A5052797469- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- Medicinal Plants and Neuroprotection
- Phytochemistry Medicinal Plant Applications
- Pharmacological Effects of Natural Compounds
- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Chemical synthesis and alkaloids
- Alkaloids: synthesis and pharmacology
- Medicinal Plant Extracts Effects
- Natural product bioactivities and synthesis
- Cholinesterase and Neurodegenerative Diseases
- Natural Antidiabetic Agents Studies
- Ethnobotanical and Medicinal Plants Studies
- Neurotransmitter Receptor Influence on Behavior
- Olfactory and Sensory Function Studies
- Traditional and Medicinal Uses of Annonaceae
- Bioactive Compounds and Antitumor Agents
- Plant-based Medicinal Research
- Plant Toxicity and Pharmacological Properties
- Botanical Research and Chemistry
- Berberine and alkaloids research
- Pharmacology and Obesity Treatment
- Morinda citrifolia extract uses
- Epilepsy research and treatment
Universidade Federal da Paraíba
2015-2024
State University of Norte Fluminense
2019
Universidade Federal de Pernambuco
1990-2013
Universidade Federal do Piauí
2002-2012
Universidade Federal do Vale do São Francisco
2008-2011
Universidade de Brasília
2010
Universidad de Santiago de Chile
2009
Universidade Federal de Sergipe
2009
University of Tennessee at Knoxville
2006
Universidade Federal do Pará
2003
The objective of the present study was to evaluate antinociceptive effects phytol using chemical and thermal models nociception in mice assess its antioxidant vitro. Phytol administered intraperitoneally (i.p.) at doses 25, 50, 100, 200 mg/kg. In acetic acid-induced writhing test, significantly reduced number contortions compared control group (P < 0.001). formalin amount time spent paw licking both phases (the neurogenic inflammatory phases), this effect being more pronounced second phase...
Linalool oxide is a monoterpene that found in some species of aromatic plants. The effects the inhalation linalool (0.65%, 1.25%, 2.5% and 5.0% w/w) elevated plus-maze light/dark box tests as animal models anxiety were investigated adult male mice compared with reference anxiolytic diazepam (0.5 2.0 mg/kg), administered intraperitoneally. Additionally, inhaled rotarod test. significantly increased number visits to open arms amount time spent there well total entries. In test, led an increase...
The traditional use of essential oils in aromatherapy has offered numerous health benefits. However, few scientific studies have been conducted with these to confirm their therapeutic efficacy. (+)-Limonene is a chemical constituent various bioactive oils. present study reports on the anxiolytic-like effects (+)-limonene an elevated maze model anxiety mice. At concentrations 0.5% and 1.0%, (+)-limonene, administered mice by inhalation, significantly modified all parameters evaluated plus...
(−)-Carvone is a monoterpene ketone that the main active component of Mentha plant species like spicata. This study aimed to investigate antinociceptive activity (−)-carvone using different experimental models pain and whether such effects might be involved in nervous excitability elicited by others monoterpenes. In acetic acid-induced writhing test, we observed (−)-carvone-treated mice exhibited significant decrease number writhes when 100 200 mg/kg was administered. It also demonstrated...
The antioxidant activity of four species the Malvaceae family (Sidastrum micranthum (A. St.-Hil.) Fryxell, Wissadula periplocifolia (L.) C. Presl, Sida rhombifolia E. H. L and Herissantia crispa L. (Brizicky)) were studied using total phenolic content, DPPH radical scavenging Trolox equivalent capacity (TEAC) assays. crude extract, phases two isolated flavonoids, kaempferol 3,7-di-O-α-l-rhamnopyranoside (lespedin) 3-O-β-d-(6''-E-p-coumaroil) glucopyranoside (tiliroside) was determined....
The orange essential oil (OEO) and its components obtained from Citrus aurantium L. (Rutaceae) has been attracting interest due to sedative relaxing actions. In the present study, rats previously exposed OEO at concentrations of 1.0%; 2.5% 5.0%, w/w, by inhalation during 7 minutes in acrylic boxes were evaluated two anxiety models: elevated plus maze (EPM) open-field. concentration increased both time animals open arms EPM active social interaction open-field being longer than that diazepam...
Nerolidol, an acyclic sesquiterpene found as a major constituent of several essential oils, has pharmacological activities, but its action in pain processes never been studied. The purpose our research was to evaluate the antinociceptive and anti-inflammatory activities nerolidol, well possible mechanisms action, experimental mouse models pain. Antinociceptive activity evaluated using acetic acid-induced writhing test, formalin hot-plate test. nerolidol-treated group showed lesser abdominal...
The bone marrow aspiration procedure is used in hematological diseases and consists of a painful, invasive causing anxiety‐associated symptoms. present study assessed the effect Citrus aurantium L. essential oil on treatment anxiety, moment that precedes collection medullary material patients with chronic myeloid leukemia (CML). Volunteers from both sexes were divided into groups receiving either C. through inhalation , diazepam (10 mg), or placebo. evaluation was performed psychometric...
Abstract Many terpenes are used therapeutically, and as flavor fragrance materials. ( R )‐(−)‐Carvone, the main constituent of spearmint oil, S )‐(+)‐carvone, found major component caraway dill seed oils, have several applications in cosmetic, food, pharmaceutical preparations. In this study, effect enantiomers carvone on central nervous system (CNS) was evaluated mice. The LD 50 value 484.2 mg/kg (358.9–653.2) for 426.6 (389.0–478.6) )‐(−)‐carvone. Both caused depressant effects, such...
α-Terpineol, a monoterpenoid alcohol, was investigated for its anticonvulsant activity. This compound increased the latency to convulsions induced by pentylenetetrazole at doses of 100 and 200 mg/kg decreased incidence hindlimb extension produced MES in dose-related manner 400 mg/kg.
Context: α-Terpineol (TPN) is a monoterpenoid alcohol present in the essential oils of several species Eucalyptus genus (Myrtaceae).
The anticonvulsant activity of the racemate and enantiomers linalool have been evaluated. Pretreatment mice with (S)-(+)-, (R)-(-)- rac-linalool increased latency convulsions significantly in PTZ model. Only had an effect at dose 200 mg/kg. their racemic mixture were effective inhibiting convulsant 300 linalools presented pharmacological close to that diazepam. In PIC seizure model, (R)-(-)-linalool mg/kg, but was more potent than (R)-(-)-linalool; (S)-(+)-linalool no this dose. On other...
ABSTRACT Inflammation is characterized by vasodilatation, increase of blood flow and vascular permeability, migration leucocytes to the inflammatory site, production cytokines. The aim this study was evaluate anti‐inflammatory antinociceptive effects (−)‐myrtenol, a plant‐derived monoterpene alcohol, in mice its possible mechanisms. Myrtenol used classical models inflammation (paw oedema induced different agents, carrageenan‐induced peritonitis, myeloperoxidase levels cytokine measurement)...