemaglutinante revelou que a era dependente cátions divalentes (Ca++ ou Mn++) inibida por N-acetil-galactosamina, D-galactosamina, alfa-lactose and D-galactose pela glicoproteína mucina estômago...
The South American giant ant, Dinoponera quadriceps (Hymenoptera, Formicidae, Ponerinae), produces proteinaceous venom that has antinociceptive, neuroprotective and antimicrobial effects, thereby supporting the popular use of these ants to treat asthma, rheumatism, earache back pain. Anticoagulant activity is another biological property been shown for other hymenopteran species, like wasps. aim this study was assess anti-inflammatory, anticoagulant antiplatelet properties D. (DqV). DqV...
The current study evaluated the effect of arabinogalactan-glycoconjugate fractions (FI and FII) isolated from Genipa americana leaves given per oral in rat hemostasis protocols. Rats received daily treatment with FI or FII during 7 days were for coagulation, platelet aggregation, venous thrombosis bleeding tendency 1 h after last treatment. prolonged 5.5-fold plasma coagulation time (activated partial thromboplastin test). inhibited by 46% aggregation. Both prevented thrombus formation 33...
Abstract Lectins are a group of proteins non‐immune origin recognized for their ability to bind reversibly carbohydrates. Researchers have been intrigued by oligosaccharides and glycoconjugates involvement as mediators complex cellular events then many biotechnological applications lectins based on glycocode decoding activities. Here, we report structural biological study ConA‐like mannose/glucose‐specific lectin from Canavalia bonariensis seeds, CaBo. More specifically, evaluate the binding...
Mimosa tenuiflora (Mimosaceae) or "jurema-preta" is well distributed in the northeast Brazil, being popularly used to treat skin lesions, burns and inflammation. The healing effect of alcoholic extract prepared with its barks corroborates popular use. This study aimed evaluate inflammatory response polysaccharides extracted from M. (EP-Mt) by methanol/NaOH ethanol precipitation. Inflammatory activity was assessed rat models acute inflammation (paw edema peritonitis), following parameters:...