A5017853936- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Plant Pathogens and Fungal Diseases
- Essential Oils and Antimicrobial Activity
- Nail Diseases and Treatments
- Probiotics and Fermented Foods
- Mycotoxins in Agriculture and Food
- Phytochemistry Medicinal Plant Applications
- Psidium guajava Extracts and Applications
- Oral health in cancer treatment
- Infectious Diseases and Mycology
- Sesquiterpenes and Asteraceae Studies
- Pesticide Residue Analysis and Safety
- Wheat and Barley Genetics and Pathology
- Advancements in Transdermal Drug Delivery
- Infections and bacterial resistance
- Enterobacteriaceae and Cronobacter Research
- Reproductive tract infections research
- Microbial Natural Products and Biosynthesis
- Pneumocystis jirovecii pneumonia detection and treatment
- Oral microbiology and periodontitis research
- Yeasts and Rust Fungi Studies
- Surfactants and Colloidal Systems
- Radiation Effects and Dosimetry
- Ocular Infections and Treatments
Universidade Federal da Paraíba
2021-2025
Universidade Federal do Rio Grande do Norte
2013-2024
Centro Universitário do Rio Grande do Norte
2019
Sporotrichosis is a worldwide subcutaneous mycosis caused by Sporothrix spp. In the past, this infection was associated with armadillo hunting, horticulturists, miners, and gardeners, being considered an implantation acquired plant debris injury. Nevertheless, since late nineties, it has been zoonotic disease in Brazil. Here we report case series of 121 patients cat-transmitted sporotrichosis seen Northeast Brazil.Patient's demographic, clinical data, length treatment were recorded....
Candida albicans is associated with serious infections in immunocompromised patients. Terpenes are natural-product derivatives, widely studied as antifungal alternatives. In a previous study reported by our group, the activity of α-pinene against C. was verified; presented an MIC between 128-512 µg/mL. this study, we evaluate time-kill, mechanism action using silico and vitro tests, anti-biofilm albicans, toxicity human cells (HaCaT). Results from molecular-docking simulation demonstrated...
Several studies have been developed regarding human health risks associated with the recreational use of beaches contaminated domestic sewage. These wastes contain various micro-organisms, including Candida tropicalis. In this context, objective study was to characterize C. tropicalis isolates from sandy beach Ponta Negra, Natal, Rio Grande do Norte, Brazil, expression in vitro virulence factors, adaptation osmotic stress and susceptibility antifungal drugs. We analyzed 62 environmental...
Candida albicans is a diploid yeast that in some circumstances may cause oral or oropharyngeal infections. This investigation aimed to study the prevalence of spp. and analyze ABC genotypes 76 clinical isolates C. obtained from cavity kidney transplant patients two distinct geographic regions Brazil. We typed 48 strains with genotyping Microsatelitte using primer M13 tested three virulence factors vitro: phospholipase activity, morphogenesis ability evade polymorphonuclear neutrophils...
Background A relevant case of pulmonary sporotrichosis due to Sporothrix brasiliensis is reported in a 50-year-old immunocompetent woman who had no history skin trauma, but was close contact with several stray cats at her nap time. The patient hospitalized after 7 months illness. survey conducted for tuberculosis, an endemic disease Brazil. She presented multiple central nodules images, cavitation. Methodology/Principal findings bronchoalveolar lavage cultured and sp. growth obtained. Then,...
Candida albicans is a diploid yeast that in some circumstances may cause oral or oropharyngeal infections. Yeasts virulence factors contribute for both the maintenance of colonizing strains addition to damage and tissue invasion, thus establishment infection occurs. The limited arsenal antifungal drugs treatment candidiasis turn investigation natural products mandatory discovery new targets drug development. Therefore, tropical countries emerge as important providers with potential...
This study evaluated the influence of extract Eugenia uniflora in adhesion to human buccal epithelial cells (HBEC) biofilm formation and cell surface hydrophobicity (CSH) Candida spp. isolated from oral cavity kidney transplant patients. To evaluate virulence attributes vitro, nine yeasts were grown presence absence 1000 μg/mL extract. Adhesion was quantified using number adhered 150 HBEC determined by optical microscope. Biofilm two methodologies: XTT...
Trichosporon spp. are emerging pathogens that may cause high mortality rates, specifically among immunocompromised individuals. The objectives of this study were to perform a phylogenetic analysis clinical isolates. We also evaluated the expression different virulence factors in vitro. In addition, isolates grown presence cell-wall and membrane stressors. antifungal susceptibility profiling was determined. most prevalent strains belonged recently described species T. austroamericanum, with...
Resumo Esta pesquisa tem como objetivos identificar e reunir na literatura científica estudos que avaliam o uso de óleos essenciais em modelos infecção ungueal ou ensaios clínicos. Foram realizadas buscas cinco bases dados: PubMed, Scopus, Scielo, Embase Google Acadêmico, sendo recuperadas 184 referências após a retirada duplicatas, resultando seis estudos, foram selecionados incluídos síntese análise qualitativa final. Os melaleuca, cravo, orégano tomilho mostraram-se possíveis candidatos...
Cryptococcosis is an infectious disease of worldwide distribution, caused by encapsulated yeasts belonging to the phylum Basidiomycota. The genus Cryptococcus includes several species distributed around world. C. gattii/neoformans complex largely responsible for most cases cryptococcosis. However, clinical series have been published infections Papiliotrema (Cryptococcus) laurentii and Naganishia albida (Cryptococcus albidus), among other related genera. Here, we examined pathogenic potential...
In the present study, occurrence of fungi and aflatoxins (AFs) in peanut cashew nut samples was investigated. Mycological analysis revealed presence 58.8% samples, assessment AFs by chromatographic methods that 52.9% were contaminated AFs. AFB1 principal component all AF-contaminated with a mean level 14.0, 1.08 µg/kg nut, respectively. Eleven (32.4%) exceeded total AF maximum (4 μg/kg) 8 (23.5%) (2 established European Commission. Our findings suggest incidence emphasizes need for regular...
Under certain circumstances, Candida albicans may switch from colonizing to infective yeast. Morphogenesis in C. and resistance oxidative stress is an essential step for establishment of infection. Due the reduced drug available emergence resistant strains, it mandatory search new therapeutic sources. This study aimed investigate which proteins are differentially expressed during morphogenesis, after cells growth presence ethyl acetate fraction Eugenia uniflora. We also evaluated interaction...
The aim of this study was evaluate the in vitro antifungal activity crude extracts from Eugenia uniflora, Libidibia ferrea and Psidium guajava. were obtained by turbo-extraction using water (AQ) or acetone-water (AC-W) (7:3, v/v) as solvents lyophilized to obtain (CE). CE characterized UV-Vis, TLC HPLC. CEs investigated against clinical isolates Candida spp. Minimum Inhibitory Concentration (MIC), MIC50 MIC90 determinated. analysis showed that all presented polyphenols (flavonoids tannins)....