A5050925249- Research on Leishmaniasis Studies
- Insect Pest Control Strategies
- Trypanosoma species research and implications
- Phytochemistry Medicinal Plant Applications
- Toxin Mechanisms and Immunotoxins
- Phytochemical compounds biological activities
- Bee Products Chemical Analysis
- Essential Oils and Antimicrobial Activity
- Mesenchymal stem cell research
- Nanocomposite Films for Food Packaging
- Tissue Engineering and Regenerative Medicine
- Synthesis and biological activity
- Insect and Pesticide Research
- Plant Toxicity and Pharmacological Properties
- Polysaccharides Composition and Applications
- 3D Printing in Biomedical Research
- Synthesis and Biological Evaluation
- Advanced Drug Delivery Systems
- Natural product bioactivities and synthesis
- Wound Healing and Treatments
- Traditional and Medicinal Uses of Annonaceae
- Nanoparticles: synthesis and applications
- Synthesis and Characterization of Heterocyclic Compounds
- Parasites and Host Interactions
- biodegradable polymer synthesis and properties
Universidade Federal do Piauí
2016-2025
Universidade Federal de Pernambuco
2024
Universidade Federal do Maranhão
2020
Universidade Federal do Rio de Janeiro
2016
Universidade Federal de Minas Gerais
2002
Bipar
2001
Leishmania amazonensis is one of the major etiologic agents a broad spectrum clinical forms leishmaniasis and has wide geographical distribution in Americas, which overlaps with areas transmission many other species. The LACK A2 antigens are shared by various was previously shown to induce potent Th1 immune response protection against L. donovani infection BALB/c mice. effective infection, but no significant observed, spite induction response. In an attempt select candidate for American...
Syzygium cumini (L.) Skeels (Myrtaceae), commonly known as "jambolão" in Brazil is widely used folk medicine against leishmaniasis, inflammation, chronic diarrhea, and ulcers. It one of the most plants for treatment diabetes worldwide. In previous studies, was shown to possess antihyperlipidemic anti-allergic properties, exhibit good performance an antimicrobial agent bacteria, fungi, protozoa parasites genus Leishmania Trypanosoma. This study aimed at evaluating effects S. essential oil...
A new hybrid bionanomaterial composed of zinc oxide nanoparticles (ZnO NPs) and chitosan was constructed after enzymatic immobilization papain for biomedical applications. In this work, we report the preparation characterization steps its biocompatibility in vitro. The properties immobilized system were investigated by transmission electron microscopy, zeta potential, DLS, UV–vis absorption spectroscopy, FTIR X-ray diffraction. prepared exhibited a nanotriangular structure with size 150 nm...
Eugenia uniflora L. is a member of the Myrtaceae family and commonly known as Brazilian cherry tree. In this study, we evaluated chemical composition essential oil (EuEO) by using gas chromatography-mass spectrometry (GC-MS) assessed its anti-Leishmania activity. We also explored potential mechanisms action cytotoxicity EuEO. Thirty-two compounds were identified, which constituted 92.65% total composition. The most abundant components sesquiterpenes (91.92%), with curzerene (47.3%), γ...
Gold (Au0) and silver (Ag0) nanoparticles were synthesized using tannic acid (TA) as both reducing stabilizer. Nanoparticles formation, stability, interaction with TA compared to citrate-coated monitored by UV-Vis, zeta potential, transmission electron microscopy. coating resulted in a red-shift broadening of bands (NPs-Cit). AgNPs-TA AuNPs-TA are negatively charged mean surface charge -29.4 mV -29.6 mV, respectively. TEM images showed polydispersety (6-42 nm) aggregation (12-71 nm). In...
Abstract Objectives The aim of this work was to investigate the antinociceptive property α-phellandrene (α-PHE) in experimental nociception models and possible mechanisms involved. Methods Mass spectrometry used evaluate purity molecular mass α-PHE. Macrophages from mice peritoneal cavity were an MTT test. Rodents tests chemical mechanical nociception. In study mechanisms, animals treated with pharmacological tools then submitted glutamate Key findings α-PHE 98.2% 136.1 Da. did not show...
