A5074717380- COVID-19 Clinical Research Studies
- Neuroscience and Neuropharmacology Research
- Adipose Tissue and Metabolism
- Neurotransmitter Receptor Influence on Behavior
- Pain Mechanisms and Treatments
- Nerve injury and regeneration
- SARS-CoV-2 and COVID-19 Research
- RNA and protein synthesis mechanisms
- Seaweed-derived Bioactive Compounds
- Pancreatitis Pathology and Treatment
- Regulation of Appetite and Obesity
- Essential Oils and Antimicrobial Activity
- Biochemical Analysis and Sensing Techniques
- Long-Term Effects of COVID-19
- Complement system in diseases
- Oral health in cancer treatment
- Polysaccharides and Plant Cell Walls
- Phytochemistry and Biological Activities
- Pancreatic and Hepatic Oncology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Microbial Metabolites in Food Biotechnology
- Echinoderm biology and ecology
- Olfactory and Sensory Function Studies
- Stress Responses and Cortisol
Universidade de São Paulo
2021-2025
Universidade de Ribeirão Preto
2025
Universidade Federal do Ceará
2014-2024
Universidade Federal de Minas Gerais
2016-2023
Universidad de Salamanca
2020
Universidade Federal do Espírito Santo
2014
Universidade Federal do Piauí
2012-2013
Abstract Studies have shown that diterpenes anti‐inflammatory and redox‐protective pharmacological activities. The present study aimed to investigate the properties of phytol, a diterpene alcohol, in mouse model acute inflammation, phytol effect on leukocyte recruitment, cytokines levels, oxidative stress. activities were assessed by measuring paw edema induced different inflammatory agents (e.g., λ‐carrageenan, compound 48/80, histamine, serotonin, bradykinin, prostaglandin E 2 [ PGE ]),...
Occurrence of hyperglycemia upon infection is associated with worse clinical outcome in COVID-19 patients. However, it still unknown whether SARS-CoV-2 directly triggers hyperglycemia. Herein, we interrogated and how causes by infecting hepatocytes increasing glucose production. We performed a retrospective cohort study including patients that were admitted at hospital suspicion COVID-19. Clinical laboratory data collected from the chart records daily blood values analyzed to test hypothesis...
Resident macrophages are distributed across all tissues and highly heterogeneous due to adaptation different tissue-specific environments. The resident of the sensory ganglia (sensory neuron-associated macrophages, sNAMs) in close contact with cell body primary neurons might play physiological pathophysiological roles. After peripheral nerve injury, there is an increase population ganglia, which have been implicated conditions, including neuropathic pain development. However, it still under...
The aim of this study was to investigate the antinociceptive and anti-inflammatory activities epiisopiloturine (1), an imidazole alkaloid found in leaves Pilocarpus microphyllus. activity 1 evaluated using several agents that induce paw edema peritonitis Swiss mice. Paw tissue peritoneal fluid samples were obtained determine myeloperoxidase (MPO) or tumor necrosis factor (TNF)-α interleukin (IL)-1β levels. by acetic acid-induced writhing, hot plate test, pain induction formalin. Compared...
ABSTRACT Preclinical Research Long‐term use nonsteroidal anti‐inflammatory drug is associated with gastrointestinal (GI) lesion formation. The aim of this study was to investigate the protective activity cashew gum (CG), a complex heteropolysaccharide extracted from Anacardium occidentale on naproxen (NAP)‐induced GI damage. Male Wistar rats were pretreated vehicle or CG (1, 3, 10, and 30 mg/kg, p.o.) twice daily for 2 days; after 1 h, NAP (80 administered. euthanized 2nd day treatment, 4 h...
Abstract Introduction Maternal separation is an early life stress event associated with behavioral alterations and ethanol consumption. We aimed to expand the current understanding on molecular mechanisms mediating impact of postnatal Methods In first experiment (T1), some pups were separated from their mothers for 6 hr daily (Maternal Separation group ‐ MS ), whereas other remained in cage respective (Control C). second (T2), mice both groups subjected model free‐choice between water...
There are currently relatively few small-molecule antiviral drugs that either approved or emergency-approved for use against severe acute respiratory coronavirus 2 (SARS-CoV-2). One of these is remdesivir, which was originally repurposed from its Ebola. We evaluated three molecules we had previously identified computationally with activity Ebola and Marburg pyronaridine, inhibited the SARS-CoV-2 replication in A549-ACE2 cells. The vivo efficacy pyronaridine has now been assessed a K18-hACE...
Patients with severe COVID-19 develop acute respiratory distress syndrome (ARDS) that may progress to cytokine storm syndrome, organ dysfunction, and death. Considering complement component 5a (C5a), through its cellular receptor C5aR1, has potent proinflammatory actions plays immunopathological roles in inflammatory diseases, we investigated whether the C5a/C5aR1 pathway could be involved pathophysiology. signaling increased locally lung, especially neutrophils of critically ill patients...
