A5075669921- Pain Mechanisms and Treatments
- Essential Oils and Antimicrobial Activity
- Neuropeptides and Animal Physiology
- Phytochemistry and Bioactive Compounds
- Tendon Structure and Treatment
- Pharmacological Effects of Natural Compounds
- Seaweed-derived Bioactive Compounds
- Lipid Membrane Structure and Behavior
- Cancer, Stress, Anesthesia, and Immune Response
- Veterinary Oncology Research
- Microbial Metabolites in Food Biotechnology
- Natural product bioactivities and synthesis
- Nerve injury and regeneration
- Inflammatory mediators and NSAID effects
- Microbial infections and disease research
- Connexins and lens biology
- Congenital gastrointestinal and neural anomalies
- Marine Sponges and Natural Products
- Milk Quality and Mastitis in Dairy Cows
- Vascular Tumors and Angiosarcomas
- Ion channel regulation and function
- Biological Activity of Diterpenoids and Biflavonoids
- Sesquiterpenes and Asteraceae Studies
- Periodontal Regeneration and Treatments
- Vascular Malformations and Hemangiomas
Universidade Estadual de Campinas (UNICAMP)
2020-2024
Universidade de São Paulo
2024
Universidade Federal Rural do Rio de Janeiro
2017-2022
University of California, San Diego
2022
Hospital de Clínicas da Unicamp
2021
Universidade Federal do Piauí
2012-2017
Abstract Studies have shown that diterpenes anti‐inflammatory and redox‐protective pharmacological activities. The present study aimed to investigate the properties of phytol, a diterpene alcohol, in mouse model acute inflammation, phytol effect on leukocyte recruitment, cytokines levels, oxidative stress. activities were assessed by measuring paw edema induced different inflammatory agents (e.g., λ‐carrageenan, compound 48/80, histamine, serotonin, bradykinin, prostaglandin E 2 [ PGE ]),...
The aim of this study was to investigate the antinociceptive and anti-inflammatory activities epiisopiloturine (1), an imidazole alkaloid found in leaves Pilocarpus microphyllus. activity 1 evaluated using several agents that induce paw edema peritonitis Swiss mice. Paw tissue peritoneal fluid samples were obtained determine myeloperoxidase (MPO) or tumor necrosis factor (TNF)-α interleukin (IL)-1β levels. by acetic acid-induced writhing, hot plate test, pain induction formalin. Compared...
ABSTRACT Inflammation is characterized by vasodilatation, increase of blood flow and vascular permeability, migration leucocytes to the inflammatory site, production cytokines. The aim this study was evaluate anti‐inflammatory antinociceptive effects (−)‐myrtenol, a plant‐derived monoterpene alcohol, in mice its possible mechanisms. Myrtenol used classical models inflammation (paw oedema induced different agents, carrageenan‐induced peritonitis, myeloperoxidase levels cytokine measurement)...
ABSTRACT Preclinical Research Long‐term use nonsteroidal anti‐inflammatory drug is associated with gastrointestinal (GI) lesion formation. The aim of this study was to investigate the protective activity cashew gum (CG), a complex heteropolysaccharide extracted from Anacardium occidentale on naproxen (NAP)‐induced GI damage. Male Wistar rats were pretreated vehicle or CG (1, 3, 10, and 30 mg/kg, p.o.) twice daily for 2 days; after 1 h, NAP (80 administered. euthanized 2nd day treatment, 4 h...
Red seaweeds synthesize a great variety of sulfated galactans. Sulfated polysaccharides (PLSs) from seaweed are comprised substances with pharmaceutical and biomedical potential. The aim the present study was to evaluate protective effect PLS fraction extracted Gracilaria birdiae in rats naproxen-induced gastrointestinal damage. Male Wistar were pretreated 0.5% carboxymethylcellulose (control group—vehicle) or (10, 30, 90 mg/kg, p.o.) twice daily (at 09:00 21:00) for 2 days. After 1 h,...
Our objective was to investigate the protective effect of Lawesson's reagent, an H2S donor, against alendronate (ALD)-induced gastric damage in rats. Rats were pretreated with saline or reagent (3, 9, 27 µmol/kg, po) once daily for 4 days. After 30 min, induced by ALD (30 mg/kg) administration gavage. On last day treatment, animals killed h after administration. Gastric lesions measured using a computer planimetry program, and corpus pieces assayed malondialdehyde (MDA), glutathione (GSH),...