The leishmaniases are severe parasitic diseases that occur worldwide, caused by protozoa of the genus Leishmania. Studies with medicinal plants can lead to a range possibilities for treating and improving patients' quality life. Research on Azadirachta indica fractions extracts has shown they have excellent anti-leishmanial activity based bioactivity-guided fractionation ethanolic leaves seeds in vitro against promastigotes. In this research most efficient were selected tests intracellular...
The chemical composition and biological potential of the essential oil extracted from Syzygium cumini leaves collected in Brazil were examined. GC/MS Analyses revealed a high abundance monoterpenes (87.12%) oil. Eleven compounds identified, with major components being α-pinene (31.85%), (Z)-β-ocimene (28.98%), (E)-β-ocimene (11.71%). To evaluate molluscicidal effect oil, it was tested against Biomphalaria glabrata LC₅₀ obtained 90 mg/l. also showed significant activity Leishmania...
Myracrodruon urundeuva (Engl.) Fr. All., commonly known as "aroeira-do-sertão", is a medicinal plant from Anacardiaceae family. In this study, the chemical composition of M. essential oil (MuEO) was evaluated by gas chromatography-mass spectrometry (GC-MS), well its anti-Leishmania potential, cytotoxicity, and macrophage activation capability possible antiprotozoal mechanism action were assessed. Fourteen compounds identified, which constituted 94.87% total composition. The most abundant...
Silver nanoparticles have been studied as an alternative for treatment of microbial infections and leishmaniasis, without promoting induction or parasite resistance. In this study, chitosan-based silver were synthesized from nitrate (AgNO 3 ), sodium borohydride a reducing agent, the biopolymer chitosan capping agent. The characterized by ultraviolet–visible, Fourier transform infrared, dynamic light scattering, zeta potential, atomic force microscopy, transmission electron microscope....
Leishmaniasis is an infectious disease complex caused by protozoa from the Leishmania genus, which presents a broad spectrum of clinical manifestations: cutaneous, mucocutaneous and visceral forms. The current treatments are unsatisfactory considering that few drugs available present some level toxicity. Many lignans neolignans have been used for development new antileishmania drugs. capability in vitro neolignan 2,3-dihydrobenzofuran (2,3-DBF), commonly found constituent propolis other...
Visceral leishmaniasis (VL) is almost always lethal if not treated, but most infections with the causative agents are clinically silent. Mannan-binding lectin (MBL), an opsonin, a candidate molecule for modifying progression to VL because it may enhance infection intracellular pathogens. Mutations in MBL2 gene decrease levels of MBL and protect against development VL. This case-control study examines genotypes individuals presenting different outcomes Leishmania chagasi.Genotypes serum were...
Hydrogels are structures that have value for application in the area of tissue engineering because they mimic extracellular matrix. Naturally obtained polysaccharides, such as chitosan (CH) and cashew gum, materials with ability to form polymeric networks due their physicochemical properties. This research aimed develop a scaffold based on phthalated tree gum test it support growth human mesenchymal stem cells. In this study, phthalation (PCG) was performed by using solvent-free route....
Background To evaluate the effect of insecticide spraying for vector control and elimination infected dogs on incidence human infection with L. infantum, a randomized community intervention trial was carried out in city Teresina, Brazil. Methods/Principal Findings Within each ten localities city, four blocks were selected to 4 interventions: 1) houses animal pens insecticide; 2) eliminating dogs; 3) combination dogs, 4) nothing. The main outcome is assessed by conversion Montenegro skin test...
Garcinielliptone FC (GFC), a natural prenylated benzophenone, was extracted from Platonia insignis Mart. (Clusiaceae), native plant commonly known as bacuri and used in traditional Brazilian medicine for the treatment of skin diseases. The aim this study to evaluate cytotoxic leishmanicidal effects GFC using vitro models. experimental data demonstrated that polyisoprenylated benzophenone possesses activities.
The "bacuri" (Platonia insignis Mart., Clusiaceae) is a native tropical fruit from the Brazilian Amazon and Northeast Regions. Its seeds are used to treat inflammatory diseases, diarrhea skin problems in traditional medical practices. Regarding its widespread medicinal uses, it important evaluate biological toxicological potential of this species. This way, aim study was investigate vitro cytotoxic immunomodulatory effects hexanic extract P. seeds, as well vivo acute oral toxicity....