A5081991330- COVID-19 Clinical Research Studies
- Helicobacter pylori-related gastroenterology studies
- Seaweed-derived Bioactive Compounds
- Gastroesophageal reflux and treatments
- Cardiac Ischemia and Reperfusion
- Polysaccharides and Plant Cell Walls
- SARS-CoV-2 and COVID-19 Research
- Eosinophilic Esophagitis
- Healthcare Regulation
- Cardiac electrophysiology and arrhythmias
- Ginkgo biloba and Cashew Applications
- Long-Term Effects of COVID-19
- Sulfur Compounds in Biology
- Microbial Metabolites in Food Biotechnology
- Dysphagia Assessment and Management
- Essential Oils and Antimicrobial Activity
- Oral health in cancer treatment
- Alcohol Consumption and Health Effects
- Healthcare during COVID-19 Pandemic
- Nitric Oxide and Endothelin Effects
- Phytochemistry and Bioactive Compounds
- Polysaccharides Composition and Applications
- Echinoderm biology and ecology
- Pharmacology and Obesity Treatment
- Therapeutic Uses of Natural Elements
Universidade Federal do Piauí
2011-2024
Universidade Federal do Delta do Parnaíba
2020-2024
Universidade Federal do Ceará
2015-2024
National Center for Genetic Engineering and Biotechnology
2024
Universidade Federal do Amazonas
2022
Queen Mary University of London
2019
Universidade de São Paulo
2017
Instituto Federal de Educação Ciência e Tecnologia do Paraná
2005
Many algal species contain relatively high concentrations of polysaccharide substances, a number which have been shown to anti-inflammatory and/or immunomodulatory activity. In this study, we evaluated the and antinociceptive effects in mice sulfated fraction (PLS) extracted from algae Gracilaria caudata. The antiinflammatory activity PLS was using several inflammatory agents (carrageenan, dextran, bradykinin, histamine) induce paw edema peritonitis Swiss mice. Samples tissue peritoneal...
ABSTRACT Preclinical Research Long‐term use nonsteroidal anti‐inflammatory drug is associated with gastrointestinal (GI) lesion formation. The aim of this study was to investigate the protective activity cashew gum (CG), a complex heteropolysaccharide extracted from Anacardium occidentale on naproxen (NAP)‐induced GI damage. Male Wistar rats were pretreated vehicle or CG (1, 3, 10, and 30 mg/kg, p.o.) twice daily for 2 days; after 1 h, NAP (80 administered. euthanized 2nd day treatment, 4 h...
Myracrodruon urundeuva (Engl.) Fr. All., commonly known as "aroeira-do-sertão", is a medicinal plant from Anacardiaceae family. In this study, the chemical composition of M. essential oil (MuEO) was evaluated by gas chromatography-mass spectrometry (GC-MS), well its anti-Leishmania potential, cytotoxicity, and macrophage activation capability possible antiprotozoal mechanism action were assessed. Fourteen compounds identified, which constituted 94.87% total composition. The most abundant...
Anacardic acid (AA), a compound extracted from cashew nut liquid, exhibits numerous pharmacological activities. The aim of the current investigation was to assess anti-inflammatory, antinociceptive, and antioxidant activities AA in mouse models. For this, Swiss albino mice were pretreated with (10, 25, 50 mg/kg, intraperitoneally, ip) 30 min prior administration carrageenan, as well 25 mg/kg prostaglandin E2, dextran, histamine, 48/80. antinociceptive activity evaluated by formalin,...
This study aimed to evaluate the role of pepsin inhibitors in inflammatory response and their effects on laryngeal mucosal integrity during gastroesophageal reflux (GERD) under vivo conditions.
The aim of the present study was to investigate gastroprotective activity a sulfated-polysaccharide (PLS) fraction extracted from marine red algae Gracilaria caudata and mechanism underlying activity. Male Swiss mice were treated with PLS (3, 10, 30 90 mg·kg(-1), p.o.), after min, they administered 50% ethanol (0.5 mL/25 g(-1), p.o.). One hour later, gastric damage measured using planimeter. Samples stomach tissue also obtained for histopathological assessment assays glutathione (GSH)...
Our objective was to investigate the protective effect of Lawesson's reagent, an H2S donor, against alendronate (ALD)-induced gastric damage in rats. Rats were pretreated with saline or reagent (3, 9, 27 µmol/kg, po) once daily for 4 days. After 30 min, induced by ALD (30 mg/kg) administration gavage. On last day treatment, animals killed h after administration. Gastric lesions measured using a computer planimetry program, and corpus pieces assayed malondialdehyde (MDA), glutathione (GSH),...
Our objective was to evaluate the role of soluble guanylate cyclase (sGC) activation in gastroprotective effect HO-1/CO pathway against alendronate-induced gastric damage rats. Rats were pretreated, once daily for 4 days, with saline, hemin (HO-1 inducer), or dimanganese decacarbonyl (DMDC, CO donor). Another group received zinc protoporphyrin IX (ZnPP IX, HO-1 antagonist) 1 h before treatment sGC inhibitor (ODQ) 30 min and DMDC treatment. After min, induced by alendronate (30 mg/kg) gavage....
Sideroxylon obtusifolium (Roem. & Schult.) T.D. Penn., Sapotaceae family, is a medicinal species native to the Brazilian Northeastern region. The plant popularly used as an anti-inflammatory and hypoglycemic.To evaluate properties of N-methyl-(2S,4R)-trans-4-hydroxy-l-proline (NMP) from S. leaves in models inflammation clarify its action mechanisms.Male Swiss mice were distributed intocontrols groups treated with NMP (25, 50 100mg/kg, p.o.), indomethacin or morphine (reference drugs)....
Anadenanthera colubrina var. cebil (Griseb.) Altschul (Fabaceae family), commonly known as the red angico tree, is a medicinal plant found throughout Brazil's semi-arid area. In this study, chemical analysis was performed to investigate antidiarrheal activity and safety profile of gum (RAG), biopolymer extracted from trunk exudate A. colubrina. Upon FT-IR spectroscopy, RAG showed bands in regions 1608 cm-1, 1368 1029 which relate vibration O-H water molecules, deformation C-O bands,...
Seaweeds are the most abundant source of polysaccharides such as alginates and agar, well carrageenans. This study aimed to investigate gastroprotective activity mechanism underlying this a sulfated-polysaccharide fraction extracted from algae Hypnea musciformis (Wulfen) J.V. Lamour. (Gigartinales– Rhodophyta). Mice were treated with (3, 10, 30, 90 mg/kg, p.o.) and, after 30 min, they administered 50% ethanol (0.5 mL/25 g, p.o.). After 1 h, gastric damage was measured using planimeter. In...
Diarrhoea is a significant health problem for children in developing countries that causes more than 1 million deaths annually. This study aimed to evaluate the antidiarrhoeal effect of sulphated polysaccharide (PLS) from alga Gracilaria caudata rodents. For evaluation, acute diarrhoea was induced Wistar rats (150-200 g) by administration castor oil (10 mg/kg). Then, different parameters, including enteropooling and gastrointestinal transit its pharmacological modulation opioid cholinergic...