A5060413213- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Plant Pathogens and Fungal Diseases
- Nail Diseases and Treatments
- Essential Oils and Antimicrobial Activity
- Infectious Diseases and Mycology
- Pneumocystis jirovecii pneumonia detection and treatment
- Reproductive tract infections research
- Infections and bacterial resistance
- Phytochemistry Medicinal Plant Applications
- Yeasts and Rust Fungi Studies
- Antimicrobial Peptides and Activities
- Advanced Drug Delivery Systems
- Probiotics and Fermented Foods
- Biochemical and Structural Characterization
- Advancements in Transdermal Drug Delivery
- Bee Products Chemical Analysis
- Mycotoxins in Agriculture and Food
- HIV/AIDS oral health manifestations
- Psidium guajava Extracts and Applications
- Lipid Membrane Structure and Behavior
- Oral health in cancer treatment
- Antimicrobial agents and applications
- Food Safety and Hygiene
- Radiation Effects and Dosimetry
Universidade Federal do Rio Grande do Norte
2016-2025
Westerdijk Fungal Biodiversity Institute
2024
Centro Universitário do Rio Grande do Norte
2019
Universidade Federal de São Paulo
2008-2012
University of Aberdeen
2007
Universidade Federal de Pernambuco
2002-2004
The reevaluation of the genus Trichosporon has led to replacement old taxon beigelii by six new species. Sequencing ribosomal DNA (rDNA) intergenic spacer 1 (IGS1) is currently mandatory for accurate identification, but it not usually performed in routine laboratories. Here we describe species distribution and prevalence asahii genotypes based on rDNA IGS1 sequencing as well antifungal susceptibility profiles 22 isolates recovered from blood cultures. clinical were identified follows: 15 T....
To provide species distribution and antifungal susceptibility profiles of 358 Trichosporon clinical isolates collected from 24 tertiary-care hospitals.Species identification was performed by sequencing the IGS1 region rDNA. Antifungal testing for amphotericin B, fluconazole, voriconazole posaconazole followed Clinical Laboratory Standards Institute reference method. Tentative epidemiologic cutoff values (97.5% ECVs) antifungals asahii were also calculated.Isolates cultured mostly urine...
Candidemia has been considered a persistent public health problem with great impact on hospital costs and high mortality. We aimed to evaluate the epidemiology prognostic factors of candidemia in tertiary Northeast Brazil from January 2011 December 2016. Demographic clinical data patients were retrospectively obtained medical records antifungal susceptibility profiling was performed using broth microdilution method. A total 68 episodes evaluated. found an average incidence 2.23 /1000...
Sporotrichosis is a worldwide subcutaneous mycosis caused by Sporothrix spp. In the past, this infection was associated with armadillo hunting, horticulturists, miners, and gardeners, being considered an implantation acquired plant debris injury. Nevertheless, since late nineties, it has been zoonotic disease in Brazil. Here we report case series of 121 patients cat-transmitted sporotrichosis seen Northeast Brazil.Patient's demographic, clinical data, length treatment were recorded....
The aim of this work was to investigate the antimicrobial activity nanostructured emulsions based on copaiba (Copaifera langsdorffii) resin-oil, essential oil, and bullfrog (Rana catesbeiana Shaw) oil against fungi bacteria related skin diseases. Firstly, extracted from resin-oil these oils, along with were characterized by gas chromatography combined mass spectrometry (GC-MS). Secondly, emulsion systems produced characterized. susceptibility assay performed, followed Minimum Inhibitory...
Several studies have been developed regarding human health risks associated with the recreational use of beaches contaminated domestic sewage. These wastes contain various micro-organisms, including Candida tropicalis. In this context, objective study was to characterize C. tropicalis isolates from sandy beach Ponta Negra, Natal, Rio Grande do Norte, Brazil, expression in vitro virulence factors, adaptation osmotic stress and susceptibility antifungal drugs. We analyzed 62 environmental...
Candida albicans is a diploid yeast that in some circumstances may cause oral or oropharyngeal infections. This investigation aimed to study the prevalence of spp. and analyze ABC genotypes 76 clinical isolates C. obtained from cavity kidney transplant patients two distinct geographic regions Brazil. We typed 48 strains with genotyping Microsatelitte using primer M13 tested three virulence factors vitro: phospholipase activity, morphogenesis ability evade polymorphonuclear neutrophils...
Background A relevant case of pulmonary sporotrichosis due to Sporothrix brasiliensis is reported in a 50-year-old immunocompetent woman who had no history skin trauma, but was close contact with several stray cats at her nap time. The patient hospitalized after 7 months illness. survey conducted for tuberculosis, an endemic disease Brazil. She presented multiple central nodules images, cavitation. Methodology/Principal findings bronchoalveolar lavage cultured and sp. growth obtained. Then,...
Abstract Background Trichosporon fungaemia (TF) episodes have increased in recent years and mortality rates remain high despite the advances management of sepsis. New concepts about its clinical course, treatment microbiology need to be investigated for better this infection. Objectives To describe aetiology, natural history, prognostic factors TF. Methods TF documented between 2005 2018 23 South American centres were retrospectively by using a standard form. Molecular identification,...
is emerging as one of the most common
Candida albicans is a diploid yeast that in some circumstances may cause oral or oropharyngeal infections. Yeasts virulence factors contribute for both the maintenance of colonizing strains addition to damage and tissue invasion, thus establishment infection occurs. The limited arsenal antifungal drugs treatment candidiasis turn investigation natural products mandatory discovery new targets drug development. Therefore, tropical countries emerge as important providers with potential...
This study evaluated the influence of extract Eugenia uniflora in adhesion to human buccal epithelial cells (HBEC) biofilm formation and cell surface hydrophobicity (CSH) Candida spp. isolated from oral cavity kidney transplant patients. To evaluate virulence attributes vitro, nine yeasts were grown presence absence 1000 μg/mL extract. Adhesion was quantified using number adhered 150 HBEC determined by optical microscope. Biofilm two methodologies: XTT...
The limited arsenal of antifungal drugs have prompted the search for novel molecules with biological activity. This study aimed to characterize mechanism action Eugenia uniflora extract and its synergistic activity commercially available on following Candida species: C. albicans, tropicalis, glabrata, parapsilosis dubliniensis. In silico analysis was performed predict major compounds present in extract. Minimal inhibitory concentrations (MICs) were determined presence exogenous ergosterol...
Trichosporon spp. are emerging pathogens that may cause high mortality rates, specifically among immunocompromised individuals. The objectives of this study were to perform a phylogenetic analysis clinical isolates. We also evaluated the expression different virulence factors in vitro. In addition, isolates grown presence cell-wall and membrane stressors. antifungal susceptibility profiling was determined. most prevalent strains belonged recently described species T. austroamericanum, with...
To cope with oxidative stress, Candida albicans possesses several enzymes involved in a number of biological processes, including superoxide dismutases (Sods) and glutaredoxins (Grxs). The resistance C. to reactive oxygen species is thought act as virulence factor. Genes such SOD1 GRX2, which encode for Sod Grx, respectively, are widely recognised be important pathogenesis. We generated double mutant, Δgrx2/sod1, both genes. This strain very defective hyphae formation susceptible killing by...