The aim of the study was to investigate anti-inflammatory, antioxidant and antinociceptive actions PFPe, a polysaccharide fraction isolated from dried fruit Passiflora edulis.Animals were pretreated with PFPe (0.3, 1 or 3 mg/kg, i.p.) h before induction paw oedema by carrageenan, histamine, serotonin, compound 48/80 prostaglandin E2 (PGE2). Neutrophil migration vascular permeability measured after carrageenan injection into peritoneum, action on tumour necrosis factor-alpha, interleukin-1...
Red seaweeds synthesize a great variety of sulfated galactans. Sulfated polysaccharides (PLSs) from seaweed are comprised substances with pharmaceutical and biomedical potential. The aim the present study was to evaluate protective effect PLS fraction extracted Gracilaria birdiae in rats naproxen-induced gastrointestinal damage. Male Wistar were pretreated 0.5% carboxymethylcellulose (control group—vehicle) or (10, 30, 90 mg/kg, p.o.) twice daily (at 09:00 21:00) for 2 days. After 1 h,...
Our objective was to investigate the protective effect of Lawesson's reagent, an H2S donor, against alendronate (ALD)-induced gastric damage in rats. Rats were pretreated with saline or reagent (3, 9, 27 µmol/kg, po) once daily for 4 days. After 30 min, induced by ALD (30 mg/kg) administration gavage. On last day treatment, animals killed h after administration. Gastric lesions measured using a computer planimetry program, and corpus pieces assayed malondialdehyde (MDA), glutathione (GSH),...
Lactobacillus spp. and Bifidobacterium was used to protect against gastrointestinal disorders. The present study evaluated the effects of probiotic mixture (PM) containing on intestinal mucositis induced by 5-fluorouracil (5-FU). Swiss male mice (25–30 g) were treated with 5-FU (450 mg/kg, ip) orally administered (PM). Probiotic 1 (PM-1) is a two probiotics (Lactobacillus acidophilus lactis) 2 (PM-2) four acidophilus, paracasei, rhamnosus, lactis). PM-1 PM-2 decreased histopathological...
Chikungunya virus (CHIKV), the causative agent of chikungunya fever, is an alphavirus widely transmitted by bite female mosquito genus Aedes sp., especially in tropical and subtropical regions. Brazil country most affected microorganism. CHIKV classically induces articular pain, which can become long lasting for even years a great number infected individuals, reducing their quality life. The mechanisms CHIKV-induced pain are poorly understood, but recent evidence indicated role transient...
Summary Background Cutaneous leishmaniasis (CL) is characterized by immune dysregulation that facilitates chronic infection. Objective To investigate the role of T cells in immunopathology CL characterizing landscape skin lesions using single-cell RNA sequencing (scRNA-seq). Methods We performed scRNA-seq to profile from PBMC and patients. Results analyzed transcriptional distinct populations CD4+ CD8+ migratory lesions. resident displayed expression exhaustion markers were categorized into...
Seaweeds are the most abundant source of polysaccharides such as alginates and agar, well carrageenans. This study aimed to investigate gastroprotective activity mechanism underlying this a sulfated-polysaccharide fraction extracted from algae Hypnea musciformis (Wulfen) J.V. Lamour. (Gigartinales– Rhodophyta). Mice were treated with (3, 10, 30, 90 mg/kg, p.o.) and, after 30 min, they administered 50% ethanol (0.5 mL/25 g, p.o.). After 1 h, gastric damage was measured using planimeter. In...
The portfolio of SARS-CoV-2 small molecule drugs is currently limited to a handful that are either approved (remdesivir), emergency (dexamethasone, baricitinib, paxlovid, and molnupiravir), or in advanced clinical trials. Vandetanib kinase inhibitor which targets the vascular endothelial growth factor receptor (VEGFR), epidermal (EGFR), as well RET-tyrosine kinase. In current study, it was tested different cell lines showed promising results on inhibition versus toxic effect A549-hACE2 cells (IC
The Wistar Audiogenic Rat (WAR) and the Genetic Seizure Hamster from Salamanca (GASH/Sal) strains are audiogenic epilepsy models, in which seizures triggered by acoustic stimulation. These were developed selective reproduction have a genetic background with minimal or no variation. In current study, we evaluated transcriptome of inferior colliculus, epileptogenic nucleus, both order to get insights into common molecular aspects associated their epileptic phenotype. Based on GASH/Sal RNA-Seq...
The bidirectional and positive relation between the ingestion of fat alcohol has become subject extensive discussion. However, this is more studied in animal models binge eating with intermittent access high-fat diet or a model short period consumption. Here, we developed to elucidate how chronic its withdrawal influence intake (two-bottle choice) anxiety behavior (marble burying test). In first experimental stage, animals were fed on standard (AIN93G) high sugar butter (HSB) for 8 weeks....