A5003530843- Essential Oils and Antimicrobial Activity
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Cancer therapeutics and mechanisms
- Phytochemical compounds biological activities
- Research on Leishmaniasis Studies
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Pain Mechanisms and Treatments
- Toxin Mechanisms and Immunotoxins
- Sesquiterpenes and Asteraceae Studies
- Piperaceae Chemical and Biological Studies
- Plant biochemistry and biosynthesis
- Medicinal Plants and Neuroprotection
- Synthesis and Biological Evaluation
- Phytochemistry Medicinal Plant Applications
- Insect Pest Control Strategies
- Synthesis and Characterization of Heterocyclic Compounds
- Antioxidant Activity and Oxidative Stress
- Biochemical Analysis and Sensing Techniques
- Genetically Modified Organisms Research
- Drug Transport and Resistance Mechanisms
- Curcumin's Biomedical Applications
- biodegradable polymer synthesis and properties
- Dendrimers and Hyperbranched Polymers
Universidade Federal da Paraíba
2013-2025
Universidade Federal do Piauí
2017-2022
Ton Duc Thang University
2018
(−)-Carvone is a monoterpene ketone that the main active component of Mentha plant species like spicata. This study aimed to investigate antinociceptive activity (−)-carvone using different experimental models pain and whether such effects might be involved in nervous excitability elicited by others monoterpenes. In acetic acid-induced writhing test, we observed (−)-carvone-treated mice exhibited significant decrease number writhes when 100 200 mg/kg was administered. It also demonstrated...
Among the food additives used in industry, dyes are considered most toxic. For instance, tartrazine (TRZ) is a colorant commercially available with conflicting data regarding its cytotoxic, genotoxic, and mutagenic effects. Therefore, this study aimed to evaluate cytotoxic potential of TRZ using different eukaryotic cells (in vitro).This employed 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT), brine shrimp lethality, Allium cepa Saccharomyces cerevisiae tests....
Carvone (p-mentha-6,8-dien-2-one) is a monoterpene ketone found as the main active component of various essential oils. It obtained by distillation and occurs naturally enantiomers (+)- (−)-carvone. Our group have shown that in vivo antinociceptive activity (−)-carvone impaired with decreased nerve excitability. To better characterize neuropharmacology such monoterpene, we investigated profile several carvone analogues to establish structure–function relationship related compound action...
Essential oils are natural, complex and multi-component systems composed mainly of terpenes in addition to some other non-terpenes compounds that widely used prevent treat human diseases. (-)-alpha-Bisabolol is an unsaturated monocyclic sesquiterpene alcohol found as the major constituent many essential oils, like German chamomile (Chamomilla recutita (L.) Rauschert), a plant reported reduce perception acute pain for centuries their medicinal properties. Recently, our group demonstrated...
Context: The essential oil (EO) from Thymus capitatus Hoff. et Link. (Lamiaceae) has been traditionally used for its medicinal properties, such as anti-inflammatory, analgesic, antioxidant and antimicrobial properties.Objective: Characterize the constituents T. EO further evaluate antinociceptive activity by in vivo vitro procedures.Materials methods: Gas chromatography–mass spectrometry was to identify quantify of EO. evaluated glutamate-induced nociception model male Swiss mice (25 g), at...
Alpha-terpineol is monoterpene alcohol with anti-tumor activity against different tumor cell lines (lung, breast, leukemias and colorectal) through blockage of NF-kB expression, which play an important role in cells growth.Evaluate the antitumor alpha-terpineol murine Sarcoma 180 line.For tests, cytotoxic genotoxic assays were used, including Trypan blue, cytokinesis- blocked micronucleus assay, comet agarose gel DNA fragmentation, flow cytometry viability using fluorescence. Ascitic fluid...
Currently, there is an increasing demand for advanced materials that can address the needs of tissue engineering and have potential use in treatments targeting tumor cells, such as black bioactive photothermal therapy. Thus, 3D fibrous scaffolds 45S5 glass were produced using air-heated solution blow spinning (A-HSBS) technique, with polyvinylpyrrolidone (PVP) serving a aid oxygen vacancy-inducing agent. Glass powder same composition was synthesized via sol-gel route comparison. The samples...
