A5030662468- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Immunotherapy and Immune Responses
- Porphyrin and Phthalocyanine Chemistry
- RNA Interference and Gene Delivery
- Advancements in Transdermal Drug Delivery
- Fungal Infections and Studies
- Nanoparticles: synthesis and applications
- Advanced Drug Delivery Systems
- Selenium in Biological Systems
- Synthesis and biological activity
- Antifungal resistance and susceptibility
- Fatty Acid Research and Health
- Lipid Membrane Structure and Behavior
- Skin Protection and Aging
- Cancer Immunotherapy and Biomarkers
- Laser Applications in Dentistry and Medicine
- Nail Diseases and Treatments
- Curcumin's Biomedical Applications
- Moringa oleifera research and applications
- Advanced biosensing and bioanalysis techniques
- Phytochemical compounds biological activities
- Essential Oils and Antimicrobial Activity
- Protein Interaction Studies and Fluorescence Analysis
Universidade de Brasília
2016-2025
Universidade Federal do Paraná
2009-2011
Discovered in mid-1817 by Jöns Jacob Berzelius, selenium, belonging to Group 16 of the periodic table is an essential trace element for human and animal health, due its biocompatibility bioavailability. Additionally, it known having different oxidation states, which allows interact with distinct chemical elements form various compounds. Selenium exhibits two forms, organic inorganic; latter genotoxicity. nanoparticles have been investigated as alternative mitigate toxicity this element. With...
Background: Paullinia cupana Kunth, popularly known as guarana, a native Amazonian shrub cultivated by the Sateré-Mawé ethnic group, has been used in traditional medicine for various purposes, including stimulant and therapeutic actions, due to its chemical composition, which is rich bioactive compounds. This study explored reductive potential of guarana with nanobiotechnology aimed synthesize silver nanoparticles (AgNPs) using aqueous extract leaves collected during dry rainy seasons,...
Selenium nanoparticles (SeNPs) have attracted increasing interest over the last decades because of their activities on redox balance in human body. However, SeNPs tend to aggregate into large clusters, resulting lower bioactivity, bioavailability and biocompatibility. Surface-capping agents play crucial roles its stabilization biological activity. Here, a green synthesis method for preparation Lycium barbarum polysaccharides capped using tea extracts as reductants under mild conditions, at...
Photodynamic therapy (PDT) combines light, molecular oxygen and a photosensitizer to induce oxidative stress in target cells. Certain hydrophobic photosensitizers, such as aluminium-phthalocyanine chloride (AlPc), have significant potential for antitumor PDT applications. However, molecules often require drug-delivery systems, nanostructures, improve their pharmacokinetic properties prevent aggregation, which has quenching effect on the photoemission aqueous media. As result, this work aims...
Abstract: Photodynamic therapy is generally considered to be safer than conventional anticancer therapies, and it effective against different kinds of cancer. However, its clinical application has been significantly limited by the hydrophobicity photosensitizers. In this work, a system composed hydrophobic photosensitizer aluminum–phthalocyanine chloride (AlPc) associated with water dispersible poly(methyl vinyl ether-co-maleic anhydride) nanoparticles described. AlPc was produced method...
Photodynamic therapy (PDT) has been clinically employed to treat mainly superficial cancer, such as basal cell carcinoma. This approach can eliminate tumors by direct cytotoxicity, tumor ischemia, or triggering an immune response against cells. Among the immune-related mechanisms of PDT, induction immunogenic death (ICD) in target cells is be cited. ICD apoptosis modality distinguished emission damage-associated molecular patterns (DAMP). Therefore, this study aimed analyze immunogenicity...
A new Keap1-Nrf2 protein-protein interaction (PPI) inhibitor ZJ01 was identified from our compound library by fluorescence polarization assay, surface plasmon resonance, molecular docking and dynamics simulation. could in vitro trigger Nrf2 nuclear translocation, subsequently resulting increased mRNA levels of target genes HO-1 NQO1. Meanwhile, suppressed LPS-induced production ROS the pro-inflammatory cytokines TNF-α, IL-1β IL-6 H9c2 cardiac cells. Moreover, an vivo mouse model septic...
Photodynamic therapy (PDT) mediated by photosensitizers loaded in nanostructures as solid lipid nanoparticles has been pinpointed an effective and safe treatment against different skin cancers. Amazon butters have interesting composition when it comes to forming (SLN). In the present report, a new third-generation photosensitizing system consisting of aluminum-phthalocyanine associated with butter-based (SLN-AlPc) is described. The SLN was developed using murumuru butter, monodisperse...
The green synthesis of silver nanoparticles (AgNPs) can be developed using safe and environmentally friendly routes, replace potentially toxic chemical methods, increase the scale production. This study aimed to synthesize AgNPs from aqueous extracts guarana (Paullinia cupana) leaves flowers, collected in different seasons year, as a source active biomolecules capable reducing ions (Ag+) promoting stabilization colloidal (Ag0). plant were characterized regarding their metabolic composition...
To develop an acid-sensitive lipidated, doxorubicin (Dox) prodrug (C16-Dox) to be entrapped in lipid nanoemulsion (NE-C16-Dox) as a nanocarrier treat breast cancer models (in vitro and vivo).We report the efficacy of NE-C16-Dox experiments, well improved chemotherapeutic index tumor-control compared with treatment free Dox vivo murine 4T1 model. In addition, allowed use higher dose Dox, acceptable biocompatibility significant reduction lung metastasis.Taken together, these results indicate...
Schistosomiasis is a disease caused by parasites of the genus Schistosoma, currently affecting more than 200 million people. Among various species this parasite that infect humans, S. mansoni most common. Pharmacological treatment limited to use single drug, praziquantel (PZQ), despite reports resistance and low efficacy. It therefore necessary investigate new potential schistosomicidal compounds. In study, we tested efficacy epiisopilosine (EPIIS) in murine model schistosomiasis. A dose...
To develop a self-nanoemulsifying drug-delivery system (SNEDDS) able to improve oral absorption of epiisopiloturine (EPI), and test the antischistosomal activity in mice model.SNEDDS had nanoscopic size was enhance EPI bioavailability after administration, SNEDDS-EPI (40 mg.kg-1) improved vivo EPI, demonstrating that SNEDDS pharmacokinetics maintain pharmacodynamic against Schistosoma mansoni vivo.Taken together, these results indicate is efficient reducing worm burden comparison treatment...