The local anesthetic Butamben was encapsulated in NLC and characterized.<italic>In vitro</italic>tests showed decreased cytotoxicity and<italic>in vivo</italic>it improved the anesthesia inflamed tissue.
Background: Pannexin1 (Panx1) is a membrane channel expressed in different cells of the nervous system and involved several pathological conditions, including pain inflammation. At central system, role Panx1 already well-established. However, periphery, there lack information regarding participation neuronal sensitization. The dorsal root ganglion (DRG) critical structure for processing modulation. For this reason, understanding molecular mechanism DRG associated with hypersensitivity has...
Background: Congenital cardiac diseases are a common cause of death in puppies. Tricuspid valve dysplasia is characterized by thickening and displacement the leaflets tricuspid valve, agenesis valves, incomplete separation components. Papillary muscles may fuse display shortened or absent chordae tendineae that contribute to regurgitation. Diagnostic features include cardiomegaly with massive right atrium enlargement on thoracic radiography insufficiency an ultrasound. We aimed describe...
Abstract Platelet-rich plasma (PRP) is a biological blood-derived therapeutic that releases several proteins in injured tissue, regulating the inflammatory process and triggering tissue anabolism. Outside of central nervous system (CNS), these platelets represent major source brain-derived neurotrophic factor (BDNF). The associated anti-inflammatory, antiapoptotic, antioxidant properties this neurotrophin could have potential applicability applied pathophysiology osteoarthritis (OA). In...
A Síndrome de Burnout é bastante prevalente entre profissionais da saúde, principalmente em função desgastante jornada trabalho, apresentando impactos negativos diversos âmbitos como o pessoal e institucional. O objetivo do artigo analisar as causas consequências nos área saúde. fim apurar campo pesquisas sobre esse tema, realizou-se uma revisão narrativa literatura com uso das bases dados Scielo, PubMed Lilacs dos descritores “Síndrome Burnout”, “Burnout”, “Esgotamento Psicológico”...
Background: Hemangiosarcoma is a malignant mesenchymal neoplasm of endothelial cells that mainly affects dogs and less common in horses, cattle, goats, pigs, sheep. In ruminants, however, few cases hemangiosarcoma have been reported. Although this may primarily occur any tissue, it most often originates the spleen, liver, heart, skin. This study reports clinical pathological findings bovine hemangiosarcoma.Case: A 10-year-old lactating Girolando cow from municipality Vassouras/RJ was...
The diagnosis of unstable non-acid milk (UNAM) in Brazil is overlooked due to the lack information about this problem available dairy farmers, mainly North region country. This report describes occurrence UNAM three farms family farmers northern Tocantins state, Brazil, who use animal feed based on Urochloa brizantha without mineral supplementation. animals had been subjected a poor feeding practice, with low quantity and quality, dry period inappropriate nutritional management. Fourteen...
Background: Anal atresia is a congenital malformation, which often affects calves, and related to the imperforation of membrane that separates endoderm posterior intestine from ectodermal anal membrane. It commonly associated with other malformations skeletal anomalies. The clinical signs generally appear in first days animal's life, due retention feces. diagnosis based on observation, anamnesis physical examination animal. only viable treatment surgical. This paper aims report 6 cases...
Our study aimed to report a case of prosencephalic hypoplasia, condition in which the rostral end ofthe brain hemispheres is absent, crossbred calf. Grossly, prosenchephalic (telencephalon anddiencephalon) region was poorly developed and reduced size; wereabsent, convolutions were delimited. Etiology this domestic animals isunknown. Hereditary factors toxic infectious agents may lead congenital defects
Abstract Inflammation is a vital process for the injured tissue restoration and one of its hallmarks inflammatory hyperalgesia. The cyclooxygenase (COX) pathway strongly related to painful process. Usually, COX-1 isoform described as homeostatic, while COX-2 characterized inducible in conditions. Although it well known that neutrophil cells are first arrive at inflamed site major source still unknown specific role neutrophil-derived Cox-2 pain is. Thus, present study, we demonstrate time...