Aniba rosaeodora is an aromatic plant which has been used in Brazil folk medicine due to its sedative effect. Therefore, the purpose of present study was evaluate effect linalool-rich rosewood oil mice. In addition we sought investigate effects on isolated nerve using single sucrose-gap technique.Sedative determined by measuring potentiation pentobarbital-induced sleeping time. The compound action potential amplitude evaluated as a way detect changes excitability nerve.The results showed...
In this study, we demonstrated the potential associative effect of combining conventional amphotericin B (Amph B) with gallic acid (GA) and ellagic (EA) in topical formulations for treatment cutaneous leishmaniasis BALB/c mice. Preliminary stability tests vitro drug release studies Amph B, GA, plus EA, EA were carried out, as well assessment vivo mice infected Leishmania major After 40 days infection, animals divided into 6 groups treated twice a day 21 gel containing or negative-control...
Abstract (–)‐Carvone is an antinociceptive monoterpene found as the main active constituent of essential oils obtained from plants genus Mentha . Here, we have investigated pharmacology this in dorsal root ganglia (DRG) neurons and TRPV1‐expressing HEK293 cells. (–)‐carvone at pharmacological concentrations did not reveal significant cytotoxicity to cells used study, by neutral red propidium iodide flow cytometry assays. In calcium imaging experiments 1 mM increased cytosolic levels DRG...
Colorectal cancer (CRC) is an important public health problem estimated as the third most commonly diagnosed worldwide. Naphthoquinones are compounds present in different families of plants and interesting for medicinal chemistry due to their activities potent inhibitors human growth. In this way, our study aimed evaluate cytotoxicity selectiveness four 2,3-triazole-1,4-naphthoquinone derivatives (N1-N4) towards CRC cell line HT-29 normal cells. MTT assay showed that N1, N2, N3 N4 elicited...
Cellulase refers to a group of enzymes like endoglucanases (CMCase), exoglucanases and β-glucosidase that have great industrial importance for the production second-generation ethanol, e.g. The present study aimed evaluate CMCase activities fungal strain Penicillium sp. FSDE15 using different agroindustrial wastes (wheat bran, sugarcane bagasse straw) as carbon sources basal medium during Submerged Fermentation (SFm). When presented wheat highest yields were 1.03 U/mL (96 h) 1.68 (168 h),...
The essential oil from Conyza bonariensis (Asteraceae) aerial parts (CBEO) was extracted by hydrodistillation in a Clevenger-type apparatus and characterized gas chromatography–mass spectrometry. antitumor potential evaluated against human tumor cell lines (melanoma, cervical, colorectal, leukemias), as well non-tumor keratinocyte using the MTT assay. effect of CBEO on production Reactive Oxygen Species (ROS) DCFH-DA assay, protection assay antioxidant N-acetyl-L-cysteine (NAC) also...
Abstract Objectives The aim of this study was to investigate the cytotoxic effect new 1,4-naphthoquinone- 1,2,3-triazoles, named C2 C8 triazole derivatives, towards human cancer cell lines. Methods on viability assessed by MTT and propidium iodide assays. C3 in K562 HL-60 cells were analyzed flow cytometry, DNA fragmentation reactive oxygen species (ROS) production. Western blot q-PCR procedures also performed. Key findings inhibited both growth a concentration-dependent manner. presented...
Gingerol - [6]-gingerol ((S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; [6]-G) is a phenolic compound with several pharmacological properties. Herein, the aim of study was to evaluate toxicogenic effects [6]-G on Artemia salina nauplii, Allium cepa, HL-60 cell line and Sarcoma 180 (S-180) ascitic fluid cells.For toxic genotoxic analysis, it used concentrations 5, 10, 20 40 μg mL-1. For cytotoxic evaluation using MTT test (3- [4,5-dimethyl-thiazol-2-yl] -2,5-diphenyl tetrazolium...