A5083053305- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Antifungal resistance and susceptibility
- Pancreatitis Pathology and Treatment
- Immunotherapy and Immune Responses
- Fungal Infections and Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immune Cell Function and Interaction
- Nail Diseases and Treatments
- Inhalation and Respiratory Drug Delivery
- Maternal and Neonatal Healthcare
- Reproductive Health and Contraception
- Endoplasmic Reticulum Stress and Disease
- Gestational Diabetes Research and Management
- bioluminescence and chemiluminescence research
- Healthcare Regulation
- Dendrimers and Hyperbranched Polymers
- Autophagy in Disease and Therapy
- Reproductive tract infections research
- Syphilis Diagnosis and Treatment
- Skin Protection and Aging
- Advanced Glycation End Products research
- Pharmacological Effects of Natural Compounds
- Indigenous Health and Education
Universidade de Brasília
2018-2024
Ministério da Saúde
2024
Photodynamic therapy (PDT) has been clinically employed to treat mainly superficial cancer, such as basal cell carcinoma. This approach can eliminate tumors by direct cytotoxicity, tumor ischemia, or triggering an immune response against cells. Among the immune-related mechanisms of PDT, induction immunogenic death (ICD) in target cells is be cited. ICD apoptosis modality distinguished emission damage-associated molecular patterns (DAMP). Therefore, this study aimed analyze immunogenicity...
Diets rich in omega-3 or -6 fatty acids will produce different profiles for cell membranes phospholipid constitutions. Omegas 3 and 6 are part of the diet can modulate inflammatory profile. We evaluated effects oral absorption fish oil, when associated with a lipid nanoemulsion an experimental pulmonary model. Pulmonary fibrosis is disease excessive extracellular matrix deposition. determined to investigate morphophysiological mechanisms mice that were pretreated after induction bleomycin...
To improve the oral absorption of fish oil and test its anti-inflammatory effect, a nanoemulsion was developed using cis-4,7,10,13,16,19-docosahexaenoic fatty acid as biomarker for administration. The colloidal stability tests showed an average size 155.44 nm ± 6.46 (4 °C); 163.04 9.97 (25 °C) polydispersity index 0.22 0.02 °C), 0.21 indicating systems with low stable droplets. did not alter cell viability RAW 264.7 macrophages and, at concentration 0.024 mg/mL, kinetically incorporated into...
Melanoma, the most aggressive form of skin cancer, presents a major clinical challenge due to its tendency metastasize and recalcitrance traditional therapies. Despite advances in surgery, chemotherapy, radiotherapy, outlook for advanced melanoma remains bleak, reinforcing urgent need more effective treatments. Photodynamic therapy (PDT) has emerged as promising alternative, leading targeted tumor destruction with minimal harm surrounding tissues. In this study, direct abscopal antitumor...
The use of photodynamic therapy (PDT) and development novel photosensitizers (PSs) for cancer treatment have received more attention nowadays. In the present work, five benzo[a]phenoxazinium derivatives been prepared evaluated their in vitro anticancer activity first time. They are red light absorbers show low fluorescence quantum yield. Of these compounds, PS4 exhibited a higher yield reactive oxygen species (ROS) generation. assays with cells showed that PS1 were not significantly toxic...
The efficacy and safety of photodynamic therapy (PDT) have drawn much attention from clinicians researchers in the field anticancer treatments since last century. Despite numerous positive outcomes, works on PDT brought to light over decades, room remains for improvements tools, mainly photosensitizer molecules. This work reports first experiments evidencing photosensitizing activity DHX-1, a xanthene derivative-based near-infrared probe recently described literature, both as free molecule...
Idiopathic pulmonary fibrosis (IPF) is a progressive, relentless, and deadly disease. Little known about its pathogenetic mechanisms; therefore, developing efficient pharmacological therapies challenging. This work aimed to apply therapeutic alternative using immunomodulatory peptides in chronic murine model. BALB/c mice were intratracheally instilled with bleomycin (BLM) followed for 30 days. The treated the immune modulatory ToAP3 ToAP4 every three days, starting on 5th day post-BLM...
Different stressors of the endoplasmic reticulum (ER) can trigger immunogenic cell death (ICD), a modality regulated that be therapeutically used to induce antitumor immune responses. Curcumin has been pointed out as an ER stressor, but its potential activity ICD inducer not studied. Thus, goal this work was investigate whether curcumin triggers in murine colorectal carcinoma CT26 cells vitro. The results show treated with underwent apoptosis and exposed damage-associated molecular patterns,...
This study aimed to know the opinion of professionals participating in an experiment implement a pilot for molecular tests detect Chlamydia trachomatis and Neisseria gonorrhoeae at Brazilian Unified National Health System (SUS). The detection rate C. and/or N. factors associated with infection were determined. strategy included laboratories belonging HIV viral hepatitis load network. Testing targeted people who are more vulnerable sexually transmitted infections collected urine samples...
Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance, with a decrease in insulin sensitivity during pregnancy, recognition the second or third trimester pregnancy and disappearing after delivery. This mini-review to provide broad view some recent studies that investigated placental morphology cases maternal diagnosis gestational diabetes. A literature search was carried out PubMed, Medline, Google Scholar data sources, verifying morphological characteristics...